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Go-no-go task performance improvement after anodal transcranial DC stimulation of the left dorsolateral prefrontal cortex in major depression.
J Affect Disord 2007; 101(1-3):91-8JA

Abstract

BACKGROUND

We recently showed that repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) can affect the performance in an affective go-no-go (AGN) task. We aimed to extend this previous investigation testing whether one session of anodal transcranial direct current stimulation (tDCS) of the left DLPFC, as compared with anodal occipital and sham tDCS, affects this AGN task performance.

METHODS

Twenty-six patients with major depression were randomized to receive anodal tDCS of the left DLPFC, occipital cortex or sham tDCS (the cathode electrode was placed over the frontopolar area for the three conditions). An AGN task was performed immediately before and after treatment. Performance changes (pre and post-treatment) were compared across groups of treatment and correlated with Hamilton Depression Rating Scale (HDRS) score changes.

RESULTS

The results show that anodal stimulation of the left DLPFC was the only condition that induced a significant improvement in task performance as shown by the increase in the number of correct responses. In addition, this effect was specific for figures with positive emotional content. This performance enhancement was not correlated with mood changes after 10 days of tDCS treatment.

LIMITATIONS

Although the effects of tDCS are less focal than rTMS, it can induce a longer and stronger modulation of cortical excitability.

CONCLUSIONS

Our findings suggest that left DLPFC activity is associated with positive emotional processing, confirming and extending results of previous studies that associated right DLPFC and orbito-frontal cortex activity with emotional processing. Furthermore the effects of tDCS on mood and cognition seem to be independent in major depression. These lines of evidence together shed light on the neural circuitry involved with emotional processing in major depression.

Authors+Show Affiliations

Department of Experimental Psychology, University of Sao Paulo, Sao Paulo, Brazil. Boggio@usp.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17166593

Citation

Boggio, Paulo S., et al. "Go-no-go Task Performance Improvement After Anodal Transcranial DC Stimulation of the Left Dorsolateral Prefrontal Cortex in Major Depression." Journal of Affective Disorders, vol. 101, no. 1-3, 2007, pp. 91-8.
Boggio PS, Bermpohl F, Vergara AO, et al. Go-no-go task performance improvement after anodal transcranial DC stimulation of the left dorsolateral prefrontal cortex in major depression. J Affect Disord. 2007;101(1-3):91-8.
Boggio, P. S., Bermpohl, F., Vergara, A. O., Muniz, A. L., Nahas, F. H., Leme, P. B., ... Fregni, F. (2007). Go-no-go task performance improvement after anodal transcranial DC stimulation of the left dorsolateral prefrontal cortex in major depression. Journal of Affective Disorders, 101(1-3), pp. 91-8.
Boggio PS, et al. Go-no-go Task Performance Improvement After Anodal Transcranial DC Stimulation of the Left Dorsolateral Prefrontal Cortex in Major Depression. J Affect Disord. 2007;101(1-3):91-8. PubMed PMID: 17166593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Go-no-go task performance improvement after anodal transcranial DC stimulation of the left dorsolateral prefrontal cortex in major depression. AU - Boggio,Paulo S, AU - Bermpohl,Felix, AU - Vergara,Adriana O, AU - Muniz,Ana L C R, AU - Nahas,Fernanda H, AU - Leme,Priscila B, AU - Rigonatti,Sergio P, AU - Fregni,Felipe, Y1 - 2006/12/12/ PY - 2006/08/02/received PY - 2006/10/17/revised PY - 2006/10/31/accepted PY - 2006/12/15/pubmed PY - 2007/8/19/medline PY - 2006/12/15/entrez SP - 91 EP - 8 JF - Journal of affective disorders JO - J Affect Disord VL - 101 IS - 1-3 N2 - BACKGROUND: We recently showed that repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) can affect the performance in an affective go-no-go (AGN) task. We aimed to extend this previous investigation testing whether one session of anodal transcranial direct current stimulation (tDCS) of the left DLPFC, as compared with anodal occipital and sham tDCS, affects this AGN task performance. METHODS: Twenty-six patients with major depression were randomized to receive anodal tDCS of the left DLPFC, occipital cortex or sham tDCS (the cathode electrode was placed over the frontopolar area for the three conditions). An AGN task was performed immediately before and after treatment. Performance changes (pre and post-treatment) were compared across groups of treatment and correlated with Hamilton Depression Rating Scale (HDRS) score changes. RESULTS: The results show that anodal stimulation of the left DLPFC was the only condition that induced a significant improvement in task performance as shown by the increase in the number of correct responses. In addition, this effect was specific for figures with positive emotional content. This performance enhancement was not correlated with mood changes after 10 days of tDCS treatment. LIMITATIONS: Although the effects of tDCS are less focal than rTMS, it can induce a longer and stronger modulation of cortical excitability. CONCLUSIONS: Our findings suggest that left DLPFC activity is associated with positive emotional processing, confirming and extending results of previous studies that associated right DLPFC and orbito-frontal cortex activity with emotional processing. Furthermore the effects of tDCS on mood and cognition seem to be independent in major depression. These lines of evidence together shed light on the neural circuitry involved with emotional processing in major depression. SN - 0165-0327 UR - https://www.unboundmedicine.com/medline/citation/17166593/Go_no_go_task_performance_improvement_after_anodal_transcranial_DC_stimulation_of_the_left_dorsolateral_prefrontal_cortex_in_major_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(06)00466-6 DB - PRIME DP - Unbound Medicine ER -