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Effects of Helicobacter pylori infection on gut appetite peptide (leptin, ghrelin) expression in elderly inpatients.
J Gerontol A Biol Sci Med Sci. 2006 Nov; 61(11):1144-50.JG

Abstract

The aim of the study was to investigate the relationship between gastritis and leptin and ghrelin in elderly patients. Patients older than 75 years undergoing an endoscopy were included. We reported data on nutritional status and Helicobacter pylori infection diagnosis (serology, 13C-urea breath test, culture, histology, and polymerase chain reaction on gastric biopsies). Gastric messenger RNA expression of leptin and ghrelin were quantified by real-time polymerase chain reaction. Sixty-two patients were included (84.7 +/- 5.2 years). H. pylori infection was associated with decreased gastric expression of leptin (p = .021), ghrelin (p =.002), and plasma ghrelin levels (p = .018). Atrophy was associated with decreased gastric leptin (p = .007) and ghrelin (p = .02). H. pylori infection correlated negatively with patient energy intake (r = -0.36; p = .001) and body mass index (r = -0.34; p = .018). The negative association between ghrelin and H. pylori infection may be related to a higher prevalence of atrophy and raises the possibility that H. pylori may be contributing to undernutrition in some older people.

Authors+Show Affiliations

INSERM ERI 10, Laboratoire de Bactériologie, Université Victor Segalen Bordeaux 2, Bât 2B RDC Zone Nord, 33076 Bordeaux cedex, France. nathalie.salles@chu-bordeaux.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17167154

Citation

Salles, Nathalie, et al. "Effects of Helicobacter Pylori Infection On Gut Appetite Peptide (leptin, Ghrelin) Expression in Elderly Inpatients." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 61, no. 11, 2006, pp. 1144-50.
Salles N, Ménard A, Georges A, et al. Effects of Helicobacter pylori infection on gut appetite peptide (leptin, ghrelin) expression in elderly inpatients. J Gerontol A Biol Sci Med Sci. 2006;61(11):1144-50.
Salles, N., Ménard, A., Georges, A., Salzmann, M., de Ledinghen, V., de Mascarel, A., Emeriau, J. P., Lamouliatte, H., & Mégraud, F. (2006). Effects of Helicobacter pylori infection on gut appetite peptide (leptin, ghrelin) expression in elderly inpatients. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 61(11), 1144-50.
Salles N, et al. Effects of Helicobacter Pylori Infection On Gut Appetite Peptide (leptin, Ghrelin) Expression in Elderly Inpatients. J Gerontol A Biol Sci Med Sci. 2006;61(11):1144-50. PubMed PMID: 17167154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Helicobacter pylori infection on gut appetite peptide (leptin, ghrelin) expression in elderly inpatients. AU - Salles,Nathalie, AU - Ménard,Armelle, AU - Georges,Agnès, AU - Salzmann,Mélanie, AU - de Ledinghen,Victor, AU - de Mascarel,Antoine, AU - Emeriau,Jean-Paul, AU - Lamouliatte,Hervé, AU - Mégraud,Francis, PY - 2006/12/15/pubmed PY - 2007/3/6/medline PY - 2006/12/15/entrez SP - 1144 EP - 50 JF - The journals of gerontology. Series A, Biological sciences and medical sciences JO - J Gerontol A Biol Sci Med Sci VL - 61 IS - 11 N2 - The aim of the study was to investigate the relationship between gastritis and leptin and ghrelin in elderly patients. Patients older than 75 years undergoing an endoscopy were included. We reported data on nutritional status and Helicobacter pylori infection diagnosis (serology, 13C-urea breath test, culture, histology, and polymerase chain reaction on gastric biopsies). Gastric messenger RNA expression of leptin and ghrelin were quantified by real-time polymerase chain reaction. Sixty-two patients were included (84.7 +/- 5.2 years). H. pylori infection was associated with decreased gastric expression of leptin (p = .021), ghrelin (p =.002), and plasma ghrelin levels (p = .018). Atrophy was associated with decreased gastric leptin (p = .007) and ghrelin (p = .02). H. pylori infection correlated negatively with patient energy intake (r = -0.36; p = .001) and body mass index (r = -0.34; p = .018). The negative association between ghrelin and H. pylori infection may be related to a higher prevalence of atrophy and raises the possibility that H. pylori may be contributing to undernutrition in some older people. SN - 1079-5006 UR - https://www.unboundmedicine.com/medline/citation/17167154/Effects_of_Helicobacter_pylori_infection_on_gut_appetite_peptide__leptin_ghrelin__expression_in_elderly_inpatients_ L2 - https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/61.11.1144 DB - PRIME DP - Unbound Medicine ER -