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The effect of nitric oxide generators on ischemia reperfusion injury and histamine release in isolated perfused guinea-pig heart.
Agents Actions. 1991 May; 33(1-2):53-6.AA

Abstract

Experiments were carried out to provide evidence of the effect of L-arginine (L-Arg), its analogue NG-monomethyl-L-arginine (MeArg) and of some nitrovasodilators (sodium nitroprusside, NaNP; 3-morpholino-sydnonimine, SIN-1) which spontaneously release nitric oxide (NO) on ischemia-reperfusion injury, histamine release and mast cell degranulation, occurring after multiple ligature and release of the left anterior descending (LAD) coronary artery in isolated perfused guinea-pig hearts. The reopening of the LAD coronary artery leads to a release of histamine related to a decrease in microdensitometry of cardiac mast cells and to calcium overload. The perfusion of the heart with NO-donors significantly reduces either the release of histamine, the loss of mast cell metachromasia and the overload of calcium. These effects were potentiated by SOD. The results suggest that the endogenous formation of NO and molecules able to generate NO have a role in the prevention of post-ischemic tissue injury.

Authors+Show Affiliations

Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1716836

Citation

Masini, E, et al. "The Effect of Nitric Oxide Generators On Ischemia Reperfusion Injury and Histamine Release in Isolated Perfused Guinea-pig Heart." Agents and Actions, vol. 33, no. 1-2, 1991, pp. 53-6.
Masini E, Bianchi S, Mugnai L, et al. The effect of nitric oxide generators on ischemia reperfusion injury and histamine release in isolated perfused guinea-pig heart. Agents Actions. 1991;33(1-2):53-6.
Masini, E., Bianchi, S., Mugnai, L., Gambassi, F., Lupini, M., Pistelli, A., & Mannaioni, P. F. (1991). The effect of nitric oxide generators on ischemia reperfusion injury and histamine release in isolated perfused guinea-pig heart. Agents and Actions, 33(1-2), 53-6.
Masini E, et al. The Effect of Nitric Oxide Generators On Ischemia Reperfusion Injury and Histamine Release in Isolated Perfused Guinea-pig Heart. Agents Actions. 1991;33(1-2):53-6. PubMed PMID: 1716836.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of nitric oxide generators on ischemia reperfusion injury and histamine release in isolated perfused guinea-pig heart. AU - Masini,E, AU - Bianchi,S, AU - Mugnai,L, AU - Gambassi,F, AU - Lupini,M, AU - Pistelli,A, AU - Mannaioni,P F, PY - 1991/5/1/pubmed PY - 1991/5/1/medline PY - 1991/5/1/entrez SP - 53 EP - 6 JF - Agents and actions JO - Agents Actions VL - 33 IS - 1-2 N2 - Experiments were carried out to provide evidence of the effect of L-arginine (L-Arg), its analogue NG-monomethyl-L-arginine (MeArg) and of some nitrovasodilators (sodium nitroprusside, NaNP; 3-morpholino-sydnonimine, SIN-1) which spontaneously release nitric oxide (NO) on ischemia-reperfusion injury, histamine release and mast cell degranulation, occurring after multiple ligature and release of the left anterior descending (LAD) coronary artery in isolated perfused guinea-pig hearts. The reopening of the LAD coronary artery leads to a release of histamine related to a decrease in microdensitometry of cardiac mast cells and to calcium overload. The perfusion of the heart with NO-donors significantly reduces either the release of histamine, the loss of mast cell metachromasia and the overload of calcium. These effects were potentiated by SOD. The results suggest that the endogenous formation of NO and molecules able to generate NO have a role in the prevention of post-ischemic tissue injury. SN - 0065-4299 UR - https://www.unboundmedicine.com/medline/citation/1716836/The_effect_of_nitric_oxide_generators_on_ischemia_reperfusion_injury_and_histamine_release_in_isolated_perfused_guinea_pig_heart_ L2 - https://www.lens.org/lens/search?q=citation_id:1716836 DB - PRIME DP - Unbound Medicine ER -