Tags

Type your tag names separated by a space and hit enter

Anthropometric and metabolic factors and risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans.
Urology 2006; 68(6):1198-205U

Abstract

OBJECTIVES

The relationship between anthropometric and metabolic factors and benign prostatic hyperplasia (BPH) is poorly understood. We investigated the associations of BPH with anthropometric and metabolic parameters in this prospective study of Vietnam War veterans.

METHODS

A total of 1206 participants in the comparison arm of the Air Force Health Study with a median follow-up of 15.6 years were included in this study. The "Ranch Hand" group, occupationally exposed to herbicides, was excluded to eliminate any confounding from exposure to herbicides. BPH was determined by medical record review using the International Classification of Diseases and Related Problems, Ninth Revision. We used Cox proportional hazards regression models for the statistical analysis.

RESULTS

The median age for BPH diagnosis was 58.6 years. On multivariate analyses, increasing age (relative risk [RR] 1.14, 95% confidence interval [CI] 1.12 to 1.17), height (RR 1.02, 95% CI 1.004 to 1.03), and fasting blood glucose (RR 1.004, 95% CI 1.001 to 1.007) were associated with increased risk. The effect of age varied with the duration of follow-up. A greater systolic blood pressure (RR 0.992, 95% CI 0.986 to 0.997) was associated with decreased risk of BPH. A dose-response effect was seen for age, height, and systolic blood pressure. No effect was seen for weight, body mass index, change in weight or body mass index, lipids, thyroid hormone status, or the metabolic syndrome.

CONCLUSIONS

The risk of BPH increased with increasing age, height, and fasting blood glucose levels. The risk was decreased with a greater systolic blood pressure. No relationship was seen between BPH and metabolic syndrome, weight, body mass index, lipid level, or thyroid hormone status.

Authors+Show Affiliations

Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9110, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17169643

Citation

Gupta, Amit, et al. "Anthropometric and Metabolic Factors and Risk of Benign Prostatic Hyperplasia: a Prospective Cohort Study of Air Force Veterans." Urology, vol. 68, no. 6, 2006, pp. 1198-205.
Gupta A, Gupta S, Pavuk M, et al. Anthropometric and metabolic factors and risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. Urology. 2006;68(6):1198-205.
Gupta, A., Gupta, S., Pavuk, M., & Roehrborn, C. G. (2006). Anthropometric and metabolic factors and risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. Urology, 68(6), pp. 1198-205.
Gupta A, et al. Anthropometric and Metabolic Factors and Risk of Benign Prostatic Hyperplasia: a Prospective Cohort Study of Air Force Veterans. Urology. 2006;68(6):1198-205. PubMed PMID: 17169643.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anthropometric and metabolic factors and risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. AU - Gupta,Amit, AU - Gupta,Sachin, AU - Pavuk,Marian, AU - Roehrborn,Claus G, PY - 2006/08/16/received PY - 2006/09/03/revised PY - 2006/09/14/accepted PY - 2006/12/16/pubmed PY - 2007/1/16/medline PY - 2006/12/16/entrez SP - 1198 EP - 205 JF - Urology JO - Urology VL - 68 IS - 6 N2 - OBJECTIVES: The relationship between anthropometric and metabolic factors and benign prostatic hyperplasia (BPH) is poorly understood. We investigated the associations of BPH with anthropometric and metabolic parameters in this prospective study of Vietnam War veterans. METHODS: A total of 1206 participants in the comparison arm of the Air Force Health Study with a median follow-up of 15.6 years were included in this study. The "Ranch Hand" group, occupationally exposed to herbicides, was excluded to eliminate any confounding from exposure to herbicides. BPH was determined by medical record review using the International Classification of Diseases and Related Problems, Ninth Revision. We used Cox proportional hazards regression models for the statistical analysis. RESULTS: The median age for BPH diagnosis was 58.6 years. On multivariate analyses, increasing age (relative risk [RR] 1.14, 95% confidence interval [CI] 1.12 to 1.17), height (RR 1.02, 95% CI 1.004 to 1.03), and fasting blood glucose (RR 1.004, 95% CI 1.001 to 1.007) were associated with increased risk. The effect of age varied with the duration of follow-up. A greater systolic blood pressure (RR 0.992, 95% CI 0.986 to 0.997) was associated with decreased risk of BPH. A dose-response effect was seen for age, height, and systolic blood pressure. No effect was seen for weight, body mass index, change in weight or body mass index, lipids, thyroid hormone status, or the metabolic syndrome. CONCLUSIONS: The risk of BPH increased with increasing age, height, and fasting blood glucose levels. The risk was decreased with a greater systolic blood pressure. No relationship was seen between BPH and metabolic syndrome, weight, body mass index, lipid level, or thyroid hormone status. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/17169643/Anthropometric_and_metabolic_factors_and_risk_of_benign_prostatic_hyperplasia:_a_prospective_cohort_study_of_Air_Force_veterans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(06)02158-3 DB - PRIME DP - Unbound Medicine ER -