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Role of ultraviolet B irradiance and vitamin D in prevention of ovarian cancer.
Am J Prev Med 2006; 31(6):512-4AJ

Abstract

BACKGROUND

There is a north-south gradient in age-adjusted mortality rates of ovarian cancer in the United States, with the highest rates in the Northeast and the lowest in the South through Southwest. This suggests that lower levels of solar irradiance might be associated with higher risk of ovarian cancer. Laboratory findings also suggest that low levels of vitamin D metabolites could play a role in the etiology of ovarian cancer.

METHODS

The association of solar ultraviolet B (UVB) irradiance, stratospheric column ozone, and fertility rates at ages 15 to 19 years with incidence rates of ovarian cancer in 175 countries in 2002 were examined using multiple linear regression in 2006.

RESULTS

Age-adjusted ovarian cancer incidence rates generally were highest in countries located at higher latitudes (R(2)=0.45, p< or =0.01). According to multivariate analysis, UVB irradiance (p< or =0.002) and fertility rates at ages 15 to 19 (p=0.01) were inversely associated with incidence rates, while stratospheric ozone (p< or =0.0008), which reduces transmission of UVB, was positively associated with incidence (R(2)=0.49, p<0.0001).

CONCLUSIONS

Solar UVB irradiance was inversely associated with incidence rates of ovarian cancer in this study, adding new evidence to the theory that vitamin D might play a role in the prevention of ovarian cancer. Cohort studies are needed to confirm this possible association.

Authors+Show Affiliations

Department of Family and Preventive Medicine, University of California-San Diego, La Jolla, California 92093-0631, USA. garlandc@nhrc.navy.milNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17169713

Citation

Garland, Cedric F., et al. "Role of Ultraviolet B Irradiance and Vitamin D in Prevention of Ovarian Cancer." American Journal of Preventive Medicine, vol. 31, no. 6, 2006, pp. 512-4.
Garland CF, Mohr SB, Gorham ED, et al. Role of ultraviolet B irradiance and vitamin D in prevention of ovarian cancer. Am J Prev Med. 2006;31(6):512-4.
Garland, C. F., Mohr, S. B., Gorham, E. D., Grant, W. B., & Garland, F. C. (2006). Role of ultraviolet B irradiance and vitamin D in prevention of ovarian cancer. American Journal of Preventive Medicine, 31(6), pp. 512-4.
Garland CF, et al. Role of Ultraviolet B Irradiance and Vitamin D in Prevention of Ovarian Cancer. Am J Prev Med. 2006;31(6):512-4. PubMed PMID: 17169713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of ultraviolet B irradiance and vitamin D in prevention of ovarian cancer. AU - Garland,Cedric F, AU - Mohr,Sharif B, AU - Gorham,Edward D, AU - Grant,William B, AU - Garland,Frank C, PY - 2006/05/19/received PY - 2006/07/17/revised PY - 2006/08/01/accepted PY - 2006/12/16/pubmed PY - 2007/2/28/medline PY - 2006/12/16/entrez SP - 512 EP - 4 JF - American journal of preventive medicine JO - Am J Prev Med VL - 31 IS - 6 N2 - BACKGROUND: There is a north-south gradient in age-adjusted mortality rates of ovarian cancer in the United States, with the highest rates in the Northeast and the lowest in the South through Southwest. This suggests that lower levels of solar irradiance might be associated with higher risk of ovarian cancer. Laboratory findings also suggest that low levels of vitamin D metabolites could play a role in the etiology of ovarian cancer. METHODS: The association of solar ultraviolet B (UVB) irradiance, stratospheric column ozone, and fertility rates at ages 15 to 19 years with incidence rates of ovarian cancer in 175 countries in 2002 were examined using multiple linear regression in 2006. RESULTS: Age-adjusted ovarian cancer incidence rates generally were highest in countries located at higher latitudes (R(2)=0.45, p< or =0.01). According to multivariate analysis, UVB irradiance (p< or =0.002) and fertility rates at ages 15 to 19 (p=0.01) were inversely associated with incidence rates, while stratospheric ozone (p< or =0.0008), which reduces transmission of UVB, was positively associated with incidence (R(2)=0.49, p<0.0001). CONCLUSIONS: Solar UVB irradiance was inversely associated with incidence rates of ovarian cancer in this study, adding new evidence to the theory that vitamin D might play a role in the prevention of ovarian cancer. Cohort studies are needed to confirm this possible association. SN - 0749-3797 UR - https://www.unboundmedicine.com/medline/citation/17169713/Role_of_ultraviolet_B_irradiance_and_vitamin_D_in_prevention_of_ovarian_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0749-3797(06)00328-X DB - PRIME DP - Unbound Medicine ER -