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Effect of beta-blocker therapy on left atrial function in patients with heart failure: comparison of metoprolol succinate with carvedilol.
Int J Cardiovasc Imaging. 2007 Oct; 23(5):549-55.IJ

Abstract

OBJECTIVE

We aimed to compare the effects of carvedilol and metoprolol succinate on left atrial (LA) function in patients with chronic heart failure.

METHODS

Thirty three patients (6 females, 27 males) who had not received beta blocker treatment previously and whose left ventricular ejection fraction was below 40% were included in this study. LA volumes were measured echocardiographically just before the time of mitral valve opening (V (max)), onset of atrial systole (p-wave at the electrocardiography = V (p)) and mitral valve closure (V (min)) according to the biplane area length method at baseline and in the 3rd month after the administration of beta blockers. NT-proBNP level was measured at the beginning and in the third month of beta blocker treatment. The first group was given carvedilol 6.25 mg/day, the second group was given 12.5 mg/day metoprolol succinate and it was increased to the tolerable maximal dose.

RESULTS

LA diameter and LA V (max), V (p), V (min) decreased significantly both in carvedilol group and metoprolol group after beta blocker theraphy (P < 0.01, : P < 0.01, : P < 0.05, : P < 0.05: for metoprolol, P < 0.001, P < 0.01, P < 0.01, P < 0.01 for carvedilol). But it was increased in conduit volume (P < 0.05 for two groups). LA-passive emptying fraction, LA-active emptying fraction and reservoir fraction were no significant differences both in carvedilol group and metoprolol group after beta blocker theraphy. NT-proBNP levels were found to decrease significantly in both groups after beta blocker treatment (P < 0.001).:

CONCLUSION

Our findings indicate that beta blocker treatment leads to a decrease in LA diameters and volumes, and metoprolol succinate and carvedilol had similar effects on this decrease.

Authors+Show Affiliations

Faculty of Medicine, Department of Cardiology, Ataturk University, Erzurum, Turkey. sarslan@atauni.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17171429

Citation

Arslan, Sakir, et al. "Effect of Beta-blocker Therapy On Left Atrial Function in Patients With Heart Failure: Comparison of Metoprolol Succinate With Carvedilol." The International Journal of Cardiovascular Imaging, vol. 23, no. 5, 2007, pp. 549-55.
Arslan S, Erol MK, Bozkurt E, et al. Effect of beta-blocker therapy on left atrial function in patients with heart failure: comparison of metoprolol succinate with carvedilol. Int J Cardiovasc Imaging. 2007;23(5):549-55.
Arslan, S., Erol, M. K., Bozkurt, E., Acikel, M., Gundogdu, F., Atesal, S., & Senocak, H. (2007). Effect of beta-blocker therapy on left atrial function in patients with heart failure: comparison of metoprolol succinate with carvedilol. The International Journal of Cardiovascular Imaging, 23(5), 549-55.
Arslan S, et al. Effect of Beta-blocker Therapy On Left Atrial Function in Patients With Heart Failure: Comparison of Metoprolol Succinate With Carvedilol. Int J Cardiovasc Imaging. 2007;23(5):549-55. PubMed PMID: 17171429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of beta-blocker therapy on left atrial function in patients with heart failure: comparison of metoprolol succinate with carvedilol. AU - Arslan,Sakir, AU - Erol,Mustafa Kemal, AU - Bozkurt,Engin, AU - Acikel,Mahmut, AU - Gundogdu,Fuat, AU - Atesal,Sebahattin, AU - Senocak,Huseyin, Y1 - 2006/12/14/ PY - 2006/07/19/received PY - 2006/11/13/accepted PY - 2006/12/16/pubmed PY - 2007/12/21/medline PY - 2006/12/16/entrez SP - 549 EP - 55 JF - The international journal of cardiovascular imaging JO - Int J Cardiovasc Imaging VL - 23 IS - 5 N2 - OBJECTIVE: We aimed to compare the effects of carvedilol and metoprolol succinate on left atrial (LA) function in patients with chronic heart failure. METHODS: Thirty three patients (6 females, 27 males) who had not received beta blocker treatment previously and whose left ventricular ejection fraction was below 40% were included in this study. LA volumes were measured echocardiographically just before the time of mitral valve opening (V (max)), onset of atrial systole (p-wave at the electrocardiography = V (p)) and mitral valve closure (V (min)) according to the biplane area length method at baseline and in the 3rd month after the administration of beta blockers. NT-proBNP level was measured at the beginning and in the third month of beta blocker treatment. The first group was given carvedilol 6.25 mg/day, the second group was given 12.5 mg/day metoprolol succinate and it was increased to the tolerable maximal dose. RESULTS: LA diameter and LA V (max), V (p), V (min) decreased significantly both in carvedilol group and metoprolol group after beta blocker theraphy (P < 0.01, : P < 0.01, : P < 0.05, : P < 0.05: for metoprolol, P < 0.001, P < 0.01, P < 0.01, P < 0.01 for carvedilol). But it was increased in conduit volume (P < 0.05 for two groups). LA-passive emptying fraction, LA-active emptying fraction and reservoir fraction were no significant differences both in carvedilol group and metoprolol group after beta blocker theraphy. NT-proBNP levels were found to decrease significantly in both groups after beta blocker treatment (P < 0.001).: CONCLUSION: Our findings indicate that beta blocker treatment leads to a decrease in LA diameters and volumes, and metoprolol succinate and carvedilol had similar effects on this decrease. SN - 1569-5794 UR - https://www.unboundmedicine.com/medline/citation/17171429/Effect_of_beta_blocker_therapy_on_left_atrial_function_in_patients_with_heart_failure:_comparison_of_metoprolol_succinate_with_carvedilol_ L2 - https://doi.org/10.1007/s10554-006-9195-3 DB - PRIME DP - Unbound Medicine ER -