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[Study on serum erythropoietin levels in patients with hematologic malignancies].
Zhonghua Xue Ye Xue Za Zhi. 2006 Aug; 27(8):543-5.ZX

Abstract

OBJECTIVE

To study whether hematologic malignancy patients with anemia have a lower erythropoietin (EPO) response.

METHODS

Serum EPO levels were detected by ELISA in patients with hematologic malignancies and with iron deficiency anemia (IDA). Eighty patients with hematologic malignancies, including 13 multiple myeloma (MM), 7 chronic lymphocytic leukemia (CLL) and 60 non-Hodgkin's lymphoma (NHL) were studied. Thirty of them had anemia(21 NHL,6 MM and 3 CLL). Twenty patients with IDA were studied as the control.

RESULTS

Hematologic malignancy patients with anemia had higher EPO levels [(97.8 +/- 183.9) IU/L] than those with normal Hb values [(27.8 +/- 85.4) IU/L; P <0.01]. In patients with IDA, serum EPO response was inversely correlated with Hb level (r= -0.5, P <0.05) , but no such inverse correlation was found in the hematologic malignancy patients with anemia (r = -0.14). After corrected for Hb level, the serum EPO levels were significantly lower in anemic patients with hematologic malignancies than in IDA patients (P = 0.032) , indicating a decreased EPO response in the former group.

CONCLUSION

Anemia associated with hematologic malignancy might result from an inappropriately low EPO response. EPO treatment for these patients may be beneficial.

Authors+Show Affiliations

Department of Hematology, Peking Union Medical College Hospital, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

17172129

Citation

Han, Bing, et al. "[Study On Serum Erythropoietin Levels in Patients With Hematologic Malignancies]." Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, vol. 27, no. 8, 2006, pp. 543-5.
Han B, Shi YK, Zhu J, et al. [Study on serum erythropoietin levels in patients with hematologic malignancies]. Zhonghua Xue Ye Xue Za Zhi. 2006;27(8):543-5.
Han, B., Shi, Y. K., Zhu, J., He, X. H., Lin, N. J., Li, S. L., & Shen, T. (2006). [Study on serum erythropoietin levels in patients with hematologic malignancies]. Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, 27(8), 543-5.
Han B, et al. [Study On Serum Erythropoietin Levels in Patients With Hematologic Malignancies]. Zhonghua Xue Ye Xue Za Zhi. 2006;27(8):543-5. PubMed PMID: 17172129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on serum erythropoietin levels in patients with hematologic malignancies]. AU - Han,Bing, AU - Shi,Yuan-kai, AU - Zhu,Jun, AU - He,Xiao-hui, AU - Lin,Ning-jing, AU - Li,Shu-lan, AU - Shen,Ti, PY - 2006/12/19/pubmed PY - 2007/9/1/medline PY - 2006/12/19/entrez SP - 543 EP - 5 JF - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi JO - Zhonghua Xue Ye Xue Za Zhi VL - 27 IS - 8 N2 - OBJECTIVE: To study whether hematologic malignancy patients with anemia have a lower erythropoietin (EPO) response. METHODS: Serum EPO levels were detected by ELISA in patients with hematologic malignancies and with iron deficiency anemia (IDA). Eighty patients with hematologic malignancies, including 13 multiple myeloma (MM), 7 chronic lymphocytic leukemia (CLL) and 60 non-Hodgkin's lymphoma (NHL) were studied. Thirty of them had anemia(21 NHL,6 MM and 3 CLL). Twenty patients with IDA were studied as the control. RESULTS: Hematologic malignancy patients with anemia had higher EPO levels [(97.8 +/- 183.9) IU/L] than those with normal Hb values [(27.8 +/- 85.4) IU/L; P <0.01]. In patients with IDA, serum EPO response was inversely correlated with Hb level (r= -0.5, P <0.05) , but no such inverse correlation was found in the hematologic malignancy patients with anemia (r = -0.14). After corrected for Hb level, the serum EPO levels were significantly lower in anemic patients with hematologic malignancies than in IDA patients (P = 0.032) , indicating a decreased EPO response in the former group. CONCLUSION: Anemia associated with hematologic malignancy might result from an inappropriately low EPO response. EPO treatment for these patients may be beneficial. SN - 0253-2727 UR - https://www.unboundmedicine.com/medline/citation/17172129/[Study_on_serum_erythropoietin_levels_in_patients_with_hematologic_malignancies]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0253-2727&amp;year=2006&amp;vol=27&amp;issue=8&amp;fpage=543 DB - PRIME DP - Unbound Medicine ER -