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Effect of selenium supplementation on biochemical markers and outcome in critically ill patients.
Clin Nutr. 2007 Feb; 26(1):41-50.CN

Abstract

BACKGROUND & AIMS

This study aimed to assess the effect of high dose selenium (Se) supplementation on Se status in blood, oxidative stress, thyroid function and possible effects on requirement for renal replacement therapy (RRT) in severely septic patients admitted to the intensive care unit (ICU).

METHODS

This prospective single-centre study was carried out in 40 septic ICU patients who were randomized to high dose Se (Se+ group, N=18 (474, 316, 158 microg/day), each for 3 consecutive days followed by a standard dose of 31.6 microg/day of Se given as sodium selenite whereas the control group (Se-, N=22) received only the standard dose of Se. Plasma Se, glutathione peroxidase (GSH-Px), F2 isoprostanes, thyroid function tests (total T4 and total T3), C-reactive protein (CRP) and red blood cell (RBC) GSH-Px were estimated on day 0, 3, 7, 14.

RESULTS

In the Se+ group, plasma Se increased by day 3 and 7 (P<0.0001) and day 14 (P=0.02), plasma GSH-Px increased by day 3 and 7 (P=0.01) as compared to Se- group. There was a significant negative correlation between plasma Se and SOFA (sepsis related organ failure assessment) (r=-0.36, P=0.03) along with low plasma Se and high CRP at the time of admission. Requirement for renal replacement therapy was not significantly different between the groups.

CONCLUSION

Although high dose Se supplementation increased plasma Se and GSH-Px activity, it did not reduce oxidative damage or the requirement for RRT. Se levels in blood are influenced by redistribution and severity of illness and therefore should be interpreted with caution.

Authors+Show Affiliations

Department of Clinical Chemistry, Royal Liverpool University Hospital, Liverpool L69 3GA, UK. vinmishra@yahoo.co.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17174015

Citation

Mishra, Vinita, et al. "Effect of Selenium Supplementation On Biochemical Markers and Outcome in Critically Ill Patients." Clinical Nutrition (Edinburgh, Scotland), vol. 26, no. 1, 2007, pp. 41-50.
Mishra V, Baines M, Perry SE, et al. Effect of selenium supplementation on biochemical markers and outcome in critically ill patients. Clin Nutr. 2007;26(1):41-50.
Mishra, V., Baines, M., Perry, S. E., McLaughlin, P. J., Carson, J., Wenstone, R., & Shenkin, A. (2007). Effect of selenium supplementation on biochemical markers and outcome in critically ill patients. Clinical Nutrition (Edinburgh, Scotland), 26(1), 41-50.
Mishra V, et al. Effect of Selenium Supplementation On Biochemical Markers and Outcome in Critically Ill Patients. Clin Nutr. 2007;26(1):41-50. PubMed PMID: 17174015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of selenium supplementation on biochemical markers and outcome in critically ill patients. AU - Mishra,Vinita, AU - Baines,Malcolm, AU - Perry,Sara Elizabeth, AU - McLaughlin,Paul Jeremy, AU - Carson,Jeff, AU - Wenstone,Richard, AU - Shenkin,Alan, Y1 - 2006/12/14/ PY - 2006/03/03/received PY - 2006/10/06/revised PY - 2006/10/30/accepted PY - 2006/12/19/pubmed PY - 2007/5/1/medline PY - 2006/12/19/entrez SP - 41 EP - 50 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 26 IS - 1 N2 - BACKGROUND & AIMS: This study aimed to assess the effect of high dose selenium (Se) supplementation on Se status in blood, oxidative stress, thyroid function and possible effects on requirement for renal replacement therapy (RRT) in severely septic patients admitted to the intensive care unit (ICU). METHODS: This prospective single-centre study was carried out in 40 septic ICU patients who were randomized to high dose Se (Se+ group, N=18 (474, 316, 158 microg/day), each for 3 consecutive days followed by a standard dose of 31.6 microg/day of Se given as sodium selenite whereas the control group (Se-, N=22) received only the standard dose of Se. Plasma Se, glutathione peroxidase (GSH-Px), F2 isoprostanes, thyroid function tests (total T4 and total T3), C-reactive protein (CRP) and red blood cell (RBC) GSH-Px were estimated on day 0, 3, 7, 14. RESULTS: In the Se+ group, plasma Se increased by day 3 and 7 (P<0.0001) and day 14 (P=0.02), plasma GSH-Px increased by day 3 and 7 (P=0.01) as compared to Se- group. There was a significant negative correlation between plasma Se and SOFA (sepsis related organ failure assessment) (r=-0.36, P=0.03) along with low plasma Se and high CRP at the time of admission. Requirement for renal replacement therapy was not significantly different between the groups. CONCLUSION: Although high dose Se supplementation increased plasma Se and GSH-Px activity, it did not reduce oxidative damage or the requirement for RRT. Se levels in blood are influenced by redistribution and severity of illness and therefore should be interpreted with caution. SN - 0261-5614 UR - https://www.unboundmedicine.com/medline/citation/17174015/Effect_of_selenium_supplementation_on_biochemical_markers_and_outcome_in_critically_ill_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(06)00195-6 DB - PRIME DP - Unbound Medicine ER -