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The urokinase-type plasminogen activator polymorphism PLAU_1 is a risk factor for APOE-epsilon4 non-carriers in the Italian Alzheimer's disease population and does not affect the plasma Abeta(1-42) level.
Neurobiol Dis. 2007 Mar; 25(3):609-13.ND

Abstract

Sporadic Alzheimer's disease (AD) is the most frequent form of dementia in the elderly. A non-conservative polymorphism in the urokinase-type plasminogen activator gene (PLAU_1=RS2227564) has been analyzed, but data are conflicting on whether it is a risk factor for AD. To clarify whether this genetic variant modifies AD risk in the Italian population, we ran a case-control association study on 192 AD and 126 age-matched controls. We did not find any association between PLAU_1 genotype and AD in the whole AD population, but when we stratified our sample by APOE-epsilon4 status, we found a significant association between PLAU_1 genotype (C/T+T/T) and APOE-epsilon4 negative AD subjects (p=0.02, chi(2)-test). The PLAU_1 genotype did not appear to affect the plasma Abeta42 concentration. Our data support a role for PLAU_1 as an independent genetic risk factor for AD in the Italian population for those subjects who do not have the APOE-epsilon4 allele.

Authors+Show Affiliations

Department of Neuroscience, Mario Negri Institute for Pharmacological Research, via Eritrea 62, 20157 Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17174555

Citation

Pesaresi, Marzia, et al. "The Urokinase-type Plasminogen Activator Polymorphism PLAU_1 Is a Risk Factor for APOE-epsilon4 Non-carriers in the Italian Alzheimer's Disease Population and Does Not Affect the Plasma Abeta(1-42) Level." Neurobiology of Disease, vol. 25, no. 3, 2007, pp. 609-13.
Pesaresi M, Batelli S, Prato F, et al. The urokinase-type plasminogen activator polymorphism PLAU_1 is a risk factor for APOE-epsilon4 non-carriers in the Italian Alzheimer's disease population and does not affect the plasma Abeta(1-42) level. Neurobiol Dis. 2007;25(3):609-13.
Pesaresi, M., Batelli, S., Prato, F., Polito, L., Lovati, C., Scarpini, E., Quadri, P., Mariani, C., Albani, D., & Forloni, G. (2007). The urokinase-type plasminogen activator polymorphism PLAU_1 is a risk factor for APOE-epsilon4 non-carriers in the Italian Alzheimer's disease population and does not affect the plasma Abeta(1-42) level. Neurobiology of Disease, 25(3), 609-13.
Pesaresi M, et al. The Urokinase-type Plasminogen Activator Polymorphism PLAU_1 Is a Risk Factor for APOE-epsilon4 Non-carriers in the Italian Alzheimer's Disease Population and Does Not Affect the Plasma Abeta(1-42) Level. Neurobiol Dis. 2007;25(3):609-13. PubMed PMID: 17174555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The urokinase-type plasminogen activator polymorphism PLAU_1 is a risk factor for APOE-epsilon4 non-carriers in the Italian Alzheimer's disease population and does not affect the plasma Abeta(1-42) level. AU - Pesaresi,Marzia, AU - Batelli,Sara, AU - Prato,Francesca, AU - Polito,Letizia, AU - Lovati,Carlo, AU - Scarpini,Elio, AU - Quadri,Pierluigi, AU - Mariani,Claudio, AU - Albani,Diego, AU - Forloni,Gianluigi, Y1 - 2006/12/15/ PY - 2006/07/06/received PY - 2006/09/28/revised PY - 2006/10/29/accepted PY - 2006/12/19/pubmed PY - 2007/5/18/medline PY - 2006/12/19/entrez SP - 609 EP - 13 JF - Neurobiology of disease JO - Neurobiol Dis VL - 25 IS - 3 N2 - Sporadic Alzheimer's disease (AD) is the most frequent form of dementia in the elderly. A non-conservative polymorphism in the urokinase-type plasminogen activator gene (PLAU_1=RS2227564) has been analyzed, but data are conflicting on whether it is a risk factor for AD. To clarify whether this genetic variant modifies AD risk in the Italian population, we ran a case-control association study on 192 AD and 126 age-matched controls. We did not find any association between PLAU_1 genotype and AD in the whole AD population, but when we stratified our sample by APOE-epsilon4 status, we found a significant association between PLAU_1 genotype (C/T+T/T) and APOE-epsilon4 negative AD subjects (p=0.02, chi(2)-test). The PLAU_1 genotype did not appear to affect the plasma Abeta42 concentration. Our data support a role for PLAU_1 as an independent genetic risk factor for AD in the Italian population for those subjects who do not have the APOE-epsilon4 allele. SN - 0969-9961 UR - https://www.unboundmedicine.com/medline/citation/17174555/The_urokinase_type_plasminogen_activator_polymorphism_PLAU_1_is_a_risk_factor_for_APOE_epsilon4_non_carriers_in_the_Italian_Alzheimer's_disease_population_and_does_not_affect_the_plasma_Abeta_1_42__level_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0969-9961(06)00295-6 DB - PRIME DP - Unbound Medicine ER -