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Lipid-induced colonic hypersensitivity in the irritable bowel syndrome: the role of bowel habit, sex, and psychologic factors.
Clin Gastroenterol Hepatol. 2007 Feb; 5(2):201-8.CG

Abstract

BACKGROUND & AIMS

Duodenal lipid infusion increases colonic hypersensitivity in irritable bowel syndrome (IBS). Whether this is affected by bowel habit, psychologic factors, or sex is unknown.

METHODS

We included 61 patients with IBS (50 women, 11 men), 25 with diarrhea-predominant IBS, 17 with constipation-predominant IBS, 19 with alternating-type IBS, and 20 healthy controls (15 women, 5 men). A colonic distension trial was performed with a barostat before and after a 1-hour duodenal lipid infusion (3 kcal/min). Colonic thresholds, colonic tone, and the viscerosomatic referral pattern were assessed and compared between groups. Patients also completed the Hospital Anxiety and Depression scale.

RESULTS

The reduction in colonic pressure thresholds after vs before duodenal lipids was greater in patients than in controls for discomfort (P = .006) and pain (P < .0001). An increased viscerosomatic referral area for pain and discomfort during colonic distensions after vs before duodenal lipids was observed in patients but not in controls. The response was similar in IBS subgroups based on the predominant bowel habit, in patients with vs without anxiety and/or depression, and in women and men with IBS. The colonic tone response during lipid infusion was similar in IBS patients and controls, and in the different IBS subgroups.

CONCLUSIONS

IBS patients show increased colonic sensitivity and altered viscerosomatic referral pattern after duodenal lipids. This response is largely unaffected by the predominant bowel habit, psychologic factors, or sex, but seems to be related to IBS per se.

Authors+Show Affiliations

Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg, Sweden. magnus.simren@medicine.gu.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17174611

Citation

Simrén, Magnus, et al. "Lipid-induced Colonic Hypersensitivity in the Irritable Bowel Syndrome: the Role of Bowel Habit, Sex, and Psychologic Factors." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 5, no. 2, 2007, pp. 201-8.
Simrén M, Abrahamsson H, Björnsson ES. Lipid-induced colonic hypersensitivity in the irritable bowel syndrome: the role of bowel habit, sex, and psychologic factors. Clin Gastroenterol Hepatol. 2007;5(2):201-8.
Simrén, M., Abrahamsson, H., & Björnsson, E. S. (2007). Lipid-induced colonic hypersensitivity in the irritable bowel syndrome: the role of bowel habit, sex, and psychologic factors. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 5(2), 201-8.
Simrén M, Abrahamsson H, Björnsson ES. Lipid-induced Colonic Hypersensitivity in the Irritable Bowel Syndrome: the Role of Bowel Habit, Sex, and Psychologic Factors. Clin Gastroenterol Hepatol. 2007;5(2):201-8. PubMed PMID: 17174611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid-induced colonic hypersensitivity in the irritable bowel syndrome: the role of bowel habit, sex, and psychologic factors. AU - Simrén,Magnus, AU - Abrahamsson,Hasse, AU - Björnsson,Einar S, Y1 - 2006/12/14/ PY - 2006/12/19/pubmed PY - 2007/3/28/medline PY - 2006/12/19/entrez SP - 201 EP - 8 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin Gastroenterol Hepatol VL - 5 IS - 2 N2 - BACKGROUND & AIMS: Duodenal lipid infusion increases colonic hypersensitivity in irritable bowel syndrome (IBS). Whether this is affected by bowel habit, psychologic factors, or sex is unknown. METHODS: We included 61 patients with IBS (50 women, 11 men), 25 with diarrhea-predominant IBS, 17 with constipation-predominant IBS, 19 with alternating-type IBS, and 20 healthy controls (15 women, 5 men). A colonic distension trial was performed with a barostat before and after a 1-hour duodenal lipid infusion (3 kcal/min). Colonic thresholds, colonic tone, and the viscerosomatic referral pattern were assessed and compared between groups. Patients also completed the Hospital Anxiety and Depression scale. RESULTS: The reduction in colonic pressure thresholds after vs before duodenal lipids was greater in patients than in controls for discomfort (P = .006) and pain (P < .0001). An increased viscerosomatic referral area for pain and discomfort during colonic distensions after vs before duodenal lipids was observed in patients but not in controls. The response was similar in IBS subgroups based on the predominant bowel habit, in patients with vs without anxiety and/or depression, and in women and men with IBS. The colonic tone response during lipid infusion was similar in IBS patients and controls, and in the different IBS subgroups. CONCLUSIONS: IBS patients show increased colonic sensitivity and altered viscerosomatic referral pattern after duodenal lipids. This response is largely unaffected by the predominant bowel habit, psychologic factors, or sex, but seems to be related to IBS per se. SN - 1542-7714 UR - https://www.unboundmedicine.com/medline/citation/17174611/Lipid_induced_colonic_hypersensitivity_in_the_irritable_bowel_syndrome:_the_role_of_bowel_habit_sex_and_psychologic_factors_ DB - PRIME DP - Unbound Medicine ER -