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Comparison of buccal and intramuscular dexmedetomidine premedication for arthroscopic knee surgery.
J Clin Anesth 2006; 18(8):589-93JC

Abstract

STUDY OBJECTIVE

To compare the sedative, anxiolytic, analgesic, hemodynamic, and respiratory effects of buccal dexmedetomidine with intramuscular (IM) dexmedetomidine for premedication in patients undergoing arthroscopic knee surgery during spinal anesthesia.

DESIGN

Randomized, placebo-controlled trial.

SETTING

University medical center.

PATIENTS

75 ASA physical status I and II patients undergoing arthroscopic knee surgery with spinal anesthesia.

INTERVENTIONS

Patients were randomized to one of three groups for premedication: group B, buccal dexmedetomidine 2.5 microg kg(-1); group IM, IM dexmedetomidine 2.5 microg kg(-1); and group P, buccal 0.9% and NaCl 2 mL.

MEASUREMENTS

Noninvasive blood pressure, heart rate, respiratory rate, and peripheral oxygen saturation were recorded. Sedation and anxiety levels were consecutively assessed with Ramsay sedation scores and Visual Analog Scale (VAS) scores of anxiety before premedication, before spinal anesthesia, during surgery, and at the end of surgery. Two, 4, and 8 hours after surgery, sedation levels, postoperative VAS pain scores, and consumption of analgesics (diclofenac sodium) were recorded.

MAIN RESULTS

Before spinal anesthesia, during surgery, and at the end of surgery, sedation and anxiety scores of the patients receiving buccal or IM dexmedetomidine were, respectively, higher and lower than in group P. Patients receiving buccal dexmedetomidine (group B) had lower requirement of diclofenac sodium than group P and lower pain scores than groups P and IM. Mild hypotension and bradycardia were observed in the buccal and IM dexmedetomidine patients.

CONCLUSIONS

Buccal dexmedetomidine for premedication in arthroscopic knee surgery provided equal levels of sedation and anxiolysis, and more evident analgesia compared with IM dexmedetomidine.

Authors+Show Affiliations

Department of Anesthesiology, Suleyman Demirel University School of Medicine, Isparta 32260, Turkey. dilek@med.sdu.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17175428

Citation

Karaaslan, Dilek, et al. "Comparison of Buccal and Intramuscular Dexmedetomidine Premedication for Arthroscopic Knee Surgery." Journal of Clinical Anesthesia, vol. 18, no. 8, 2006, pp. 589-93.
Karaaslan D, Peker TT, Alaca A, et al. Comparison of buccal and intramuscular dexmedetomidine premedication for arthroscopic knee surgery. J Clin Anesth. 2006;18(8):589-93.
Karaaslan, D., Peker, T. T., Alaca, A., Ozmen, S., Kirdemir, P., Yorgancigil, H., & Baydar, M. L. (2006). Comparison of buccal and intramuscular dexmedetomidine premedication for arthroscopic knee surgery. Journal of Clinical Anesthesia, 18(8), pp. 589-93.
Karaaslan D, et al. Comparison of Buccal and Intramuscular Dexmedetomidine Premedication for Arthroscopic Knee Surgery. J Clin Anesth. 2006;18(8):589-93. PubMed PMID: 17175428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of buccal and intramuscular dexmedetomidine premedication for arthroscopic knee surgery. AU - Karaaslan,Dilek, AU - Peker,Tulay Tuncer, AU - Alaca,Adnan, AU - Ozmen,Sadik, AU - Kirdemir,Pakize, AU - Yorgancigil,Huseyin, AU - Baydar,Metin Lutfi, PY - 2005/12/16/received PY - 2006/03/22/revised PY - 2006/03/22/accepted PY - 2006/12/19/pubmed PY - 2007/4/5/medline PY - 2006/12/19/entrez SP - 589 EP - 93 JF - Journal of clinical anesthesia JO - J Clin Anesth VL - 18 IS - 8 N2 - STUDY OBJECTIVE: To compare the sedative, anxiolytic, analgesic, hemodynamic, and respiratory effects of buccal dexmedetomidine with intramuscular (IM) dexmedetomidine for premedication in patients undergoing arthroscopic knee surgery during spinal anesthesia. DESIGN: Randomized, placebo-controlled trial. SETTING: University medical center. PATIENTS: 75 ASA physical status I and II patients undergoing arthroscopic knee surgery with spinal anesthesia. INTERVENTIONS: Patients were randomized to one of three groups for premedication: group B, buccal dexmedetomidine 2.5 microg kg(-1); group IM, IM dexmedetomidine 2.5 microg kg(-1); and group P, buccal 0.9% and NaCl 2 mL. MEASUREMENTS: Noninvasive blood pressure, heart rate, respiratory rate, and peripheral oxygen saturation were recorded. Sedation and anxiety levels were consecutively assessed with Ramsay sedation scores and Visual Analog Scale (VAS) scores of anxiety before premedication, before spinal anesthesia, during surgery, and at the end of surgery. Two, 4, and 8 hours after surgery, sedation levels, postoperative VAS pain scores, and consumption of analgesics (diclofenac sodium) were recorded. MAIN RESULTS: Before spinal anesthesia, during surgery, and at the end of surgery, sedation and anxiety scores of the patients receiving buccal or IM dexmedetomidine were, respectively, higher and lower than in group P. Patients receiving buccal dexmedetomidine (group B) had lower requirement of diclofenac sodium than group P and lower pain scores than groups P and IM. Mild hypotension and bradycardia were observed in the buccal and IM dexmedetomidine patients. CONCLUSIONS: Buccal dexmedetomidine for premedication in arthroscopic knee surgery provided equal levels of sedation and anxiolysis, and more evident analgesia compared with IM dexmedetomidine. SN - 0952-8180 UR - https://www.unboundmedicine.com/medline/citation/17175428/Comparison_of_buccal_and_intramuscular_dexmedetomidine_premedication_for_arthroscopic_knee_surgery_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-8180(06)00221-2 DB - PRIME DP - Unbound Medicine ER -