Tags

Type your tag names separated by a space and hit enter

Effector and regulatory cells in autoimmune oophoritis elicited by neonatal thymectomy.
J Immunol. 1991 Nov 01; 147(9):2928-33.JI

Abstract

(C57BL/6 x A/J)F1 (B6AF1) mice thymectomized between days 1 and 4 of age develop autoimmune oophoritis (D3TX oophoritis) 4 to 6 wk later. Oophoritis can be adoptively transferred to young recipients, and the disease in D3TX mice is prevented by reconstitution with normal adult spleen cells. The present study was further defined the nature of the effector and suppressor cells. Contrary to an earlier report, oophoritis is transferred to syngeneic and not allogeneic recipients. The spleen cells from D3TX mice when stimulated in vitro with Con A, also transfer oophoritis to adult recipients. The effector cells are CD4+: oophoritis transfer is abrogated by CD4 antibody and not by CD8 antibody and C. Spleen cells from D3TX male mice transfer disease less efficiently than female cells, thus endogenous ovarian Ag may be required for activation of effector T cells. T cells from normal adult spleen that suppress D3TX oophoritis also appear to be of CD4+ phenotype. These cells are likely to be derived from adult thymus because adult thymocytes also suppress D3TX disease. We were unable to substantiate the earlier claim that suppressor cells in normal mice are ovarian Ag specific. Thus male and female spleen cells suppress disease with comparable efficiency, and deprivation of endogenous ovarian Ag by neonatal ovariectomy of cell donors had no observable effect on disease suppression.

Authors+Show Affiliations

Department of Pathology and Medicine, Washington University School of Medicine, St Louis, MO 63110.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1717580

Citation

Smith, H, et al. "Effector and Regulatory Cells in Autoimmune Oophoritis Elicited By Neonatal Thymectomy." Journal of Immunology (Baltimore, Md. : 1950), vol. 147, no. 9, 1991, pp. 2928-33.
Smith H, Sakamoto Y, Kasai K, et al. Effector and regulatory cells in autoimmune oophoritis elicited by neonatal thymectomy. J Immunol. 1991;147(9):2928-33.
Smith, H., Sakamoto, Y., Kasai, K., & Tung, K. S. (1991). Effector and regulatory cells in autoimmune oophoritis elicited by neonatal thymectomy. Journal of Immunology (Baltimore, Md. : 1950), 147(9), 2928-33.
Smith H, et al. Effector and Regulatory Cells in Autoimmune Oophoritis Elicited By Neonatal Thymectomy. J Immunol. 1991 Nov 1;147(9):2928-33. PubMed PMID: 1717580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effector and regulatory cells in autoimmune oophoritis elicited by neonatal thymectomy. AU - Smith,H, AU - Sakamoto,Y, AU - Kasai,K, AU - Tung,K S, PY - 1991/11/1/pubmed PY - 1991/11/1/medline PY - 1991/11/1/entrez SP - 2928 EP - 33 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J. Immunol. VL - 147 IS - 9 N2 - (C57BL/6 x A/J)F1 (B6AF1) mice thymectomized between days 1 and 4 of age develop autoimmune oophoritis (D3TX oophoritis) 4 to 6 wk later. Oophoritis can be adoptively transferred to young recipients, and the disease in D3TX mice is prevented by reconstitution with normal adult spleen cells. The present study was further defined the nature of the effector and suppressor cells. Contrary to an earlier report, oophoritis is transferred to syngeneic and not allogeneic recipients. The spleen cells from D3TX mice when stimulated in vitro with Con A, also transfer oophoritis to adult recipients. The effector cells are CD4+: oophoritis transfer is abrogated by CD4 antibody and not by CD8 antibody and C. Spleen cells from D3TX male mice transfer disease less efficiently than female cells, thus endogenous ovarian Ag may be required for activation of effector T cells. T cells from normal adult spleen that suppress D3TX oophoritis also appear to be of CD4+ phenotype. These cells are likely to be derived from adult thymus because adult thymocytes also suppress D3TX disease. We were unable to substantiate the earlier claim that suppressor cells in normal mice are ovarian Ag specific. Thus male and female spleen cells suppress disease with comparable efficiency, and deprivation of endogenous ovarian Ag by neonatal ovariectomy of cell donors had no observable effect on disease suppression. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/1717580/Effector_and_regulatory_cells_in_autoimmune_oophoritis_elicited_by_neonatal_thymectomy_ L2 - http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=1717580 DB - PRIME DP - Unbound Medicine ER -