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[Identification of lithogenic risk factors by a simplified first-line laboratory assessment in urinary calculi patients].
Prog Urol. 2006 Nov; 16(5):542-5.PU

Abstract

INTRODUCTION

A simplified first-line laboratory assessment is recommended by the Stones Committee of the Association Française d'Urologie (CLAFU) right from the first episode of renal stones to detect any lithogenic risk factors. This study was designed to evaluate the feasibility of this assessment in urology, to specify the frequency of risk factors and to compare the results between first stone formers and recurrent stone formers.

MATERIAL AND METHODS

This prospective study included patients with a first stone or recurrent stones with no previous laboratory assessment. Known cases of secondary stones were excluded. The stone or fragments had to be analysed by infrared spectrophotometry. In addition to the usual assessment, the first-line laboratory assessment was performed two to three months after the acute episode with a blood test (calcium, phosphorus, uric acid and creatinine), 24-hour urine collection (volume, calcium, uric acid, urea, creatinine, sodium) and first morning urine sample (pH, density, crystals).

RESULTS

The results are based on 115 of the 204 patients included (69 first stones, 46 recurrent stones). The assessment was performed and interpreted easily, except for collection of stone fragments. Infrared spectrophotometry was performed in only 49 patients. Whewellite was the most frequent crystalline structure. No patients presented hyperparathyroidism or renal failure. In 69% of cases, the urinary assessment identified one or several risk factors, with insufficient diuresis (42%), hypercalciuria (29%), hypernatriuria (41%), high urinary urea (29%), and hyperuricuria (20%). 25% of patients had a single abnormality, 20% had two abnormalities, the most frequent combination being hypercalciuria-hypernatriuria, and 11% had 4 or more abnormalities. Comparison of first stone formers and recurrent stone formers did not reveal any difference in the frequency of lithogenic risk factors.

CONCLUSION

This easy to perform assessment identified lithogenic risk factors in many cases, in both first stone formers and recurrent stone formers, that can guide the prevention of recurrent stones.

Authors+Show Affiliations

Clinique Urologique, Hôtel-Dieu, Nantes, France. pglemain@chu-nantes.frNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

17175947

Citation

Glémain, Pascal, and Denis Prunet. "[Identification of Lithogenic Risk Factors By a Simplified First-line Laboratory Assessment in Urinary Calculi Patients]." Progres En Urologie : Journal De l'Association Francaise D'urologie Et De La Societe Francaise D'urologie, vol. 16, no. 5, 2006, pp. 542-5.
Glémain P, Prunet D. [Identification of lithogenic risk factors by a simplified first-line laboratory assessment in urinary calculi patients]. Prog Urol. 2006;16(5):542-5.
Glémain, P., & Prunet, D. (2006). [Identification of lithogenic risk factors by a simplified first-line laboratory assessment in urinary calculi patients]. Progres En Urologie : Journal De l'Association Francaise D'urologie Et De La Societe Francaise D'urologie, 16(5), 542-5.
Glémain P, Prunet D. [Identification of Lithogenic Risk Factors By a Simplified First-line Laboratory Assessment in Urinary Calculi Patients]. Prog Urol. 2006;16(5):542-5. PubMed PMID: 17175947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Identification of lithogenic risk factors by a simplified first-line laboratory assessment in urinary calculi patients]. AU - Glémain,Pascal, AU - Prunet,Denis, PY - 2006/12/21/pubmed PY - 2007/1/31/medline PY - 2006/12/21/entrez SP - 542 EP - 5 JF - Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie JO - Prog. Urol. VL - 16 IS - 5 N2 - INTRODUCTION: A simplified first-line laboratory assessment is recommended by the Stones Committee of the Association Française d'Urologie (CLAFU) right from the first episode of renal stones to detect any lithogenic risk factors. This study was designed to evaluate the feasibility of this assessment in urology, to specify the frequency of risk factors and to compare the results between first stone formers and recurrent stone formers. MATERIAL AND METHODS: This prospective study included patients with a first stone or recurrent stones with no previous laboratory assessment. Known cases of secondary stones were excluded. The stone or fragments had to be analysed by infrared spectrophotometry. In addition to the usual assessment, the first-line laboratory assessment was performed two to three months after the acute episode with a blood test (calcium, phosphorus, uric acid and creatinine), 24-hour urine collection (volume, calcium, uric acid, urea, creatinine, sodium) and first morning urine sample (pH, density, crystals). RESULTS: The results are based on 115 of the 204 patients included (69 first stones, 46 recurrent stones). The assessment was performed and interpreted easily, except for collection of stone fragments. Infrared spectrophotometry was performed in only 49 patients. Whewellite was the most frequent crystalline structure. No patients presented hyperparathyroidism or renal failure. In 69% of cases, the urinary assessment identified one or several risk factors, with insufficient diuresis (42%), hypercalciuria (29%), hypernatriuria (41%), high urinary urea (29%), and hyperuricuria (20%). 25% of patients had a single abnormality, 20% had two abnormalities, the most frequent combination being hypercalciuria-hypernatriuria, and 11% had 4 or more abnormalities. Comparison of first stone formers and recurrent stone formers did not reveal any difference in the frequency of lithogenic risk factors. CONCLUSION: This easy to perform assessment identified lithogenic risk factors in many cases, in both first stone formers and recurrent stone formers, that can guide the prevention of recurrent stones. SN - 1166-7087 UR - https://www.unboundmedicine.com/medline/citation/17175947/[Identification_of_lithogenic_risk_factors_by_a_simplified_first_line_laboratory_assessment_in_urinary_calculi_patients]_ DB - PRIME DP - Unbound Medicine ER -
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