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Relationship between calcium, lactose, vitamin D, and dairy products and ovarian cancer.

Abstract

Few prospective studies of the relationship between intake of dairy foods, calcium, vitamin D, and lactose and ovarian cancer have been conducted, and results have been largely inconsistent. Two recent studies found significant increased risk with frequent dairy consumption and perhaps with high intakes of calcium or lactose. The authors investigated the association between these foods and nutrients and ovarian cancer risk among 31,925 subjects in the Breast Cancer Detection Demonstration Project follow-up cohort. Multivariable (MV) relative risks (RRs) adjusted for age, parity, and other factors were estimated using Cox proportional hazards models. Over an average follow-up of 8.3 yr, 146 incident ovarian cancer cases were confirmed. Higher intakes of total dairy food (comparing four or more servings per day vs. less than one serving per day) were associated with a statistically significant decreased risk of ovarian cancer, although the trend was not significant (MV RR = 0.42; 95% confidence interval (CI) = 0.20-0.89; P for trend = 0.07). Comparing extreme quartiles, we observed a statistically nonsignificant inverse association between high dietary calcium intake and ovarian cancer (RR = 0.67; 95% CI = 0.43, 1.04; P for trend = 0.08). No statistically significant relations were found for consumption of specific dairy foods, lactose, or vitamin D and ovarian cancer risk. The possibility of a decreased risk of ovarian cancer for dietary calcium merits further evaluation.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. dkoralek@unc.edu

    , , , , ,

    Source

    Nutrition and cancer 56:1 2006 pg 22-30

    MeSH

    Calcium, Dietary
    Confidence Intervals
    Confounding Factors (Epidemiology)
    Dairy Products
    Diet
    Diet Surveys
    Female
    Follow-Up Studies
    Humans
    Incidence
    Lactose
    Menopause
    Middle Aged
    Multivariate Analysis
    Odds Ratio
    Ovarian Neoplasms
    Proportional Hazards Models
    Risk Factors
    Surveys and Questionnaires
    United States
    Vitamin D

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    17176214

    Citation

    Koralek, Daniel O., et al. "Relationship Between Calcium, Lactose, Vitamin D, and Dairy Products and Ovarian Cancer." Nutrition and Cancer, vol. 56, no. 1, 2006, pp. 22-30.
    Koralek DO, Bertone-Johnson ER, Leitzmann MF, et al. Relationship between calcium, lactose, vitamin D, and dairy products and ovarian cancer. Nutr Cancer. 2006;56(1):22-30.
    Koralek, D. O., Bertone-Johnson, E. R., Leitzmann, M. F., Sturgeon, S. R., Lacey, J. V., Schairer, C., & Schatzkin, A. (2006). Relationship between calcium, lactose, vitamin D, and dairy products and ovarian cancer. Nutrition and Cancer, 56(1), pp. 22-30.
    Koralek DO, et al. Relationship Between Calcium, Lactose, Vitamin D, and Dairy Products and Ovarian Cancer. Nutr Cancer. 2006;56(1):22-30. PubMed PMID: 17176214.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Relationship between calcium, lactose, vitamin D, and dairy products and ovarian cancer. AU - Koralek,Daniel O, AU - Bertone-Johnson,Elizabeth R, AU - Leitzmann,Michael F, AU - Sturgeon,Susan R, AU - Lacey,James V,Jr AU - Schairer,Catherine, AU - Schatzkin,Arthur, PY - 2006/12/21/pubmed PY - 2007/3/3/medline PY - 2006/12/21/entrez SP - 22 EP - 30 JF - Nutrition and cancer JO - Nutr Cancer VL - 56 IS - 1 N2 - Few prospective studies of the relationship between intake of dairy foods, calcium, vitamin D, and lactose and ovarian cancer have been conducted, and results have been largely inconsistent. Two recent studies found significant increased risk with frequent dairy consumption and perhaps with high intakes of calcium or lactose. The authors investigated the association between these foods and nutrients and ovarian cancer risk among 31,925 subjects in the Breast Cancer Detection Demonstration Project follow-up cohort. Multivariable (MV) relative risks (RRs) adjusted for age, parity, and other factors were estimated using Cox proportional hazards models. Over an average follow-up of 8.3 yr, 146 incident ovarian cancer cases were confirmed. Higher intakes of total dairy food (comparing four or more servings per day vs. less than one serving per day) were associated with a statistically significant decreased risk of ovarian cancer, although the trend was not significant (MV RR = 0.42; 95% confidence interval (CI) = 0.20-0.89; P for trend = 0.07). Comparing extreme quartiles, we observed a statistically nonsignificant inverse association between high dietary calcium intake and ovarian cancer (RR = 0.67; 95% CI = 0.43, 1.04; P for trend = 0.08). No statistically significant relations were found for consumption of specific dairy foods, lactose, or vitamin D and ovarian cancer risk. The possibility of a decreased risk of ovarian cancer for dietary calcium merits further evaluation. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/17176214/Relationship_between_calcium_lactose_vitamin_D_and_dairy_products_and_ovarian_cancer_ L2 - http://www.tandfonline.com/doi/full/10.1207/s15327914nc5601_4 DB - PRIME DP - Unbound Medicine ER -