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Intestinal bifidobacteria that produce trans-9, trans-11 conjugated linoleic acid: a fatty acid with antiproliferative activity against human colon SW480 and HT-29 cancer cells.
Nutr Cancer. 2006; 56(1):95-102.NC

Abstract

Bifidobacterium breve species of human intestinal origin have the ability to synthesize cis-9, trans-11 (c9, t11) conjugated linoleic acid (CLA) from free linoleic acid. In this study, the ability of Bifidobacterium species to isomerize C(18) polyunsaturated fatty acids was investigated, and the antiproliferative activities of the two main microbially produced CLA isomers were assessed. Linoleic acid was converted principally to c9, t11 CLA and lesser amounts of t9, t11 CLA, whereas c9, t11 CLA was converted mainly to t9, t11 CLA. Likewise, t10, c12 CLA was converted principally to t9, t11 CLA, which was incorporated into the bacterial cell membranes. To examine the antiproliferative effect of the two main CLA isomers formed, SW480 and HT-29 human colon cancer cells were cultured in the presence of c9, t11 CLA and t9, t11 CLA. The t9, t11 CLA had a more potent antiproliferative effect than c9, t11 CLA. It is tempting to suggest that the ability of Bifidobacterium to produce such bioactive metabolites may be associated with the beneficial effects of bifidobacteria present in the human gastrointestinal tract.

Authors+Show Affiliations

Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17176223

Citation

Coakley, Mairéad, et al. "Intestinal Bifidobacteria That Produce Trans-9, Trans-11 Conjugated Linoleic Acid: a Fatty Acid With Antiproliferative Activity Against Human Colon SW480 and HT-29 Cancer Cells." Nutrition and Cancer, vol. 56, no. 1, 2006, pp. 95-102.
Coakley M, Johnson MC, McGrath E, et al. Intestinal bifidobacteria that produce trans-9, trans-11 conjugated linoleic acid: a fatty acid with antiproliferative activity against human colon SW480 and HT-29 cancer cells. Nutr Cancer. 2006;56(1):95-102.
Coakley, M., Johnson, M. C., McGrath, E., Rahman, S., Ross, R. P., Fitzgerald, G. F., Devery, R., & Stanton, C. (2006). Intestinal bifidobacteria that produce trans-9, trans-11 conjugated linoleic acid: a fatty acid with antiproliferative activity against human colon SW480 and HT-29 cancer cells. Nutrition and Cancer, 56(1), 95-102.
Coakley M, et al. Intestinal Bifidobacteria That Produce Trans-9, Trans-11 Conjugated Linoleic Acid: a Fatty Acid With Antiproliferative Activity Against Human Colon SW480 and HT-29 Cancer Cells. Nutr Cancer. 2006;56(1):95-102. PubMed PMID: 17176223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intestinal bifidobacteria that produce trans-9, trans-11 conjugated linoleic acid: a fatty acid with antiproliferative activity against human colon SW480 and HT-29 cancer cells. AU - Coakley,Mairéad, AU - Johnson,Mark C, AU - McGrath,Emma, AU - Rahman,Shafiqur, AU - Ross,R Paul, AU - Fitzgerald,Gerald F, AU - Devery,Rosaleen, AU - Stanton,Catherine, PY - 2006/12/21/pubmed PY - 2007/3/3/medline PY - 2006/12/21/entrez SP - 95 EP - 102 JF - Nutrition and cancer JO - Nutr Cancer VL - 56 IS - 1 N2 - Bifidobacterium breve species of human intestinal origin have the ability to synthesize cis-9, trans-11 (c9, t11) conjugated linoleic acid (CLA) from free linoleic acid. In this study, the ability of Bifidobacterium species to isomerize C(18) polyunsaturated fatty acids was investigated, and the antiproliferative activities of the two main microbially produced CLA isomers were assessed. Linoleic acid was converted principally to c9, t11 CLA and lesser amounts of t9, t11 CLA, whereas c9, t11 CLA was converted mainly to t9, t11 CLA. Likewise, t10, c12 CLA was converted principally to t9, t11 CLA, which was incorporated into the bacterial cell membranes. To examine the antiproliferative effect of the two main CLA isomers formed, SW480 and HT-29 human colon cancer cells were cultured in the presence of c9, t11 CLA and t9, t11 CLA. The t9, t11 CLA had a more potent antiproliferative effect than c9, t11 CLA. It is tempting to suggest that the ability of Bifidobacterium to produce such bioactive metabolites may be associated with the beneficial effects of bifidobacteria present in the human gastrointestinal tract. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/17176223/Intestinal_bifidobacteria_that_produce_trans_9_trans_11_conjugated_linoleic_acid:_a_fatty_acid_with_antiproliferative_activity_against_human_colon_SW480_and_HT_29_cancer_cells_ L2 - https://www.tandfonline.com/doi/full/10.1207/s15327914nc5601_13 DB - PRIME DP - Unbound Medicine ER -