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[Role of mitochondria in reglulation of endothelial cell hyperpolarization to acetylcholine].
Fiziol Zh. 2006; 52(5):6-11.FZ

Abstract

We investigated the regulation of sustained endothelial hyperpolarization to acetylcholine in the rat aortic endothelial cells by mitochondria. Protonofore CCCP and rotenone, an electron transport chain complex I inhibitor, agents that cause mitochondria depolarization, inhibited the sustained hyperpolarization of endothelial cells. This effect was unlikely to be mediated by the free radicals since hydrogen peroxide was shown to hyperpolarize endothelial cells. It is concluded that mitochondrial Ca2+ uptake is essential in prolongation of endothelial hyperpolarization to acetylcholine.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

ukr

PubMed ID

17176833

Citation

Bondarenko, O I., and V F. Sahach. "[Role of Mitochondria in Reglulation of Endothelial Cell Hyperpolarization to Acetylcholine]." Fiziolohichnyi Zhurnal (Kiev, Ukraine : 1994), vol. 52, no. 5, 2006, pp. 6-11.
Bondarenko OI, Sahach VF. [Role of mitochondria in reglulation of endothelial cell hyperpolarization to acetylcholine]. Fiziol Zh. 2006;52(5):6-11.
Bondarenko, O. I., & Sahach, V. F. (2006). [Role of mitochondria in reglulation of endothelial cell hyperpolarization to acetylcholine]. Fiziolohichnyi Zhurnal (Kiev, Ukraine : 1994), 52(5), 6-11.
Bondarenko OI, Sahach VF. [Role of Mitochondria in Reglulation of Endothelial Cell Hyperpolarization to Acetylcholine]. Fiziol Zh. 2006;52(5):6-11. PubMed PMID: 17176833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Role of mitochondria in reglulation of endothelial cell hyperpolarization to acetylcholine]. AU - Bondarenko,O I, AU - Sahach,V F, PY - 2006/12/21/pubmed PY - 2007/1/27/medline PY - 2006/12/21/entrez SP - 6 EP - 11 JF - Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) JO - Fiziol Zh VL - 52 IS - 5 N2 - We investigated the regulation of sustained endothelial hyperpolarization to acetylcholine in the rat aortic endothelial cells by mitochondria. Protonofore CCCP and rotenone, an electron transport chain complex I inhibitor, agents that cause mitochondria depolarization, inhibited the sustained hyperpolarization of endothelial cells. This effect was unlikely to be mediated by the free radicals since hydrogen peroxide was shown to hyperpolarize endothelial cells. It is concluded that mitochondrial Ca2+ uptake is essential in prolongation of endothelial hyperpolarization to acetylcholine. SN - 2522-9028 UR - https://www.unboundmedicine.com/medline/citation/17176833/[Role_of_mitochondria_in_reglulation_of_endothelial_cell_hyperpolarization_to_acetylcholine]_ DB - PRIME DP - Unbound Medicine ER -