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Developmental toxic effects of ethylbenzene or toluene alone and in combination with butyl acetate in rats after inhalation exposure.
J Appl Toxicol. 2007 Jan-Feb; 27(1):32-42.JA

Abstract

First, the developmental toxic potential of n-butyl acetate (BA) was examined in Sprague-Dawley rats following whole body inhalation exposure, 6 h day(-1), from day 6 to 20 of gestation, at concentrations of 0, 500, 1000, 2000 and 3000 ppm. Maternal toxicity was evidenced by significant decreases in body weight gain at 2000 and 3000 ppm, and by reduced food consumption at 1000 ppm and higher concentrations. The effects on prenatal development were limited to a significant decrease in fetal weight at 3000 ppm. Thus, inhaled BA was not a selective developmental toxicant. In the second part of this study, the developmental toxic effects of simultaneous exposures to ethylbenzene (EB) and BA, or to toluene (TOL) and BA were evaluated. Pregnant rats were administered EB (0, 250 or 1000 ppm) and BA (0, 500 or 1500 ppm), or TOL (0, 500 or 1500 ppm) and BA (0, 500, 1500 ppm), separately and in combinations, using a 2 x 2 factorial design. The maternal weight gain was reduced after exposure to 1000 ppm EB, to 1500 ppm BA, or to 1500 ppm TOL, either alone or in binary combinations. A significant reduction of fetal weight was associated with exposure to 1000 ppm EB alone, to either mixtures of EB with BA, or to 1500 ppm TOL alone or combined with BA at either concentration. No embryolethal or teratogenic effects were observed whatever the exposure. There was no evidence of interaction between EB and BA or between TOL and BA in causing maternal or developmental effects.

Authors+Show Affiliations

Institut National de Recherche et de Sécurité, Avenue de Bourgogne, BP No. 27, 54501 Vandoeuvre, France. anne-marie.saillenfait@inrs.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17177173

Citation

Saillenfait, Anne-Marie, et al. "Developmental Toxic Effects of Ethylbenzene or Toluene Alone and in Combination With Butyl Acetate in Rats After Inhalation Exposure." Journal of Applied Toxicology : JAT, vol. 27, no. 1, 2007, pp. 32-42.
Saillenfait AM, Gallissot F, Sabaté JP, et al. Developmental toxic effects of ethylbenzene or toluene alone and in combination with butyl acetate in rats after inhalation exposure. J Appl Toxicol. 2007;27(1):32-42.
Saillenfait, A. M., Gallissot, F., Sabaté, J. P., Bourges-Abella, N., & Muller, S. (2007). Developmental toxic effects of ethylbenzene or toluene alone and in combination with butyl acetate in rats after inhalation exposure. Journal of Applied Toxicology : JAT, 27(1), 32-42.
Saillenfait AM, et al. Developmental Toxic Effects of Ethylbenzene or Toluene Alone and in Combination With Butyl Acetate in Rats After Inhalation Exposure. J Appl Toxicol. 2007 Jan-Feb;27(1):32-42. PubMed PMID: 17177173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Developmental toxic effects of ethylbenzene or toluene alone and in combination with butyl acetate in rats after inhalation exposure. AU - Saillenfait,Anne-Marie, AU - Gallissot,Frédéric, AU - Sabaté,Jean-Philippe, AU - Bourges-Abella,Nathalie, AU - Muller,Samuel, PY - 2006/12/21/pubmed PY - 2007/3/3/medline PY - 2006/12/21/entrez SP - 32 EP - 42 JF - Journal of applied toxicology : JAT JO - J Appl Toxicol VL - 27 IS - 1 N2 - First, the developmental toxic potential of n-butyl acetate (BA) was examined in Sprague-Dawley rats following whole body inhalation exposure, 6 h day(-1), from day 6 to 20 of gestation, at concentrations of 0, 500, 1000, 2000 and 3000 ppm. Maternal toxicity was evidenced by significant decreases in body weight gain at 2000 and 3000 ppm, and by reduced food consumption at 1000 ppm and higher concentrations. The effects on prenatal development were limited to a significant decrease in fetal weight at 3000 ppm. Thus, inhaled BA was not a selective developmental toxicant. In the second part of this study, the developmental toxic effects of simultaneous exposures to ethylbenzene (EB) and BA, or to toluene (TOL) and BA were evaluated. Pregnant rats were administered EB (0, 250 or 1000 ppm) and BA (0, 500 or 1500 ppm), or TOL (0, 500 or 1500 ppm) and BA (0, 500, 1500 ppm), separately and in combinations, using a 2 x 2 factorial design. The maternal weight gain was reduced after exposure to 1000 ppm EB, to 1500 ppm BA, or to 1500 ppm TOL, either alone or in binary combinations. A significant reduction of fetal weight was associated with exposure to 1000 ppm EB alone, to either mixtures of EB with BA, or to 1500 ppm TOL alone or combined with BA at either concentration. No embryolethal or teratogenic effects were observed whatever the exposure. There was no evidence of interaction between EB and BA or between TOL and BA in causing maternal or developmental effects. SN - 0260-437X UR - https://www.unboundmedicine.com/medline/citation/17177173/Developmental_toxic_effects_of_ethylbenzene_or_toluene_alone_and_in_combination_with_butyl_acetate_in_rats_after_inhalation_exposure_ L2 - https://doi.org/10.1002/jat.1181 DB - PRIME DP - Unbound Medicine ER -