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Cytokines and soluble CD14 in breast milk in relation with atopic manifestations in mother and infant (KOALA Study).
Clin Exp Allergy. 2006 Dec; 36(12):1609-15.CE

Abstract

BACKGROUND

Conflicting evidence exists concerning the protective role of breastfeeding in allergy and atopic disease aetiology. Breast milk contains biologically active molecules influencing the innate immune system of newborns.

OBJECTIVE

We aim to assess whether cytokines (TGF-beta1, IL-10 and IL-12) and soluble CD14 (sCD14) in breast milk are influenced by maternal atopic constitution and modify the development of atopic manifestations in infants.

METHODS

Milk samples were collected at 1 month post-partum of 315 lactating mothers participating in the ongoing KOALA Birth Cohort Study. The cytokines and sCD14 were analysed by ELISA in the aqueous fraction. We compared the concentrations of cytokines and sCD14 in breast milk between mothers with and without an allergic history and also with and without allergic sensitization (specific IgE). Associations of cytokines and sCD14 with the development of eczema, wheezing in the first 2 years of life and allergic sensitization of infants at the age of 2 years were analysed by multivariate logistic regression analyses to correct for confounders.

RESULTS

We found higher sCD14 levels in mothers with a positive vs. negative allergic history (7.6 vs. 7.0 microg/mL; P = 0.04) and in mothers who were sensitized vs. non-sensitized (7.8 vs. 7.1 microg/mL; P = 0.03). None of the studied immune factors were associated with infant's atopic outcomes. IL-10 was not detected above the detection limit of 0.2 pg/mL.

CONCLUSION

Taking together the results of the present and previous studies, we conclude that there is no convincing evidence for a relation between TGF-beta1, sCD14, IL-10 or IL-12 in breast milk and atopic manifestations in infants.

Authors+Show Affiliations

Care and Public Health Research Institute (CAPHRI), Department of Epidemiology, Maastricht University, Maastricht, The Netherlands. BEP.Snijders@EPID.unimaas.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17177685

Citation

Snijders, B E P., et al. "Cytokines and Soluble CD14 in Breast Milk in Relation With Atopic Manifestations in Mother and Infant (KOALA Study)." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 36, no. 12, 2006, pp. 1609-15.
Snijders BE, Damoiseaux JG, Penders J, et al. Cytokines and soluble CD14 in breast milk in relation with atopic manifestations in mother and infant (KOALA Study). Clin Exp Allergy. 2006;36(12):1609-15.
Snijders, B. E., Damoiseaux, J. G., Penders, J., Kummeling, I., Stelma, F. F., van Ree, R., van den Brandt, P. A., & Thijs, C. (2006). Cytokines and soluble CD14 in breast milk in relation with atopic manifestations in mother and infant (KOALA Study). Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 36(12), 1609-15.
Snijders BE, et al. Cytokines and Soluble CD14 in Breast Milk in Relation With Atopic Manifestations in Mother and Infant (KOALA Study). Clin Exp Allergy. 2006;36(12):1609-15. PubMed PMID: 17177685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytokines and soluble CD14 in breast milk in relation with atopic manifestations in mother and infant (KOALA Study). AU - Snijders,B E P, AU - Damoiseaux,J G M C, AU - Penders,J, AU - Kummeling,I, AU - Stelma,F F, AU - van Ree,R, AU - van den Brandt,P A, AU - Thijs,C, PY - 2006/12/21/pubmed PY - 2007/7/21/medline PY - 2006/12/21/entrez SP - 1609 EP - 15 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin Exp Allergy VL - 36 IS - 12 N2 - BACKGROUND: Conflicting evidence exists concerning the protective role of breastfeeding in allergy and atopic disease aetiology. Breast milk contains biologically active molecules influencing the innate immune system of newborns. OBJECTIVE: We aim to assess whether cytokines (TGF-beta1, IL-10 and IL-12) and soluble CD14 (sCD14) in breast milk are influenced by maternal atopic constitution and modify the development of atopic manifestations in infants. METHODS: Milk samples were collected at 1 month post-partum of 315 lactating mothers participating in the ongoing KOALA Birth Cohort Study. The cytokines and sCD14 were analysed by ELISA in the aqueous fraction. We compared the concentrations of cytokines and sCD14 in breast milk between mothers with and without an allergic history and also with and without allergic sensitization (specific IgE). Associations of cytokines and sCD14 with the development of eczema, wheezing in the first 2 years of life and allergic sensitization of infants at the age of 2 years were analysed by multivariate logistic regression analyses to correct for confounders. RESULTS: We found higher sCD14 levels in mothers with a positive vs. negative allergic history (7.6 vs. 7.0 microg/mL; P = 0.04) and in mothers who were sensitized vs. non-sensitized (7.8 vs. 7.1 microg/mL; P = 0.03). None of the studied immune factors were associated with infant's atopic outcomes. IL-10 was not detected above the detection limit of 0.2 pg/mL. CONCLUSION: Taking together the results of the present and previous studies, we conclude that there is no convincing evidence for a relation between TGF-beta1, sCD14, IL-10 or IL-12 in breast milk and atopic manifestations in infants. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/17177685/Cytokines_and_soluble_CD14_in_breast_milk_in_relation_with_atopic_manifestations_in_mother_and_infant__KOALA_Study__ L2 - https://doi.org/10.1111/j.1365-2222.2006.02613.x DB - PRIME DP - Unbound Medicine ER -