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Diphenyl diselenide prevents oxidative damage induced by cigarette smoke exposure in lung of rat pups.
Toxicology. 2007 Feb 12; 230(2-3):189-96.T

Abstract

The effect of cigarette smoke exposure on lungs of rat pups was evaluated. Animals were exposed to passive cigarette smoke during 3 weeks and a number of toxicological parameters in lung of pups were examined, such as lipid peroxidation, delta-aminolevulic acid dehydratase (delta-ALA-D) activity, components of the enzymatic antioxidant defenses (superoxide dismutase (SOD) and catalase activities) and non-enzymatic antioxidant defenses (Vitamin C and non-protein thiol (NPSH) levels). Furthermore, a possible protective effect of diphenyl diselenide, (PhSe)(2), was studied. The results demonstrated an increase in lipid peroxidation, an inhibition of delta-ALA-D activity, a reduction of Vitamin C and NPSH levels induced by cigarette smoke exposure, indicating damage in lungs of rat pups. Oral administration of (PhSe)(2) (0.5mg/kg) restored TBARS levels, non-enzymatic antioxidant defenses and activity of delta-ALA-D. These results indicated that exposure to cigarette smoke enhanced oxidative stress, thereby disturbing the tissue defense system. (PhSe)(2) protected against oxidative damage induced by cigarette smoke exposure in lung of rat pups.

Authors+Show Affiliations

Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17178183

Citation

Luchese, Cristiane, et al. "Diphenyl Diselenide Prevents Oxidative Damage Induced By Cigarette Smoke Exposure in Lung of Rat Pups." Toxicology, vol. 230, no. 2-3, 2007, pp. 189-96.
Luchese C, Stangherlin EC, Ardais AP, et al. Diphenyl diselenide prevents oxidative damage induced by cigarette smoke exposure in lung of rat pups. Toxicology. 2007;230(2-3):189-96.
Luchese, C., Stangherlin, E. C., Ardais, A. P., Nogueira, C. W., & Santos, F. W. (2007). Diphenyl diselenide prevents oxidative damage induced by cigarette smoke exposure in lung of rat pups. Toxicology, 230(2-3), 189-96.
Luchese C, et al. Diphenyl Diselenide Prevents Oxidative Damage Induced By Cigarette Smoke Exposure in Lung of Rat Pups. Toxicology. 2007 Feb 12;230(2-3):189-96. PubMed PMID: 17178183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diphenyl diselenide prevents oxidative damage induced by cigarette smoke exposure in lung of rat pups. AU - Luchese,Cristiane, AU - Stangherlin,Eluza C, AU - Ardais,Ana P, AU - Nogueira,Cristina W, AU - Santos,Francielli W, Y1 - 2006/11/19/ PY - 2006/08/18/received PY - 2006/11/08/revised PY - 2006/11/12/accepted PY - 2006/12/21/pubmed PY - 2007/3/16/medline PY - 2006/12/21/entrez SP - 189 EP - 96 JF - Toxicology JO - Toxicology VL - 230 IS - 2-3 N2 - The effect of cigarette smoke exposure on lungs of rat pups was evaluated. Animals were exposed to passive cigarette smoke during 3 weeks and a number of toxicological parameters in lung of pups were examined, such as lipid peroxidation, delta-aminolevulic acid dehydratase (delta-ALA-D) activity, components of the enzymatic antioxidant defenses (superoxide dismutase (SOD) and catalase activities) and non-enzymatic antioxidant defenses (Vitamin C and non-protein thiol (NPSH) levels). Furthermore, a possible protective effect of diphenyl diselenide, (PhSe)(2), was studied. The results demonstrated an increase in lipid peroxidation, an inhibition of delta-ALA-D activity, a reduction of Vitamin C and NPSH levels induced by cigarette smoke exposure, indicating damage in lungs of rat pups. Oral administration of (PhSe)(2) (0.5mg/kg) restored TBARS levels, non-enzymatic antioxidant defenses and activity of delta-ALA-D. These results indicated that exposure to cigarette smoke enhanced oxidative stress, thereby disturbing the tissue defense system. (PhSe)(2) protected against oxidative damage induced by cigarette smoke exposure in lung of rat pups. SN - 0300-483X UR - https://www.unboundmedicine.com/medline/citation/17178183/Diphenyl_diselenide_prevents_oxidative_damage_induced_by_cigarette_smoke_exposure_in_lung_of_rat_pups_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300-483X(06)00693-7 DB - PRIME DP - Unbound Medicine ER -