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Immunomodulatory and anticancer activities of flavonoids extracted from litchi (Litchi chinensis Sonn) pericarp.
Int Immunopharmacol. 2007 Feb; 7(2):162-6.II

Abstract

The litchi pericarp extract was subjected to partition by hexane, ethyl acetate and water. Epicatechin, proanthocyanidin B2 and proanthocyanidin B4 were isolated and purified from the ethyl acetate fraction by reverse-phase high performance liquid chromatography. The immunomodulatory activities of epicatechin, proanthocyanidin B2, proanthocyanidin B4 and the ethyl acetate fraction were examined using proliferation of mouse splenocytes. The results showed all these samples had much higher stimulatory effects on splenocyte proliferation than that of the reference, rutin. Epicatechin and the ethyl acetate fraction showed a significantly (P<0.05) stimulatory effect when the concentration was up to 12.5 micro g/ml. Proanthocyanidin B2 and proanthocyanidin B4 exhibited little lower stimulatory effects than epicatechin and the ethyl acetate fraction. The anti-breast cancer activities of epicatechin, proanthocyanidin B2, proanthocyanidin B4 and the ethyl acetate fraction were also evaluated. Epicatechin and proanthocyanidin B2 had lower cytotoxicities to human breast cancer cell MCF-7 and human embryolic lung fibroblast than paclitaxel.

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Authors+Show Affiliations

Zhao M
College of Light Industry and Food Science, South China University of Technology, Guangzhou, PR China. femmzhao@scut.edu.cn
Yang B
No affiliation info available
Wang J
No affiliation info available
Liu Y
No affiliation info available
Yu L
No affiliation info available
Jiang Y
No affiliation info available

MeSH

AcetatesAnimalsAntineoplastic Agents, PhytogenicCatechinCell Line, TumorCell ProliferationCell SurvivalFemaleFruitHumansLitchiMiceMice, Inbred BALB CPlant ExtractsProanthocyanidinsSpleen

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17178382

Citation

Zhao, Mouming, et al. "Immunomodulatory and Anticancer Activities of Flavonoids Extracted From Litchi (Litchi Chinensis Sonn) Pericarp." International Immunopharmacology, vol. 7, no. 2, 2007, pp. 162-6.
Zhao M, Yang B, Wang J, et al. Immunomodulatory and anticancer activities of flavonoids extracted from litchi (Litchi chinensis Sonn) pericarp. Int Immunopharmacol. 2007;7(2):162-6.
Zhao, M., Yang, B., Wang, J., Liu, Y., Yu, L., & Jiang, Y. (2007). Immunomodulatory and anticancer activities of flavonoids extracted from litchi (Litchi chinensis Sonn) pericarp. International Immunopharmacology, 7(2), 162-6.
Zhao M, et al. Immunomodulatory and Anticancer Activities of Flavonoids Extracted From Litchi (Litchi Chinensis Sonn) Pericarp. Int Immunopharmacol. 2007;7(2):162-6. PubMed PMID: 17178382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunomodulatory and anticancer activities of flavonoids extracted from litchi (Litchi chinensis Sonn) pericarp. AU - Zhao,Mouming, AU - Yang,Bao, AU - Wang,Jinshui, AU - Liu,Yang, AU - Yu,Limei, AU - Jiang,Yueming, Y1 - 2006/10/05/ PY - 2006/07/22/received PY - 2006/08/21/revised PY - 2006/09/08/accepted PY - 2006/12/21/pubmed PY - 2007/3/22/medline PY - 2006/12/21/entrez SP - 162 EP - 6 JF - International immunopharmacology JO - Int Immunopharmacol VL - 7 IS - 2 N2 - The litchi pericarp extract was subjected to partition by hexane, ethyl acetate and water. Epicatechin, proanthocyanidin B2 and proanthocyanidin B4 were isolated and purified from the ethyl acetate fraction by reverse-phase high performance liquid chromatography. The immunomodulatory activities of epicatechin, proanthocyanidin B2, proanthocyanidin B4 and the ethyl acetate fraction were examined using proliferation of mouse splenocytes. The results showed all these samples had much higher stimulatory effects on splenocyte proliferation than that of the reference, rutin. Epicatechin and the ethyl acetate fraction showed a significantly (P<0.05) stimulatory effect when the concentration was up to 12.5 micro g/ml. Proanthocyanidin B2 and proanthocyanidin B4 exhibited little lower stimulatory effects than epicatechin and the ethyl acetate fraction. The anti-breast cancer activities of epicatechin, proanthocyanidin B2, proanthocyanidin B4 and the ethyl acetate fraction were also evaluated. Epicatechin and proanthocyanidin B2 had lower cytotoxicities to human breast cancer cell MCF-7 and human embryolic lung fibroblast than paclitaxel. SN - 1567-5769 UR - https://www.unboundmedicine.com/medline/citation/17178382/Immunomodulatory_and_anticancer_activities_of_flavonoids_extracted_from_litchi__Litchi_chinensis_Sonn__pericarp_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(06)00281-5 DB - PRIME DP - Unbound Medicine ER -