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DRD4 7-repeat polymorphism moderates the association between maternal unresolved loss or trauma and infant disorganization.
Attach Hum Dev. 2006 Dec; 8(4):291-307.AH

Abstract

Previous studies have related attachment disorganization in children to either dopamine D4 receptor polymorphisms or maternal unresolved loss or trauma and frightening or anomalous parenting. In this study it was examined whether the interaction between genetic (DRD4 7-repeat and -521 C/T) and environmental risk factors (maternal unresolved loss/trauma and maternal frightening behavior) was associated with infant disorganization. A moderating role of the DRD4 gene was found. Maternal unresolved loss or trauma was associated with infant disorganization, but only in the presence of the DRD4 7-repeat polymorphism. The increase in risk for disorganization in children with the 7-repeat allele exposed to maternal unresolved loss/trauma compared to children without these combined risks was 18.8 fold. Similar moderating effects were not found for maternal frightening behavior. Our findings indicate that children are differentially susceptible to unresolved loss or trauma dependent on the presence of the 7-repeat DRD4 allele.

Authors+Show Affiliations

Centre for Child and Family Studies, Leiden University, The Netherlands. vanijzen@fsw.leidenuniv.nlNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17178609

Citation

Van Ijzendoorn, Marinus H., and Marian J. Bakermans-Kranenburg. "DRD4 7-repeat Polymorphism Moderates the Association Between Maternal Unresolved Loss or Trauma and Infant Disorganization." Attachment & Human Development, vol. 8, no. 4, 2006, pp. 291-307.
Van Ijzendoorn MH, Bakermans-Kranenburg MJ. DRD4 7-repeat polymorphism moderates the association between maternal unresolved loss or trauma and infant disorganization. Attach Hum Dev. 2006;8(4):291-307.
Van Ijzendoorn, M. H., & Bakermans-Kranenburg, M. J. (2006). DRD4 7-repeat polymorphism moderates the association between maternal unresolved loss or trauma and infant disorganization. Attachment & Human Development, 8(4), 291-307.
Van Ijzendoorn MH, Bakermans-Kranenburg MJ. DRD4 7-repeat Polymorphism Moderates the Association Between Maternal Unresolved Loss or Trauma and Infant Disorganization. Attach Hum Dev. 2006;8(4):291-307. PubMed PMID: 17178609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - DRD4 7-repeat polymorphism moderates the association between maternal unresolved loss or trauma and infant disorganization. AU - Van Ijzendoorn,Marinus H, AU - Bakermans-Kranenburg,Marian J, PY - 2006/12/21/pubmed PY - 2007/3/23/medline PY - 2006/12/21/entrez SP - 291 EP - 307 JF - Attachment & human development JO - Attach Hum Dev VL - 8 IS - 4 N2 - Previous studies have related attachment disorganization in children to either dopamine D4 receptor polymorphisms or maternal unresolved loss or trauma and frightening or anomalous parenting. In this study it was examined whether the interaction between genetic (DRD4 7-repeat and -521 C/T) and environmental risk factors (maternal unresolved loss/trauma and maternal frightening behavior) was associated with infant disorganization. A moderating role of the DRD4 gene was found. Maternal unresolved loss or trauma was associated with infant disorganization, but only in the presence of the DRD4 7-repeat polymorphism. The increase in risk for disorganization in children with the 7-repeat allele exposed to maternal unresolved loss/trauma compared to children without these combined risks was 18.8 fold. Similar moderating effects were not found for maternal frightening behavior. Our findings indicate that children are differentially susceptible to unresolved loss or trauma dependent on the presence of the 7-repeat DRD4 allele. SN - 1461-6734 UR - https://www.unboundmedicine.com/medline/citation/17178609/DRD4_7_repeat_polymorphism_moderates_the_association_between_maternal_unresolved_loss_or_trauma_and_infant_disorganization_ L2 - https://www.tandfonline.com/doi/full/10.1080/14616730601048159 DB - PRIME DP - Unbound Medicine ER -