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Genetic polymorphisms involved in toxicant-metabolizing enzymes and the risk of chronic benzene poisoning in Chinese occupationally exposed populations.
Xenobiotica. 2007 Jan; 37(1):103-12.X

Abstract

Benzene is a recognized haematotoxin and leukaemogen, but its mechanism of action and the role of genetic susceptibility are still unclear. Cytochrome P450 2E1 (CYP2E1) and myeloperoxidase (MPO) are involved in benzene activation; and NAD (P)H:quinine oxidoreductase 1 (NQO1), glutathione S-transferase theta 1 (GSTT1) and glutathione S-transferase mu 1 (GSTM1) participate in benzene detoxification. The common, well-studied single-nucleotide polymorphisms (SNPs) were analysed in these genes drawn from the toxicant-metabolizing pathways. A total of 100 workers with chronic benzene poisoning (CBP) and 90 controls were enrolled in China. There was a 2.82-fold (95% CI = 1.42-5.58) increased risk of CBP in the subjects with the NQO1 609C > T mutation genotype (T/T) compared with those carrying heterozygous (C/T) and wild-type (C/C). The subjects with the GSTT1 null genotype had a 1.91-fold (95% CI = 1.05-3.45) increased risk of CBP compared with those with GSTT1 non-null genotype. There was no association of CYP2E1 and MPO genotype with CBP. A three genes' interaction showed that there was a 20.41-fold (95% CI = 3.79-111.11) increased risk of CBP in subjects with the NQO1 609C > T T/T genotype and with the GSTT1 null genotype and the GSTM1 null genotype compared with those carrying the NQO1 609C > T C/T and C/C genotype, GSTT1 non-null genotype, and GSTM1 non-null genotype. The study provides evidence of an association of a gene-gene interaction with the risk of CBP.

Authors+Show Affiliations

College of Public Health, XinJiang Medical University, Urumqi, China. ychen88@sina.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17178637

Citation

Chen, Y, et al. "Genetic Polymorphisms Involved in Toxicant-metabolizing Enzymes and the Risk of Chronic Benzene Poisoning in Chinese Occupationally Exposed Populations." Xenobiotica; the Fate of Foreign Compounds in Biological Systems, vol. 37, no. 1, 2007, pp. 103-12.
Chen Y, Li G, Yin S, et al. Genetic polymorphisms involved in toxicant-metabolizing enzymes and the risk of chronic benzene poisoning in Chinese occupationally exposed populations. Xenobiotica. 2007;37(1):103-12.
Chen, Y., Li, G., Yin, S., Xu, J., Ji, Z., Xiu, X., Liu, L., & Ma, D. (2007). Genetic polymorphisms involved in toxicant-metabolizing enzymes and the risk of chronic benzene poisoning in Chinese occupationally exposed populations. Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 37(1), 103-12.
Chen Y, et al. Genetic Polymorphisms Involved in Toxicant-metabolizing Enzymes and the Risk of Chronic Benzene Poisoning in Chinese Occupationally Exposed Populations. Xenobiotica. 2007;37(1):103-12. PubMed PMID: 17178637.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic polymorphisms involved in toxicant-metabolizing enzymes and the risk of chronic benzene poisoning in Chinese occupationally exposed populations. AU - Chen,Y, AU - Li,G, AU - Yin,S, AU - Xu,J, AU - Ji,Z, AU - Xiu,X, AU - Liu,L, AU - Ma,D, PY - 2006/12/21/pubmed PY - 2007/5/22/medline PY - 2006/12/21/entrez SP - 103 EP - 12 JF - Xenobiotica; the fate of foreign compounds in biological systems JO - Xenobiotica VL - 37 IS - 1 N2 - Benzene is a recognized haematotoxin and leukaemogen, but its mechanism of action and the role of genetic susceptibility are still unclear. Cytochrome P450 2E1 (CYP2E1) and myeloperoxidase (MPO) are involved in benzene activation; and NAD (P)H:quinine oxidoreductase 1 (NQO1), glutathione S-transferase theta 1 (GSTT1) and glutathione S-transferase mu 1 (GSTM1) participate in benzene detoxification. The common, well-studied single-nucleotide polymorphisms (SNPs) were analysed in these genes drawn from the toxicant-metabolizing pathways. A total of 100 workers with chronic benzene poisoning (CBP) and 90 controls were enrolled in China. There was a 2.82-fold (95% CI = 1.42-5.58) increased risk of CBP in the subjects with the NQO1 609C > T mutation genotype (T/T) compared with those carrying heterozygous (C/T) and wild-type (C/C). The subjects with the GSTT1 null genotype had a 1.91-fold (95% CI = 1.05-3.45) increased risk of CBP compared with those with GSTT1 non-null genotype. There was no association of CYP2E1 and MPO genotype with CBP. A three genes' interaction showed that there was a 20.41-fold (95% CI = 3.79-111.11) increased risk of CBP in subjects with the NQO1 609C > T T/T genotype and with the GSTT1 null genotype and the GSTM1 null genotype compared with those carrying the NQO1 609C > T C/T and C/C genotype, GSTT1 non-null genotype, and GSTM1 non-null genotype. The study provides evidence of an association of a gene-gene interaction with the risk of CBP. SN - 0049-8254 UR - https://www.unboundmedicine.com/medline/citation/17178637/Genetic_polymorphisms_involved_in_toxicant_metabolizing_enzymes_and_the_risk_of_chronic_benzene_poisoning_in_Chinese_occupationally_exposed_populations_ L2 - https://www.tandfonline.com/doi/full/10.1080/00498250601001662 DB - PRIME DP - Unbound Medicine ER -