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Greater fish, fruit, and vegetable intakes are related to lower incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology.

Abstract

BACKGROUND

Little is known about the role of dietary intake in the development of deep vein thrombosis or pulmonary embolus (venous thromboembolism [VTE]). Homocysteine, factor VIII, and von Willebrand factor levels, risk factors for VTE, are influenced by dietary intake. We tested the hypothesis that foods rich in B vitamins and omega-3 fatty acids are negatively associated and meat intake is positively associated with incidence of VTE.

METHODS AND RESULTS

In a prospective study over 12 years, 14,962 middle-aged adults participating in the Atherosclerosis Risk in Communities study were followed up for incident VTE. All hospitalizations were identified, and 196 VTEs were validated by chart review. A food frequency questionnaire assessed dietary intake at baseline and year 6. In separate proportional hazards regression analyses, risk of developing VTE was computed across quintiles of selected nutrients, major food groups, and the Western diet pattern, with adjustment for demographic and lifestyle factors, body mass index, and diabetes. Hazard ratios and 95% confidence intervals of VTE incidence across quintiles of fruit and vegetable intake were 1.0 (reference), 0.73 (0.48 to 1.11), 0.57 (0.37 to 0.90), 0.47 (0.29 to 0.77), and 0.59 (0.36 to 0.99) (P(trend)=0.03). Eating fish 1 or more times per week was associated with 30% to 45% lower incidence of VTE for quintiles 2 to 5 compared with quintile 1, suggestive of a threshold effect. Hazard ratios of VTE across quintiles of red and processed meat intake were 1.0, 1.24 (0.78 to 1.98), 1.21 (0.74 to 1.98), 1.09 (0.64 to 1.87), and 2.01 (1.15 to 3.53) (P(trend)=0.02). Hazard ratios were attenuated only slightly after adjustment for factors VIIc and VIIIc and von Willebrand factor.

CONCLUSIONS

A diet including more plant food and fish and less red and processed meat is associated with a lower incidence of VTE.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 S Second St, Suite 300, Minneapolis, MN 55454, USA. steffen@epi.umn.edu

    , , ,

    Source

    Circulation 115:2 2007 Jan 16 pg 188-95

    MeSH

    Adult
    Animals
    Cohort Studies
    Diet
    Diet Surveys
    Female
    Fishes
    Follow-Up Studies
    Fruit
    Humans
    Incidence
    Longitudinal Studies
    Male
    Middle Aged
    Prospective Studies
    Pulmonary Embolism
    Thromboembolism
    Vegetables
    Venous Thrombosis

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    17179018

    Citation

    Steffen, Lyn M., et al. "Greater Fish, Fruit, and Vegetable Intakes Are Related to Lower Incidence of Venous Thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology." Circulation, vol. 115, no. 2, 2007, pp. 188-95.
    Steffen LM, Folsom AR, Cushman M, et al. Greater fish, fruit, and vegetable intakes are related to lower incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology. Circulation. 2007;115(2):188-95.
    Steffen, L. M., Folsom, A. R., Cushman, M., Jacobs, D. R., & Rosamond, W. D. (2007). Greater fish, fruit, and vegetable intakes are related to lower incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology. Circulation, 115(2), pp. 188-95.
    Steffen LM, et al. Greater Fish, Fruit, and Vegetable Intakes Are Related to Lower Incidence of Venous Thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology. Circulation. 2007 Jan 16;115(2):188-95. PubMed PMID: 17179018.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Greater fish, fruit, and vegetable intakes are related to lower incidence of venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology. AU - Steffen,Lyn M, AU - Folsom,Aaron R, AU - Cushman,Mary, AU - Jacobs,David R,Jr AU - Rosamond,Wayne D, Y1 - 2006/12/18/ PY - 2006/12/21/pubmed PY - 2007/2/6/medline PY - 2006/12/21/entrez SP - 188 EP - 95 JF - Circulation JO - Circulation VL - 115 IS - 2 N2 - BACKGROUND: Little is known about the role of dietary intake in the development of deep vein thrombosis or pulmonary embolus (venous thromboembolism [VTE]). Homocysteine, factor VIII, and von Willebrand factor levels, risk factors for VTE, are influenced by dietary intake. We tested the hypothesis that foods rich in B vitamins and omega-3 fatty acids are negatively associated and meat intake is positively associated with incidence of VTE. METHODS AND RESULTS: In a prospective study over 12 years, 14,962 middle-aged adults participating in the Atherosclerosis Risk in Communities study were followed up for incident VTE. All hospitalizations were identified, and 196 VTEs were validated by chart review. A food frequency questionnaire assessed dietary intake at baseline and year 6. In separate proportional hazards regression analyses, risk of developing VTE was computed across quintiles of selected nutrients, major food groups, and the Western diet pattern, with adjustment for demographic and lifestyle factors, body mass index, and diabetes. Hazard ratios and 95% confidence intervals of VTE incidence across quintiles of fruit and vegetable intake were 1.0 (reference), 0.73 (0.48 to 1.11), 0.57 (0.37 to 0.90), 0.47 (0.29 to 0.77), and 0.59 (0.36 to 0.99) (P(trend)=0.03). Eating fish 1 or more times per week was associated with 30% to 45% lower incidence of VTE for quintiles 2 to 5 compared with quintile 1, suggestive of a threshold effect. Hazard ratios of VTE across quintiles of red and processed meat intake were 1.0, 1.24 (0.78 to 1.98), 1.21 (0.74 to 1.98), 1.09 (0.64 to 1.87), and 2.01 (1.15 to 3.53) (P(trend)=0.02). Hazard ratios were attenuated only slightly after adjustment for factors VIIc and VIIIc and von Willebrand factor. CONCLUSIONS: A diet including more plant food and fish and less red and processed meat is associated with a lower incidence of VTE. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/17179018/Greater_fish_fruit_and_vegetable_intakes_are_related_to_lower_incidence_of_venous_thromboembolism:_the_Longitudinal_Investigation_of_Thromboembolism_Etiology_ L2 - http://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.106.641688?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -