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Helicobacter pylori and oesophageal and gastric cancers in a prospective study in China.
Br J Cancer 2007; 96(1):172-6BJ

Abstract

In a cohort of 29,584 residents of Linxian, China, followed from 1985 to 2001, we conducted a case-cohort study of the magnitude of the association of Helicobacter pylori seropositivity with cancer risk in a random sample of 300 oesophageal squamous cell carcinomas, 600 gastric cardia adenocarcinomas, all 363 diagnosed gastric non-cardia adenocarcinomas, and a random sample of the entire cohort (N=1050). Baseline serum was evaluated for IgG antibodies to whole-cell and CagA H. pylori antigens by enzyme-linked immunosorbent assay. Risks of both gastric cardia and non-cardia cancers were increased in individuals exposed to H. pylori (Hazard ratios (HRs) and 95% confidence intervals=1.64; 1.26-2.14, and 1.60; 1.15-2.21, respectively), whereas risk of oesophageal squamous cell cancer was not affected (1.17; 0.88-1.57). For both cardia and non-cardia cancers, HRs were higher in younger individuals. With longer time between serum collection to cancer diagnosis, associations became stronger for cardia cancers but weaker for non-cardia cancers. CagA positivity did not modify these associations. The associations between H. pylori exposure and gastric cardia and non-cardia adenocarcinoma development were equally strong, in contrast to Western countries, perhaps due to the absence of Barrett's oesophagus and oesophageal adenocarcinomas in Linxian, making all cardia tumours of gastric origin, rather than a mixture of gastric and oesophageal malignancies.

Authors+Show Affiliations

Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 3034, Bethesda, MD 20892-7232, USA. kamangaf@mail.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17179990

Citation

Kamangar, F, et al. "Helicobacter Pylori and Oesophageal and Gastric Cancers in a Prospective Study in China." British Journal of Cancer, vol. 96, no. 1, 2007, pp. 172-6.
Kamangar F, Qiao YL, Blaser MJ, et al. Helicobacter pylori and oesophageal and gastric cancers in a prospective study in China. Br J Cancer. 2007;96(1):172-6.
Kamangar, F., Qiao, Y. L., Blaser, M. J., Sun, X. D., Katki, H., Fan, J. H., ... Dawsey, S. M. (2007). Helicobacter pylori and oesophageal and gastric cancers in a prospective study in China. British Journal of Cancer, 96(1), pp. 172-6.
Kamangar F, et al. Helicobacter Pylori and Oesophageal and Gastric Cancers in a Prospective Study in China. Br J Cancer. 2007 Jan 15;96(1):172-6. PubMed PMID: 17179990.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori and oesophageal and gastric cancers in a prospective study in China. AU - Kamangar,F, AU - Qiao,Y-L, AU - Blaser,M J, AU - Sun,X-D, AU - Katki,H, AU - Fan,J-H, AU - Perez-Perez,G I, AU - Abnet,C C, AU - Zhao,P, AU - Mark,S D, AU - Taylor,P R, AU - Dawsey,S M, Y1 - 2006/12/19/ PY - 2006/12/21/pubmed PY - 2007/2/23/medline PY - 2006/12/21/entrez SP - 172 EP - 6 JF - British journal of cancer JO - Br. J. Cancer VL - 96 IS - 1 N2 - In a cohort of 29,584 residents of Linxian, China, followed from 1985 to 2001, we conducted a case-cohort study of the magnitude of the association of Helicobacter pylori seropositivity with cancer risk in a random sample of 300 oesophageal squamous cell carcinomas, 600 gastric cardia adenocarcinomas, all 363 diagnosed gastric non-cardia adenocarcinomas, and a random sample of the entire cohort (N=1050). Baseline serum was evaluated for IgG antibodies to whole-cell and CagA H. pylori antigens by enzyme-linked immunosorbent assay. Risks of both gastric cardia and non-cardia cancers were increased in individuals exposed to H. pylori (Hazard ratios (HRs) and 95% confidence intervals=1.64; 1.26-2.14, and 1.60; 1.15-2.21, respectively), whereas risk of oesophageal squamous cell cancer was not affected (1.17; 0.88-1.57). For both cardia and non-cardia cancers, HRs were higher in younger individuals. With longer time between serum collection to cancer diagnosis, associations became stronger for cardia cancers but weaker for non-cardia cancers. CagA positivity did not modify these associations. The associations between H. pylori exposure and gastric cardia and non-cardia adenocarcinoma development were equally strong, in contrast to Western countries, perhaps due to the absence of Barrett's oesophagus and oesophageal adenocarcinomas in Linxian, making all cardia tumours of gastric origin, rather than a mixture of gastric and oesophageal malignancies. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/17179990/Helicobacter_pylori_and_oesophageal_and_gastric_cancers_in_a_prospective_study_in_China_ L2 - http://dx.doi.org/10.1038/sj.bjc.6603517 DB - PRIME DP - Unbound Medicine ER -