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Diagnosis of cystic pancreatic lesions by cytologic examination and carcinoembryonic antigen and amylase assays of cyst contents.
Acta Cytol. 1991 Jul-Aug; 35(4):456-63.AC

Abstract

The contents obtained by fine needle aspiration (FNA) from 41 pancreatic cysts in 32 patients were studied cytologically and assayed for amylase and carcinoembryonic antigen (CEA) levels, which have been shown to discriminate pancreatic pseudocysts from mucinous cystic neoplasms and necrotic cystic carcinomas. The results were correlated with the histopathologic findings following surgery or with a clinical and radiologic follow-up of up to two years. The clinical, radiologic and cytologic characteristics did not discriminate pseudocysts from cystic neoplasms. The amylase content of cysts was high in pseudocysts, cystic carcinomas and mucinous cystic neoplasms. The mean CEA content was highest in cystic carcinomas and mucinous cysts and low in pseudocysts. The cytologic diagnosis of mucinous cystic neoplasms and carcinomas had a sensitivity of 54% and a specificity of 91%. The diagnosis of these lesions based on a CEA level greater than 10 ng/ml had a sensitivity of 100% and a specificity of 81%. The adjunctive use of CEA content analysis enhanced the sensitivity of the cytologic diagnosis of mucinous cystic neoplasms and carcinomas to 100%.

Authors+Show Affiliations

Department of Pathology, Bridgeport Hospital, Connecticut 06610.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1718115

Citation

Pinto, M M., and F V. Meriano. "Diagnosis of Cystic Pancreatic Lesions By Cytologic Examination and Carcinoembryonic Antigen and Amylase Assays of Cyst Contents." Acta Cytologica, vol. 35, no. 4, 1991, pp. 456-63.
Pinto MM, Meriano FV. Diagnosis of cystic pancreatic lesions by cytologic examination and carcinoembryonic antigen and amylase assays of cyst contents. Acta Cytol. 1991;35(4):456-63.
Pinto, M. M., & Meriano, F. V. (1991). Diagnosis of cystic pancreatic lesions by cytologic examination and carcinoembryonic antigen and amylase assays of cyst contents. Acta Cytologica, 35(4), 456-63.
Pinto MM, Meriano FV. Diagnosis of Cystic Pancreatic Lesions By Cytologic Examination and Carcinoembryonic Antigen and Amylase Assays of Cyst Contents. Acta Cytol. 1991 Jul-Aug;35(4):456-63. PubMed PMID: 1718115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis of cystic pancreatic lesions by cytologic examination and carcinoembryonic antigen and amylase assays of cyst contents. AU - Pinto,M M, AU - Meriano,F V, PY - 1991/7/1/pubmed PY - 1991/7/1/medline PY - 1991/7/1/entrez SP - 456 EP - 63 JF - Acta cytologica JO - Acta Cytol VL - 35 IS - 4 N2 - The contents obtained by fine needle aspiration (FNA) from 41 pancreatic cysts in 32 patients were studied cytologically and assayed for amylase and carcinoembryonic antigen (CEA) levels, which have been shown to discriminate pancreatic pseudocysts from mucinous cystic neoplasms and necrotic cystic carcinomas. The results were correlated with the histopathologic findings following surgery or with a clinical and radiologic follow-up of up to two years. The clinical, radiologic and cytologic characteristics did not discriminate pseudocysts from cystic neoplasms. The amylase content of cysts was high in pseudocysts, cystic carcinomas and mucinous cystic neoplasms. The mean CEA content was highest in cystic carcinomas and mucinous cysts and low in pseudocysts. The cytologic diagnosis of mucinous cystic neoplasms and carcinomas had a sensitivity of 54% and a specificity of 91%. The diagnosis of these lesions based on a CEA level greater than 10 ng/ml had a sensitivity of 100% and a specificity of 81%. The adjunctive use of CEA content analysis enhanced the sensitivity of the cytologic diagnosis of mucinous cystic neoplasms and carcinomas to 100%. SN - 0001-5547 UR - https://www.unboundmedicine.com/medline/citation/1718115/Diagnosis_of_cystic_pancreatic_lesions_by_cytologic_examination_and_carcinoembryonic_antigen_and_amylase_assays_of_cyst_contents_ DB - PRIME DP - Unbound Medicine ER -