Citation
Callaghan, Paul D., et al. "In Vivo Analysis of Serotonin Clearance in Rat Hippocampus Reveals That Repeated Administration of P-methoxyamphetamine (PMA), but Not 3,4-methylenedioxymethamphetamine (MDMA), Leads to Long-lasting Deficits in Serotonin Transporter Function." Journal of Neurochemistry, vol. 100, no. 3, 2007, pp. 617-27.
Callaghan PD, Owens WA, Javors MA, et al. In vivo analysis of serotonin clearance in rat hippocampus reveals that repeated administration of p-methoxyamphetamine (PMA), but not 3,4-methylenedioxymethamphetamine (MDMA), leads to long-lasting deficits in serotonin transporter function. J Neurochem. 2007;100(3):617-27.
Callaghan, P. D., Owens, W. A., Javors, M. A., Sanchez, T. A., Jones, D. J., Irvine, R. J., & Daws, L. C. (2007). In vivo analysis of serotonin clearance in rat hippocampus reveals that repeated administration of p-methoxyamphetamine (PMA), but not 3,4-methylenedioxymethamphetamine (MDMA), leads to long-lasting deficits in serotonin transporter function. Journal of Neurochemistry, 100(3), 617-27.
Callaghan PD, et al. In Vivo Analysis of Serotonin Clearance in Rat Hippocampus Reveals That Repeated Administration of P-methoxyamphetamine (PMA), but Not 3,4-methylenedioxymethamphetamine (MDMA), Leads to Long-lasting Deficits in Serotonin Transporter Function. J Neurochem. 2007;100(3):617-27. PubMed PMID: 17181558.
TY - JOUR
T1 - In vivo analysis of serotonin clearance in rat hippocampus reveals that repeated administration of p-methoxyamphetamine (PMA), but not 3,4-methylenedioxymethamphetamine (MDMA), leads to long-lasting deficits in serotonin transporter function.
AU - Callaghan,Paul D,
AU - Owens,W Anthony,
AU - Javors,Martin A,
AU - Sanchez,Teresa A,
AU - Jones,David J,
AU - Irvine,Rodney J,
AU - Daws,Lynette C,
Y1 - 2006/12/01/
PY - 2006/12/22/pubmed
PY - 2007/3/21/medline
PY - 2006/12/22/entrez
SP - 617
EP - 27
JF - Journal of neurochemistry
JO - J Neurochem
VL - 100
IS - 3
N2 - p-Methoxyamphetamine (PMA) has been implicated in fatalities as a result of 'ecstasy' (MDMA) overdose worldwide. Like MDMA, acute effects are associated with marked changes in serotonergic neurotransmission, but the long-term effects of PMA are poorly understood. The aim of this study was to determine the effect of repeated PMA administration on in vitro measures of neurodegeneration: serotonin (5-HT) uptake, 5-HT transporter (SERT) density and 5-HT content in the hippocampus, and compare with effects on in vivo 5-HT clearance. Male rats received PMA, MDMA (4 or 15 mg/kg s.c., twice daily) or vehicle for 4 days and 2 weeks later indices of SERT function were measured. [(3)H]5-HT uptake into synaptosomes and [(3)H]cyanoimipramine binding to the SERT were significantly reduced by both PMA and MDMA treatments. 5-HT content was reduced in MDMA-, but not PMA-treatment. In contrast, clearance of locally applied 5-HT measured in vivo by chronoamperometry was only reduced in rats treated with 15 mg/kg PMA. The finding that 5-HT clearance in vivo was unaltered by MDMA treatment suggests that in vitro measures of 5-HT axonal degeneration do not necessarily predict potential compensatory mechanisms that maintain SERT function under basal conditions.
SN - 0022-3042
UR - https://www.unboundmedicine.com/medline/citation/17181558/In_vivo_analysis_of_serotonin_clearance_in_rat_hippocampus_reveals_that_repeated_administration_of_p_methoxyamphetamine__PMA__but_not_34_methylenedioxymethamphetamine__MDMA__leads_to_long_lasting_deficits_in_serotonin_transporter_function_
L2 - https://doi.org/10.1111/j.1471-4159.2006.04247.x
DB - PRIME
DP - Unbound Medicine
ER -