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Prevalence of Helicobacter pylori cagA, iceA and babA2 alleles in Brazilian patients with upper gastrointestinal diseases.
Acta Trop. 2006 Dec; 100(3):232-40.AT

Abstract

Helicobacter pylori is an important human pathogen associated with gastrointestinal diseases such as gastritis, gastric and duodenal ulcer (peptic ulcer disease, PUD), and gastric cancer. A number of pathogenic factors have been described for this bacterium, and some of them have been proposed as markers for the prediction of the clinical outcome. However, with the exception of the cag and vacA status, there is no universal consensus regarding the importance of the other virulence factors. Therefore, the aim of this study was to investigate the status of H. pylori strains regarding the babA and iceA alleles, as well as the cagA genotype, to reveal any association between these genotypes and clinical outcomes in Brazilian patients. The great majority (92.6%) of the strains were typed as iceA1, while 40.4% were found to possess the babA2 allele. The cagA gene was detected in 73.4% of the strains. The iceA2 and cagA genotypes were associated with PUD, while iceA1 was negatively correlated with PUD. However, considering the high percentage of strains typed as iceA1, these associations must be treated with caution. No clinical entity was associated with the babA2 allele. These results suggest that iceA1 is not a good marker for the diseases associated with H. pylori infection in Brazil. Further studies are needed in order to elucidate the relevance of the babA status, because other studies performed in Brazil have associated the babA2 allele with clinical outcomes. These results also indicate the existence of regional differences in the H. pylori genotypes and their association with clinical outcomes.

Authors+Show Affiliations

Laboratório de Genética e Biologia Molecular, Faculdade de Medicina de Marília (FAMEMA), Brazil. lobogatti@yahoo.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17181989

Citation

Gatti, Luciano Lobo, et al. "Prevalence of Helicobacter Pylori cagA, iceA and babA2 Alleles in Brazilian Patients With Upper Gastrointestinal Diseases." Acta Tropica, vol. 100, no. 3, 2006, pp. 232-40.
Gatti LL, Módena JL, Payão SL, et al. Prevalence of Helicobacter pylori cagA, iceA and babA2 alleles in Brazilian patients with upper gastrointestinal diseases. Acta Trop. 2006;100(3):232-40.
Gatti, L. L., Módena, J. L., Payão, S. L., Smith, M. d. e. . A., Fukuhara, Y., Módena, J. L., de Oliveira, R. B., & Brocchi, M. (2006). Prevalence of Helicobacter pylori cagA, iceA and babA2 alleles in Brazilian patients with upper gastrointestinal diseases. Acta Tropica, 100(3), 232-40.
Gatti LL, et al. Prevalence of Helicobacter Pylori cagA, iceA and babA2 Alleles in Brazilian Patients With Upper Gastrointestinal Diseases. Acta Trop. 2006;100(3):232-40. PubMed PMID: 17181989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of Helicobacter pylori cagA, iceA and babA2 alleles in Brazilian patients with upper gastrointestinal diseases. AU - Gatti,Luciano Lobo, AU - Módena,José Luiz Proença, AU - Payão,Spencer Luiz Marques, AU - Smith,Marília de Arruda Cardoso, AU - Fukuhara,Yara, AU - Módena,José Luiz Pimenta, AU - de Oliveira,Ricardo Brandt, AU - Brocchi,Marcelo, Y1 - 2006/12/19/ PY - 2005/09/21/received PY - 2006/08/01/revised PY - 2006/08/22/accepted PY - 2006/12/22/pubmed PY - 2007/6/5/medline PY - 2006/12/22/entrez SP - 232 EP - 40 JF - Acta tropica JO - Acta Trop VL - 100 IS - 3 N2 - Helicobacter pylori is an important human pathogen associated with gastrointestinal diseases such as gastritis, gastric and duodenal ulcer (peptic ulcer disease, PUD), and gastric cancer. A number of pathogenic factors have been described for this bacterium, and some of them have been proposed as markers for the prediction of the clinical outcome. However, with the exception of the cag and vacA status, there is no universal consensus regarding the importance of the other virulence factors. Therefore, the aim of this study was to investigate the status of H. pylori strains regarding the babA and iceA alleles, as well as the cagA genotype, to reveal any association between these genotypes and clinical outcomes in Brazilian patients. The great majority (92.6%) of the strains were typed as iceA1, while 40.4% were found to possess the babA2 allele. The cagA gene was detected in 73.4% of the strains. The iceA2 and cagA genotypes were associated with PUD, while iceA1 was negatively correlated with PUD. However, considering the high percentage of strains typed as iceA1, these associations must be treated with caution. No clinical entity was associated with the babA2 allele. These results suggest that iceA1 is not a good marker for the diseases associated with H. pylori infection in Brazil. Further studies are needed in order to elucidate the relevance of the babA status, because other studies performed in Brazil have associated the babA2 allele with clinical outcomes. These results also indicate the existence of regional differences in the H. pylori genotypes and their association with clinical outcomes. SN - 0001-706X UR - https://www.unboundmedicine.com/medline/citation/17181989/Prevalence_of_Helicobacter_pylori_cagA_iceA_and_babA2_alleles_in_Brazilian_patients_with_upper_gastrointestinal_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0001-706X(06)00217-8 DB - PRIME DP - Unbound Medicine ER -