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Endocrinological markers for assessing hyperandrogenemia in women classified as having polycystic ovary syndrome (PCOS) according to the revised 2003 diagnostic criteria.
Eur J Med Res. 2006 Dec 14; 11(12):540-4.EJ

Abstract

The aim of this study was to investigate whether free testosterone estimated by calculation from total testosterone and sex hormone-binding globulin or free androgen indexes were more appropriate markers for assessing hyperandrogenemia in patients with polycystic ovary syndrome (PCOS). 107 Caucasian women were presented at our Division of Gynecological Endocrinology and Reproductive Medicine because of their infertility and hirsutism. Hirsutism was quantitatively assessed using a modified Ferriman-Gallwey score; oligo-ovulation or/and anovulation were assessed; polycystic ovaries were assessed; afterwards women were classified as having PCOS according to the revised 2003 consensus on diagnostic criteria for PCOS or classified as controls; endocrinological parameters were assessed using commercial immunoassays or were calculated. 50 women were classified as having PCOS; 57 women were classified as controls because they did not fulfill the criteria of PCOS. Calculated free and bioavailable testosterone, FAI, total testosterone, free testosterone assessed by immunoassay and DHEAS were significantly increased in women classified as having PCOS. All endocrinological markers for assessing hyperandrogenemia were elevated in the PCOS group regardless if they were assessed using commercial immunoassays or were calculated. Calculated values showed no diagnostic advantage in this study.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Erlangen University Hospital, Universitätsstr. 21-23, 91054 Erlangen, Germany. andreas.mueller@gyn.imed.uni-erlangen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17182367

Citation

Mueller, Andreas, et al. "Endocrinological Markers for Assessing Hyperandrogenemia in Women Classified as Having Polycystic Ovary Syndrome (PCOS) According to the Revised 2003 Diagnostic Criteria." European Journal of Medical Research, vol. 11, no. 12, 2006, pp. 540-4.
Mueller A, Dittrich R, Binder H, et al. Endocrinological markers for assessing hyperandrogenemia in women classified as having polycystic ovary syndrome (PCOS) according to the revised 2003 diagnostic criteria. Eur J Med Res. 2006;11(12):540-4.
Mueller, A., Dittrich, R., Binder, H., Hoffmann, I., Beckmann, M. W., & Cupisti, S. (2006). Endocrinological markers for assessing hyperandrogenemia in women classified as having polycystic ovary syndrome (PCOS) according to the revised 2003 diagnostic criteria. European Journal of Medical Research, 11(12), 540-4.
Mueller A, et al. Endocrinological Markers for Assessing Hyperandrogenemia in Women Classified as Having Polycystic Ovary Syndrome (PCOS) According to the Revised 2003 Diagnostic Criteria. Eur J Med Res. 2006 Dec 14;11(12):540-4. PubMed PMID: 17182367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocrinological markers for assessing hyperandrogenemia in women classified as having polycystic ovary syndrome (PCOS) according to the revised 2003 diagnostic criteria. AU - Mueller,Andreas, AU - Dittrich,R, AU - Binder,H, AU - Hoffmann,I, AU - Beckmann,M W, AU - Cupisti,S, PY - 2006/12/22/pubmed PY - 2007/7/3/medline PY - 2006/12/22/entrez SP - 540 EP - 4 JF - European journal of medical research JO - Eur J Med Res VL - 11 IS - 12 N2 - The aim of this study was to investigate whether free testosterone estimated by calculation from total testosterone and sex hormone-binding globulin or free androgen indexes were more appropriate markers for assessing hyperandrogenemia in patients with polycystic ovary syndrome (PCOS). 107 Caucasian women were presented at our Division of Gynecological Endocrinology and Reproductive Medicine because of their infertility and hirsutism. Hirsutism was quantitatively assessed using a modified Ferriman-Gallwey score; oligo-ovulation or/and anovulation were assessed; polycystic ovaries were assessed; afterwards women were classified as having PCOS according to the revised 2003 consensus on diagnostic criteria for PCOS or classified as controls; endocrinological parameters were assessed using commercial immunoassays or were calculated. 50 women were classified as having PCOS; 57 women were classified as controls because they did not fulfill the criteria of PCOS. Calculated free and bioavailable testosterone, FAI, total testosterone, free testosterone assessed by immunoassay and DHEAS were significantly increased in women classified as having PCOS. All endocrinological markers for assessing hyperandrogenemia were elevated in the PCOS group regardless if they were assessed using commercial immunoassays or were calculated. Calculated values showed no diagnostic advantage in this study. SN - 0949-2321 UR - https://www.unboundmedicine.com/medline/citation/17182367/Endocrinological_markers_for_assessing_hyperandrogenemia_in_women_classified_as_having_polycystic_ovary_syndrome__PCOS__according_to_the_revised_2003_diagnostic_criteria_ L2 - https://medlineplus.gov/polycysticovarysyndrome.html DB - PRIME DP - Unbound Medicine ER -