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Association of CD4+CD25+Foxp3+ regulatory T cells with chronic activity and viral clearance in patients with hepatitis B.
Int Immunol. 2007 Feb; 19(2):133-40.II

Abstract

Chronic activity of hepatitis B is thought to involve aberrant immune tolerance of unknown mechanism. In this study, we examined the role of CD4(+)CD25(+)Foxp3(+) regulatory T cells in disease activity and viral clearance in hepatitis B. Patients with chronic active hepatitis B (CAH) and asymptomatic HBV carriers (AsC) exhibited a significantly high frequency of CD4(+)CD25(+)Foxp3(+) T cells as opposed to that of controls and resolved HBV infection. These CD4(+)CD25(+) T cells expressed an elevated level of Foxp3 and displayed increased inhibitory activity towards both CD4(+)CD25(-) and CD8(+) effector cells. They were found to accumulate in liver biopsy tissue of CAH patients as opposed to controls. The frequency of CD4(+)CD25(+)Foxp3(+) T cells correlated positively with hepatitis B envelope (HBe) antigen status and serum HBV DNA copy numbers and had a converse relationship with HBe antibody status in patients with CAH and AsC. It was evident that in these patients, the increased frequency of CD4(+)CD25(+)Foxp3(+) T cells was associated with serum levels of transforming growth factor-beta known to promote peripheral conversion of CD4(+)CD25(-) T cells to CD4(+)CD25(+)Foxp3(+) regulatory T cells. The findings provide new insights into the role of CD4(+)CD25(+)Foxp3(+) regulatory T cells in chronic activity and viral clearance in chronic hepatitis B.

Authors+Show Affiliations

Joint Immunology Laboratory, Institute of Health Sciences, Shanghai Jiao-Tong University School of Medicine, Chinese Academy of Sciences, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17182968

Citation

Yang, Guilin, et al. "Association of CD4+CD25+Foxp3+ Regulatory T Cells With Chronic Activity and Viral Clearance in Patients With Hepatitis B." International Immunology, vol. 19, no. 2, 2007, pp. 133-40.
Yang G, Liu A, Xie Q, et al. Association of CD4+CD25+Foxp3+ regulatory T cells with chronic activity and viral clearance in patients with hepatitis B. Int Immunol. 2007;19(2):133-40.
Yang, G., Liu, A., Xie, Q., Guo, T. B., Wan, B., Zhou, B., & Zhang, J. Z. (2007). Association of CD4+CD25+Foxp3+ regulatory T cells with chronic activity and viral clearance in patients with hepatitis B. International Immunology, 19(2), 133-40.
Yang G, et al. Association of CD4+CD25+Foxp3+ Regulatory T Cells With Chronic Activity and Viral Clearance in Patients With Hepatitis B. Int Immunol. 2007;19(2):133-40. PubMed PMID: 17182968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of CD4+CD25+Foxp3+ regulatory T cells with chronic activity and viral clearance in patients with hepatitis B. AU - Yang,Guilin, AU - Liu,Ailian, AU - Xie,Qing, AU - Guo,Taylor B, AU - Wan,Bing, AU - Zhou,Boping, AU - Zhang,Jingwu Z, Y1 - 2006/12/20/ PY - 2006/12/22/pubmed PY - 2007/3/30/medline PY - 2006/12/22/entrez SP - 133 EP - 40 JF - International immunology JO - Int. Immunol. VL - 19 IS - 2 N2 - Chronic activity of hepatitis B is thought to involve aberrant immune tolerance of unknown mechanism. In this study, we examined the role of CD4(+)CD25(+)Foxp3(+) regulatory T cells in disease activity and viral clearance in hepatitis B. Patients with chronic active hepatitis B (CAH) and asymptomatic HBV carriers (AsC) exhibited a significantly high frequency of CD4(+)CD25(+)Foxp3(+) T cells as opposed to that of controls and resolved HBV infection. These CD4(+)CD25(+) T cells expressed an elevated level of Foxp3 and displayed increased inhibitory activity towards both CD4(+)CD25(-) and CD8(+) effector cells. They were found to accumulate in liver biopsy tissue of CAH patients as opposed to controls. The frequency of CD4(+)CD25(+)Foxp3(+) T cells correlated positively with hepatitis B envelope (HBe) antigen status and serum HBV DNA copy numbers and had a converse relationship with HBe antibody status in patients with CAH and AsC. It was evident that in these patients, the increased frequency of CD4(+)CD25(+)Foxp3(+) T cells was associated with serum levels of transforming growth factor-beta known to promote peripheral conversion of CD4(+)CD25(-) T cells to CD4(+)CD25(+)Foxp3(+) regulatory T cells. The findings provide new insights into the role of CD4(+)CD25(+)Foxp3(+) regulatory T cells in chronic activity and viral clearance in chronic hepatitis B. SN - 0953-8178 UR - https://www.unboundmedicine.com/medline/citation/17182968/Association_of_CD4+CD25+Foxp3+_regulatory_T_cells_with_chronic_activity_and_viral_clearance_in_patients_with_hepatitis_B_ L2 - https://academic.oup.com/intimm/article-lookup/doi/10.1093/intimm/dxl130 DB - PRIME DP - Unbound Medicine ER -