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Roles of different subtypes of opioid receptors in mediating the ventrolateral orbital cortex opioid-induced inhibition of mirror-neuropathic pain in the rat.
Neuroscience. 2007 Feb 23; 144(4):1486-94.N

Abstract

Previous studies have demonstrated that opioid receptors in the prefrontal ventrolateral orbital cortex (VLO) are involved in anti-nociception. The aim of this current study was to examine whether opioid receptors in the VLO have effects on the hypersensitivity induced by contralateral L5 and L6 spinal nerve ligation (SNL), termed as mirror neuropathic pain (MNP) in the male rat. Morphine (1.0, 2.5, 5.0 microg) microinjected into the VLO contralateral to the SNL depressed the mechanical paw withdrawal assessed by von Frey filaments and the cold plate (4 degrees C)-induced paw lifting in a dose-dependent manner on the side without SNL. These effects were antagonized by microinjection of the non-selective opioid receptor antagonist naloxone (1.0 mug) into the same VLO site. Microinjection of endomorphin-1 (5.0 microg), a highly selective mu-opioid receptor agonist, and [d-Ala(2), d-Leu(5)]-enkephalin (DADLE, 10 microg), a delta-/mu-receptor agonist, also depressed the MNP. The effects of both drugs were blocked by selective mu-receptor antagonist beta-funaltrexamine (beta-FNA, 3.75 microg), but the effect of the DADLE was not influenced by the selective delta-receptor antagonist naltrindole (5.0 microg). Microinjection of the kappa-opioid receptor agonist spiradoline mesylate salt (U-62066) (100 microg) had no effect on the MNP. These results suggest that the VLO is involved in opioid-induced inhibition of the MNP and the effect is mediated by mu- (but not delta- and kappa-) opioid receptors.

Authors+Show Affiliations

Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University School of Medicine, Yanta Road West 76, Xi'an, Shaanxi 710061, PR China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17184926

Citation

Zhao, M, et al. "Roles of Different Subtypes of Opioid Receptors in Mediating the Ventrolateral Orbital Cortex Opioid-induced Inhibition of Mirror-neuropathic Pain in the Rat." Neuroscience, vol. 144, no. 4, 2007, pp. 1486-94.
Zhao M, Wang JY, Jia H, et al. Roles of different subtypes of opioid receptors in mediating the ventrolateral orbital cortex opioid-induced inhibition of mirror-neuropathic pain in the rat. Neuroscience. 2007;144(4):1486-94.
Zhao, M., Wang, J. Y., Jia, H., & Tang, J. S. (2007). Roles of different subtypes of opioid receptors in mediating the ventrolateral orbital cortex opioid-induced inhibition of mirror-neuropathic pain in the rat. Neuroscience, 144(4), 1486-94.
Zhao M, et al. Roles of Different Subtypes of Opioid Receptors in Mediating the Ventrolateral Orbital Cortex Opioid-induced Inhibition of Mirror-neuropathic Pain in the Rat. Neuroscience. 2007 Feb 23;144(4):1486-94. PubMed PMID: 17184926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Roles of different subtypes of opioid receptors in mediating the ventrolateral orbital cortex opioid-induced inhibition of mirror-neuropathic pain in the rat. AU - Zhao,M, AU - Wang,J Y, AU - Jia,H, AU - Tang,J S, Y1 - 2006/12/19/ PY - 2006/07/20/received PY - 2006/11/07/revised PY - 2006/11/08/accepted PY - 2006/12/23/pubmed PY - 2007/5/22/medline PY - 2006/12/23/entrez SP - 1486 EP - 94 JF - Neuroscience JO - Neuroscience VL - 144 IS - 4 N2 - Previous studies have demonstrated that opioid receptors in the prefrontal ventrolateral orbital cortex (VLO) are involved in anti-nociception. The aim of this current study was to examine whether opioid receptors in the VLO have effects on the hypersensitivity induced by contralateral L5 and L6 spinal nerve ligation (SNL), termed as mirror neuropathic pain (MNP) in the male rat. Morphine (1.0, 2.5, 5.0 microg) microinjected into the VLO contralateral to the SNL depressed the mechanical paw withdrawal assessed by von Frey filaments and the cold plate (4 degrees C)-induced paw lifting in a dose-dependent manner on the side without SNL. These effects were antagonized by microinjection of the non-selective opioid receptor antagonist naloxone (1.0 mug) into the same VLO site. Microinjection of endomorphin-1 (5.0 microg), a highly selective mu-opioid receptor agonist, and [d-Ala(2), d-Leu(5)]-enkephalin (DADLE, 10 microg), a delta-/mu-receptor agonist, also depressed the MNP. The effects of both drugs were blocked by selective mu-receptor antagonist beta-funaltrexamine (beta-FNA, 3.75 microg), but the effect of the DADLE was not influenced by the selective delta-receptor antagonist naltrindole (5.0 microg). Microinjection of the kappa-opioid receptor agonist spiradoline mesylate salt (U-62066) (100 microg) had no effect on the MNP. These results suggest that the VLO is involved in opioid-induced inhibition of the MNP and the effect is mediated by mu- (but not delta- and kappa-) opioid receptors. SN - 0306-4522 UR - https://www.unboundmedicine.com/medline/citation/17184926/Roles_of_different_subtypes_of_opioid_receptors_in_mediating_the_ventrolateral_orbital_cortex_opioid_induced_inhibition_of_mirror_neuropathic_pain_in_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(06)01527-2 DB - PRIME DP - Unbound Medicine ER -