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Modulation of temperature-sensitive TRP channels.
Semin Cell Dev Biol. 2006 Dec; 17(6):638-45.SC

Abstract

Animals sense temperature--either cold or hot--by the direct activation of temperature-sensitive members of the TRP family of ion channels, the thermo-TRPs. To date, six TRP channels--TRPV1-4, TRPM8 and TRPA1--have been reported to be directly activated by heat and to be involved in thermosensation. Temperature sensing can be modulated by phosphorylation of intracellular residues by protein kinases or by insertion of new channels into the cell membrane. In this review we provide a brief overview of the properties of thermo-TRPs, and we summarise signalling pathways involved in their regulation.

Authors+Show Affiliations

Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17185012

Citation

Huang, Jiehong, et al. "Modulation of Temperature-sensitive TRP Channels." Seminars in Cell & Developmental Biology, vol. 17, no. 6, 2006, pp. 638-45.
Huang J, Zhang X, McNaughton PA. Modulation of temperature-sensitive TRP channels. Semin Cell Dev Biol. 2006;17(6):638-45.
Huang, J., Zhang, X., & McNaughton, P. A. (2006). Modulation of temperature-sensitive TRP channels. Seminars in Cell & Developmental Biology, 17(6), 638-45.
Huang J, Zhang X, McNaughton PA. Modulation of Temperature-sensitive TRP Channels. Semin Cell Dev Biol. 2006;17(6):638-45. PubMed PMID: 17185012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of temperature-sensitive TRP channels. AU - Huang,Jiehong, AU - Zhang,Xuming, AU - McNaughton,Peter A, Y1 - 2006/11/11/ PY - 2006/12/23/pubmed PY - 2007/7/10/medline PY - 2006/12/23/entrez SP - 638 EP - 45 JF - Seminars in cell & developmental biology JO - Semin Cell Dev Biol VL - 17 IS - 6 N2 - Animals sense temperature--either cold or hot--by the direct activation of temperature-sensitive members of the TRP family of ion channels, the thermo-TRPs. To date, six TRP channels--TRPV1-4, TRPM8 and TRPA1--have been reported to be directly activated by heat and to be involved in thermosensation. Temperature sensing can be modulated by phosphorylation of intracellular residues by protein kinases or by insertion of new channels into the cell membrane. In this review we provide a brief overview of the properties of thermo-TRPs, and we summarise signalling pathways involved in their regulation. SN - 1084-9521 UR - https://www.unboundmedicine.com/medline/citation/17185012/Modulation_of_temperature_sensitive_TRP_channels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1084-9521(06)00114-5 DB - PRIME DP - Unbound Medicine ER -