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Fonofos exposure and cancer incidence in the agricultural health study.
Environ Health Perspect. 2006 Dec; 114(12):1838-42.EH

Abstract

BACKGROUND

The Agricultural Health Study (AHS) is a prospective cohort study of licensed pesticide applicators from Iowa and North Carolina enrolled 1993-1997 and followed for incident cancer through 2002. A previous investigation in this cohort linked exposure to the organophosphate fonofos with incident prostate cancer in subjects with family history of prostate cancer.

OBJECTIVES

This finding along with findings of associations between organophosphate pesticides and cancer more broadly led to this study of fonofos and risk of any cancers among 45,372 pesticide applicators enrolled in the AHS.

METHODS

Pesticide exposure and other data were collected using self-administered questionnaires. Poisson regression was used to calculate rate ratios (RRs) and 95% confidence intervals (CIs) while controlling for potential confounders.

RESULTS

Relative to the unexposed, leukemia risk was elevated in the highest category of lifetime (RR = 2.24; 95% CI, 0.94-5.34, Ptrend = 0.07) and intensity-weighted exposure-days (RR = 2.67; 95% CI, 1.06-6.70, Ptrend = 0.04), a measure that takes into account factors that modify pesticide exposure. Although prostate cancer risk was unrelated to fonofos use overall, among applicators with a family history of prostate cancer, we observed a significant dose-response trend for lifetime exposure-days (Ptrend = 0.02, RR highest tertile vs. unexposed = 1.77, 95% CI, 1.03-3.05; RRinteraction = 1.28, 95% CI, 1.07-1.54). Intensity-weighted results were similar. No associations were observed with other examined cancer sites.

CONCLUSIONS

Further study is warranted to confirm findings with respect to leukemia and determine whether genetic susceptibility modifies prostate cancer risk from pesticide exposure.

Authors+Show Affiliations

Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

17185272

Citation

Mahajan, Rajeev, et al. "Fonofos Exposure and Cancer Incidence in the Agricultural Health Study." Environmental Health Perspectives, vol. 114, no. 12, 2006, pp. 1838-42.
Mahajan R, Blair A, Lynch CF, et al. Fonofos exposure and cancer incidence in the agricultural health study. Environ Health Perspect. 2006;114(12):1838-42.
Mahajan, R., Blair, A., Lynch, C. F., Schroeder, P., Hoppin, J. A., Sandler, D. P., & Alavanja, M. C. (2006). Fonofos exposure and cancer incidence in the agricultural health study. Environmental Health Perspectives, 114(12), 1838-42.
Mahajan R, et al. Fonofos Exposure and Cancer Incidence in the Agricultural Health Study. Environ Health Perspect. 2006;114(12):1838-42. PubMed PMID: 17185272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fonofos exposure and cancer incidence in the agricultural health study. AU - Mahajan,Rajeev, AU - Blair,Aaron, AU - Lynch,Charles F, AU - Schroeder,Paul, AU - Hoppin,Jane A, AU - Sandler,Dale P, AU - Alavanja,Michael C R, PY - 2006/12/23/pubmed PY - 2007/2/14/medline PY - 2006/12/23/entrez SP - 1838 EP - 42 JF - Environmental health perspectives JO - Environ. Health Perspect. VL - 114 IS - 12 N2 - BACKGROUND: The Agricultural Health Study (AHS) is a prospective cohort study of licensed pesticide applicators from Iowa and North Carolina enrolled 1993-1997 and followed for incident cancer through 2002. A previous investigation in this cohort linked exposure to the organophosphate fonofos with incident prostate cancer in subjects with family history of prostate cancer. OBJECTIVES: This finding along with findings of associations between organophosphate pesticides and cancer more broadly led to this study of fonofos and risk of any cancers among 45,372 pesticide applicators enrolled in the AHS. METHODS: Pesticide exposure and other data were collected using self-administered questionnaires. Poisson regression was used to calculate rate ratios (RRs) and 95% confidence intervals (CIs) while controlling for potential confounders. RESULTS: Relative to the unexposed, leukemia risk was elevated in the highest category of lifetime (RR = 2.24; 95% CI, 0.94-5.34, Ptrend = 0.07) and intensity-weighted exposure-days (RR = 2.67; 95% CI, 1.06-6.70, Ptrend = 0.04), a measure that takes into account factors that modify pesticide exposure. Although prostate cancer risk was unrelated to fonofos use overall, among applicators with a family history of prostate cancer, we observed a significant dose-response trend for lifetime exposure-days (Ptrend = 0.02, RR highest tertile vs. unexposed = 1.77, 95% CI, 1.03-3.05; RRinteraction = 1.28, 95% CI, 1.07-1.54). Intensity-weighted results were similar. No associations were observed with other examined cancer sites. CONCLUSIONS: Further study is warranted to confirm findings with respect to leukemia and determine whether genetic susceptibility modifies prostate cancer risk from pesticide exposure. SN - 0091-6765 UR - https://www.unboundmedicine.com/medline/citation/17185272/Fonofos_exposure_and_cancer_incidence_in_the_agricultural_health_study_ L2 - https://ehp.niehs.nih.gov/doi/full/10.1289/ehp.9301?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -