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Cognitive assessment of children at age 2(1/2) years after maternal fish oil supplementation in pregnancy: a randomised controlled trial.
Arch Dis Child Fetal Neonatal Ed. 2008 Jan; 93(1):F45-50.AD

Abstract

OBJECTIVE

To assess the effects of antenatal omega 3 long-chain polyunsaturated fatty acid (n-3 LC PUFA) on cognitive development in a cohort of children whose mothers received high-dose fish oil in pregnancy.

DESIGN

A double-blind randomised placebo-controlled trial.

SETTING

Perth, Western Australia, Australia.

PATIENTS

98 pregnant women received the supplementation from 20 weeks' gestation until delivery. Their infants (n = 72) were assessed at age 2(1/2) years.

INTERVENTIONS

Fish oil (2.2 g docosahexaenoic acid (DHA) and 1.1 g eicosapentaenoic acid (EPA)/day) or olive oil from 20 weeks' gestation until delivery.

OUTCOME MEASURES

Effects on infant growth and developmental quotients (Griffiths Mental Development Scales), receptive language (Peabody Picture Vocabulary Test) and behaviour (Child Behaviour Checklist).

RESULTS

Children in the fish oil-supplemented group (n = 33) attained a significantly higher score for eye and hand coordination (mean ((SD) score 114 (10.2)) than those in the placebo group (n = 39, mean score 108 (SD 11.3); p = 0.021, adjusted p = 0.008). Eye and hand coordination scores correlated with n-3 PUFA levels in cord blood erythrocytes (EPA: r = 0.320, p = 0.007; DHA: r = 0.308, p = 0.009) and inversely correlated with n-6 PUFA (arachidonic acid 20:4n-6: r = -0.331, p = 0.005). Growth measurements in the two groups were similar at age 2(1/2) years.

CONCLUSION

Maternal fish oil supplementation during pregnancy is safe for the fetus and infant, and may have potentially beneficial effects on the child's eye and hand coordination. Further studies are needed to determine the significance of this finding.

Authors+Show Affiliations

School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17185423

Citation

Dunstan, J A., et al. "Cognitive Assessment of Children at Age 2(1/2) Years After Maternal Fish Oil Supplementation in Pregnancy: a Randomised Controlled Trial." Archives of Disease in Childhood. Fetal and Neonatal Edition, vol. 93, no. 1, 2008, pp. F45-50.
Dunstan JA, Simmer K, Dixon G, et al. Cognitive assessment of children at age 2(1/2) years after maternal fish oil supplementation in pregnancy: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2008;93(1):F45-50.
Dunstan, J. A., Simmer, K., Dixon, G., & Prescott, S. L. (2008). Cognitive assessment of children at age 2(1/2) years after maternal fish oil supplementation in pregnancy: a randomised controlled trial. Archives of Disease in Childhood. Fetal and Neonatal Edition, 93(1), F45-50.
Dunstan JA, et al. Cognitive Assessment of Children at Age 2(1/2) Years After Maternal Fish Oil Supplementation in Pregnancy: a Randomised Controlled Trial. Arch Dis Child Fetal Neonatal Ed. 2008;93(1):F45-50. PubMed PMID: 17185423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive assessment of children at age 2(1/2) years after maternal fish oil supplementation in pregnancy: a randomised controlled trial. AU - Dunstan,J A, AU - Simmer,K, AU - Dixon,G, AU - Prescott,S L, Y1 - 2006/12/21/ PY - 2006/12/23/pubmed PY - 2008/1/18/medline PY - 2006/12/23/entrez SP - F45 EP - 50 JF - Archives of disease in childhood. Fetal and neonatal edition JO - Arch Dis Child Fetal Neonatal Ed VL - 93 IS - 1 N2 - OBJECTIVE: To assess the effects of antenatal omega 3 long-chain polyunsaturated fatty acid (n-3 LC PUFA) on cognitive development in a cohort of children whose mothers received high-dose fish oil in pregnancy. DESIGN: A double-blind randomised placebo-controlled trial. SETTING: Perth, Western Australia, Australia. PATIENTS: 98 pregnant women received the supplementation from 20 weeks' gestation until delivery. Their infants (n = 72) were assessed at age 2(1/2) years. INTERVENTIONS: Fish oil (2.2 g docosahexaenoic acid (DHA) and 1.1 g eicosapentaenoic acid (EPA)/day) or olive oil from 20 weeks' gestation until delivery. OUTCOME MEASURES: Effects on infant growth and developmental quotients (Griffiths Mental Development Scales), receptive language (Peabody Picture Vocabulary Test) and behaviour (Child Behaviour Checklist). RESULTS: Children in the fish oil-supplemented group (n = 33) attained a significantly higher score for eye and hand coordination (mean ((SD) score 114 (10.2)) than those in the placebo group (n = 39, mean score 108 (SD 11.3); p = 0.021, adjusted p = 0.008). Eye and hand coordination scores correlated with n-3 PUFA levels in cord blood erythrocytes (EPA: r = 0.320, p = 0.007; DHA: r = 0.308, p = 0.009) and inversely correlated with n-6 PUFA (arachidonic acid 20:4n-6: r = -0.331, p = 0.005). Growth measurements in the two groups were similar at age 2(1/2) years. CONCLUSION: Maternal fish oil supplementation during pregnancy is safe for the fetus and infant, and may have potentially beneficial effects on the child's eye and hand coordination. Further studies are needed to determine the significance of this finding. SN - 1468-2052 UR - https://www.unboundmedicine.com/medline/citation/17185423/Cognitive_assessment_of_children_at_age_2_1/2__years_after_maternal_fish_oil_supplementation_in_pregnancy:_a_randomised_controlled_trial_ L2 - https://fn.bmj.com/lookup/pmidlookup?view=long&pmid=17185423 DB - PRIME DP - Unbound Medicine ER -