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The genetics of fibromyalgia syndrome.
Pharmacogenomics 2007; 8(1):67-74P

Abstract

Fibromyalgia syndrome (FMS) is a common chronic widespread pain syndrome mainly affecting women. Although the etiology of FMS is not completely understood, varieties of neuroendocrine disturbances, as well as abnormalities of autonomic function, have been implicated in its pathogenesis. The exposure of a genetically predisposed individual to a host of environmental stressors is presumed to lead to the development of FMS. Fibromyalgia overlaps with several related syndromes, collectively compromising the spectrum of the functional somatic disorder. FMS is characterized by a strong familial aggregation. Recent evidence suggests a role for polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems in the etiopathogenesis of FMS. These polymorphisms are not specific for FMS and are similarly associated with additional comorbid conditions. The mode of inheritance in FMS is unknown, but it is most probably polygenic. Recognition of these gene polymorphisms may help to better subgroup FMS patients and to guide a more rational pharmacological approach. Future genetic studies conducted in larger cohorts of FMS patients and matched control groups may further illuminate the role of genetics in FMS.

Authors+Show Affiliations

Ben Gurion University, Department of Medicine H, Soroka Medical Center and Faculty of Health Sciences, Beer Sheva, Israel. dbuskila@bgumail.bgu.ac.ilNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17187510

Citation

Buskila, Dan, et al. "The Genetics of Fibromyalgia Syndrome." Pharmacogenomics, vol. 8, no. 1, 2007, pp. 67-74.
Buskila D, Sarzi-Puttini P, Ablin JN. The genetics of fibromyalgia syndrome. Pharmacogenomics. 2007;8(1):67-74.
Buskila, D., Sarzi-Puttini, P., & Ablin, J. N. (2007). The genetics of fibromyalgia syndrome. Pharmacogenomics, 8(1), pp. 67-74.
Buskila D, Sarzi-Puttini P, Ablin JN. The Genetics of Fibromyalgia Syndrome. Pharmacogenomics. 2007;8(1):67-74. PubMed PMID: 17187510.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The genetics of fibromyalgia syndrome. AU - Buskila,Dan, AU - Sarzi-Puttini,Piercarlo, AU - Ablin,Jacob N, PY - 2006/12/26/pubmed PY - 2007/12/6/medline PY - 2006/12/26/entrez SP - 67 EP - 74 JF - Pharmacogenomics JO - Pharmacogenomics VL - 8 IS - 1 N2 - Fibromyalgia syndrome (FMS) is a common chronic widespread pain syndrome mainly affecting women. Although the etiology of FMS is not completely understood, varieties of neuroendocrine disturbances, as well as abnormalities of autonomic function, have been implicated in its pathogenesis. The exposure of a genetically predisposed individual to a host of environmental stressors is presumed to lead to the development of FMS. Fibromyalgia overlaps with several related syndromes, collectively compromising the spectrum of the functional somatic disorder. FMS is characterized by a strong familial aggregation. Recent evidence suggests a role for polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems in the etiopathogenesis of FMS. These polymorphisms are not specific for FMS and are similarly associated with additional comorbid conditions. The mode of inheritance in FMS is unknown, but it is most probably polygenic. Recognition of these gene polymorphisms may help to better subgroup FMS patients and to guide a more rational pharmacological approach. Future genetic studies conducted in larger cohorts of FMS patients and matched control groups may further illuminate the role of genetics in FMS. SN - 1744-8042 UR - https://www.unboundmedicine.com/medline/citation/17187510/The_genetics_of_fibromyalgia_syndrome_ L2 - http://www.futuremedicine.com/doi/full/10.2217/14622416.8.1.67?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -