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Improvement of the eradication rate of Helicobacter pylori gastritis in children is by adjunction of omeprazole to a dual antibiotherapy.

Abstract

AIM

The possible improvement of efficacy and tolerability of a 7-day dual antibiotherapy amoxicillin-clarithromycin (AC) on the eradication of Helicobacter pylori (H. pylori) gastritis in children by the adjunction of omeprazole (OAC) was studied.

METHODS

Forty-six children presenting with H. pylori gastritis, assessed at inclusion by endoscopy, H. pylori urease test, histology and/or culture were randomised to a twice-daily regimen of AC or OAC. A (13)C-urease breath test was performed 4-6 weeks after the end of the treatment period to evaluate H. pylori eradication.

RESULTS

A larger proportion of patients was H. pylori negative (69%) in the OAC regimen treatment 4-6 weeks after eradication treatment compared with those who received dual AC therapy (15%). A total of seven patients (three in the OAC and four in the AC group) reported adverse events (AEs). Only vomiting was reported in more than one patient (one in each treatment regimen) and only one AE was severe (urticaria: in the OAC group, but considered not related to treatment).

CONCLUSION

A larger eradication rate of H. pylori was obtained in the triple OAC group than in the dual AC group. Both therapy regimens can be safely administered to children for 7 days.

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  • Authors+Show Affiliations

    ,

    Queen Fabiola Children's Hospital, Brussels, Belgium.

    , , , , ,

    Source

    MeSH

    Adolescent
    Amoxicillin
    Anti-Bacterial Agents
    Anti-Ulcer Agents
    Breath Tests
    Child
    Child, Preschool
    Clarithromycin
    Double-Blind Method
    Drug Therapy, Combination
    Female
    Gastritis
    Helicobacter Infections
    Helicobacter pylori
    Humans
    Male
    Omeprazole
    Treatment Outcome
    Urease

    Pub Type(s)

    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17187610

    Citation

    Cadranel, S, et al. "Improvement of the Eradication Rate of Helicobacter Pylori Gastritis in Children Is By Adjunction of Omeprazole to a Dual Antibiotherapy." Acta Paediatrica (Oslo, Norway : 1992), vol. 96, no. 1, 2007, pp. 82-6.
    Cadranel S, Bontemps P, Van Biervliet S, et al. Improvement of the eradication rate of Helicobacter pylori gastritis in children is by adjunction of omeprazole to a dual antibiotherapy. Acta Paediatr. 2007;96(1):82-6.
    Cadranel, S., Bontemps, P., Van Biervliet, S., Alliet, P., Lauvau, D., Vandenhoven, G., & Vandenplas, Y. (2007). Improvement of the eradication rate of Helicobacter pylori gastritis in children is by adjunction of omeprazole to a dual antibiotherapy. Acta Paediatrica (Oslo, Norway : 1992), 96(1), pp. 82-6.
    Cadranel S, et al. Improvement of the Eradication Rate of Helicobacter Pylori Gastritis in Children Is By Adjunction of Omeprazole to a Dual Antibiotherapy. Acta Paediatr. 2007;96(1):82-6. PubMed PMID: 17187610.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Improvement of the eradication rate of Helicobacter pylori gastritis in children is by adjunction of omeprazole to a dual antibiotherapy. AU - Cadranel,S, AU - Bontemps,P, AU - Van Biervliet,S, AU - Alliet,P, AU - Lauvau,D, AU - Vandenhoven,G, AU - Vandenplas,Y, PY - 2006/12/26/pubmed PY - 2007/4/14/medline PY - 2006/12/26/entrez SP - 82 EP - 6 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr. VL - 96 IS - 1 N2 - AIM: The possible improvement of efficacy and tolerability of a 7-day dual antibiotherapy amoxicillin-clarithromycin (AC) on the eradication of Helicobacter pylori (H. pylori) gastritis in children by the adjunction of omeprazole (OAC) was studied. METHODS: Forty-six children presenting with H. pylori gastritis, assessed at inclusion by endoscopy, H. pylori urease test, histology and/or culture were randomised to a twice-daily regimen of AC or OAC. A (13)C-urease breath test was performed 4-6 weeks after the end of the treatment period to evaluate H. pylori eradication. RESULTS: A larger proportion of patients was H. pylori negative (69%) in the OAC regimen treatment 4-6 weeks after eradication treatment compared with those who received dual AC therapy (15%). A total of seven patients (three in the OAC and four in the AC group) reported adverse events (AEs). Only vomiting was reported in more than one patient (one in each treatment regimen) and only one AE was severe (urticaria: in the OAC group, but considered not related to treatment). CONCLUSION: A larger eradication rate of H. pylori was obtained in the triple OAC group than in the dual AC group. Both therapy regimens can be safely administered to children for 7 days. SN - 0803-5253 UR - https://www.unboundmedicine.com/medline/citation/17187610/Improvement_of_the_eradication_rate_of_Helicobacter_pylori_gastritis_in_children_is_by_adjunction_of_omeprazole_to_a_dual_antibiotherapy_ L2 - https://doi.org/10.1111/j.1651-2227.2006.00011.x DB - PRIME DP - Unbound Medicine ER -