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The association between non-alcoholic fatty liver disease and insulin resistance in 20 obese children and adolescents.
Acta Paediatr. 2007 Jan; 96(1):109-12.AP

Abstract

AIM

To investigate whether there are correlations between non-alcoholic fatty liver disease (NAFLD) and insulin resistance in obese children. For the first time, we present clinical data of 20 obese children with NAFLD, including an oral glucose tolerance test.

METHODS

Twenty obese children were diagnosed as having NAFLD by abdominal ultrasonography. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transferase (gamma-GT) were reported. Insulin sensitivity was evaluated by oral glucose tolerance test, oral glucose insulin sensitivity (OGIS) and homeostasis is model assessment (HOMA) index. All parameters were compared to 20 obese age- and sex-matched patients without NAFLD.

RESULTS

With 81% the prevalence of insulin resistance according to HOMA or OGIS criteria was high in the NAFLD-patients compared to the other group with 63%. Statistically significant differences between both groups were found for mean serum ALT levels, mean glucose levels after 30, 60 and 90 minutes and mean insulin levels after 60 minutes of the glucose tolerance test.

CONCLUSION

The high prevalence of insulin resistance we found in children with NAFLD confirms the suggestion that there may be an association between insulin resistance and NAFLD in obese children and indicates that markers of insulin sensitivity could be useful screening parameters for NAFLD.

Authors+Show Affiliations

Division of Nutrition and Metabolism, Department of Paediatrics, Vienna Medical University, Wien, Austria.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17187615

Citation

Ciba, Iris, and Kurt Widhalm. "The Association Between Non-alcoholic Fatty Liver Disease and Insulin Resistance in 20 Obese Children and Adolescents." Acta Paediatrica (Oslo, Norway : 1992), vol. 96, no. 1, 2007, pp. 109-12.
Ciba I, Widhalm K. The association between non-alcoholic fatty liver disease and insulin resistance in 20 obese children and adolescents. Acta Paediatr. 2007;96(1):109-12.
Ciba, I., & Widhalm, K. (2007). The association between non-alcoholic fatty liver disease and insulin resistance in 20 obese children and adolescents. Acta Paediatrica (Oslo, Norway : 1992), 96(1), 109-12.
Ciba I, Widhalm K. The Association Between Non-alcoholic Fatty Liver Disease and Insulin Resistance in 20 Obese Children and Adolescents. Acta Paediatr. 2007;96(1):109-12. PubMed PMID: 17187615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between non-alcoholic fatty liver disease and insulin resistance in 20 obese children and adolescents. AU - Ciba,Iris, AU - Widhalm,Kurt, PY - 2006/12/26/pubmed PY - 2007/4/14/medline PY - 2006/12/26/entrez SP - 109 EP - 12 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr VL - 96 IS - 1 N2 - AIM: To investigate whether there are correlations between non-alcoholic fatty liver disease (NAFLD) and insulin resistance in obese children. For the first time, we present clinical data of 20 obese children with NAFLD, including an oral glucose tolerance test. METHODS: Twenty obese children were diagnosed as having NAFLD by abdominal ultrasonography. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transferase (gamma-GT) were reported. Insulin sensitivity was evaluated by oral glucose tolerance test, oral glucose insulin sensitivity (OGIS) and homeostasis is model assessment (HOMA) index. All parameters were compared to 20 obese age- and sex-matched patients without NAFLD. RESULTS: With 81% the prevalence of insulin resistance according to HOMA or OGIS criteria was high in the NAFLD-patients compared to the other group with 63%. Statistically significant differences between both groups were found for mean serum ALT levels, mean glucose levels after 30, 60 and 90 minutes and mean insulin levels after 60 minutes of the glucose tolerance test. CONCLUSION: The high prevalence of insulin resistance we found in children with NAFLD confirms the suggestion that there may be an association between insulin resistance and NAFLD in obese children and indicates that markers of insulin sensitivity could be useful screening parameters for NAFLD. SN - 0803-5253 UR - https://www.unboundmedicine.com/medline/citation/17187615/The_association_between_non_alcoholic_fatty_liver_disease_and_insulin_resistance_in_20_obese_children_and_adolescents_ L2 - https://doi.org/10.1111/j.1651-2227.2007.00031.x DB - PRIME DP - Unbound Medicine ER -