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Three-dimensional imaging of macular holes with high-speed optical coherence tomography.
Ophthalmology 2007; 114(4):763-73O

Abstract

OBJECTIVE

To demonstrate the advantages of 3-dimensional imaging of macular hole pathology using new-generation high-speed optical coherence tomography (OCT).

DESIGN

Prospective observational case series.

PARTICIPANTS

Twenty-one eyes from 20 consecutive patients diagnosed with a macular hole.

METHODS

A prototype high-speed OCT system was built based on a Fourier-domain OCT (FD OCT) technology for patient examination. The system has achieved sensitivity of approximately 98 decibels, axial resolution of approximately 4.3 mum in tissue, and an acquisition rate of approximately 18,700 axial scans per second. Three-dimensional imaging of macular hole pathology was performed based on a raster scan protocol consisting of 256x256 axial scans. All patients were imaged with 3-dimensional OCT, Stratus OCT, and OCT Ophthalmoscope C7.

MAIN OUTCOME MEASURES

Images of macular hole pathologies obtained by 3-dimensional OCT and standard OCT instruments.

RESULTS

The 3-dimensional OCT imaging successfully generated realistic 3-dimensional images of the vitreofoveal interface and intraretinal microstructures associated with a macular hole. The 3-dimensional overview of the vitreofoveal interface was helpful in gaining an immediate understanding of the dynamic interactions of the vitreous and fovea. Observations of consecutive en face images in combination with conventional longitudinal images and of cross-sectional images in combination with sectioned volume images enabled identification of intraretinal microstructures and their 3-dimensional extension associated with a macular hole, such as subfoveal structural changes after vitreous traction, connection of the flap to intraretinal structures, the external limiting membrane (ELM) and its disruption, and elevated photoreceptor inner and outer segments delineated by the ELM. The appearance of inner-wall images of a macular hole produced by photoreceptor inner and outer segment backreflection varied throughout macular hole stages.

CONCLUSIONS

Three-dimensional imaging of macular holes with high-speed OCT based on FD OCT technology offers 3-dimensional overviews that facilitate understanding of the abnormalities in the vitreofoveal interface. It also provides consecutive orthogonal images that allow much more precise and minute observation of 3-dimensionally extending intraretinal structural changes associated with a macular hole than conventional OCT imaging, especially in the photoreceptor inner and outer segments.

Authors+Show Affiliations

Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto, Japan. hangai@kuhp.kyoto-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17187861

Citation

Hangai, Masanori, et al. "Three-dimensional Imaging of Macular Holes With High-speed Optical Coherence Tomography." Ophthalmology, vol. 114, no. 4, 2007, pp. 763-73.
Hangai M, Ojima Y, Gotoh N, et al. Three-dimensional imaging of macular holes with high-speed optical coherence tomography. Ophthalmology. 2007;114(4):763-73.
Hangai, M., Ojima, Y., Gotoh, N., Inoue, R., Yasuno, Y., Makita, S., ... Yoshimura, N. (2007). Three-dimensional imaging of macular holes with high-speed optical coherence tomography. Ophthalmology, 114(4), pp. 763-73.
Hangai M, et al. Three-dimensional Imaging of Macular Holes With High-speed Optical Coherence Tomography. Ophthalmology. 2007;114(4):763-73. PubMed PMID: 17187861.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three-dimensional imaging of macular holes with high-speed optical coherence tomography. AU - Hangai,Masanori, AU - Ojima,Yumiko, AU - Gotoh,Norimoto, AU - Inoue,Ryo, AU - Yasuno,Yoshiaki, AU - Makita,Shuichi, AU - Yamanari,Masahiro, AU - Yatagai,Toyohiko, AU - Kita,Mihori, AU - Yoshimura,Nagahisa, Y1 - 2006/12/20/ PY - 2006/04/23/received PY - 2006/07/17/revised PY - 2006/07/18/accepted PY - 2006/12/26/pubmed PY - 2007/4/14/medline PY - 2006/12/26/entrez SP - 763 EP - 73 JF - Ophthalmology JO - Ophthalmology VL - 114 IS - 4 N2 - OBJECTIVE: To demonstrate the advantages of 3-dimensional imaging of macular hole pathology using new-generation high-speed optical coherence tomography (OCT). DESIGN: Prospective observational case series. PARTICIPANTS: Twenty-one eyes from 20 consecutive patients diagnosed with a macular hole. METHODS: A prototype high-speed OCT system was built based on a Fourier-domain OCT (FD OCT) technology for patient examination. The system has achieved sensitivity of approximately 98 decibels, axial resolution of approximately 4.3 mum in tissue, and an acquisition rate of approximately 18,700 axial scans per second. Three-dimensional imaging of macular hole pathology was performed based on a raster scan protocol consisting of 256x256 axial scans. All patients were imaged with 3-dimensional OCT, Stratus OCT, and OCT Ophthalmoscope C7. MAIN OUTCOME MEASURES: Images of macular hole pathologies obtained by 3-dimensional OCT and standard OCT instruments. RESULTS: The 3-dimensional OCT imaging successfully generated realistic 3-dimensional images of the vitreofoveal interface and intraretinal microstructures associated with a macular hole. The 3-dimensional overview of the vitreofoveal interface was helpful in gaining an immediate understanding of the dynamic interactions of the vitreous and fovea. Observations of consecutive en face images in combination with conventional longitudinal images and of cross-sectional images in combination with sectioned volume images enabled identification of intraretinal microstructures and their 3-dimensional extension associated with a macular hole, such as subfoveal structural changes after vitreous traction, connection of the flap to intraretinal structures, the external limiting membrane (ELM) and its disruption, and elevated photoreceptor inner and outer segments delineated by the ELM. The appearance of inner-wall images of a macular hole produced by photoreceptor inner and outer segment backreflection varied throughout macular hole stages. CONCLUSIONS: Three-dimensional imaging of macular holes with high-speed OCT based on FD OCT technology offers 3-dimensional overviews that facilitate understanding of the abnormalities in the vitreofoveal interface. It also provides consecutive orthogonal images that allow much more precise and minute observation of 3-dimensionally extending intraretinal structural changes associated with a macular hole than conventional OCT imaging, especially in the photoreceptor inner and outer segments. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/17187861/Three_dimensional_imaging_of_macular_holes_with_high_speed_optical_coherence_tomography_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)01257-7 DB - PRIME DP - Unbound Medicine ER -