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Total ghrelin plasma level in patients with the restrictive type of anorexia nervosa.
Regul Pept. 2007 Apr 05; 140(1-2):43-6.RP

Abstract

Ghrelin is produced mainly in the stomach and is an essential link of the brain-gut axis. Ghrelin stimulates hunger centers in hypothalamus controlling food intake and body mass gain. The aim of the study is to analyze the total ghrelin plasma level in patients suffering from restrictive type of anorexia nervosa (AN-R). According to DSM-IV classification a group of 30 AN-R patients was investigated before and after 3 and 6 months of therapy. Therapy included normocaloric diet and cognitive-behavioral psychotherapy (CBT). The control group consisted of 20 girls without any eating disorders. Before the therapy the total ghrelin plasma level in AN-R patients was significantly higher than in the control group. After 3 and 6 months of treatment the total ghrelin plasma level in AN-R patients was significantly lower than in the control group. In AN-R patients, the total ghrelin plasma level is connected with the pathological feeding behavior.

Authors+Show Affiliations

Department and Clinic of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, ul. Ziolowa 45/47, 40-635 Katowice, Poland. mkozik@centrum-pediatrii.com.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17187877

Citation

Janas-Kozik, Malgorzata, et al. "Total Ghrelin Plasma Level in Patients With the Restrictive Type of Anorexia Nervosa." Regulatory Peptides, vol. 140, no. 1-2, 2007, pp. 43-6.
Janas-Kozik M, Krupka-Matuszczyk I, Malinowska-Kolodziej I, et al. Total ghrelin plasma level in patients with the restrictive type of anorexia nervosa. Regul Pept. 2007;140(1-2):43-6.
Janas-Kozik, M., Krupka-Matuszczyk, I., Malinowska-Kolodziej, I., & Lewin-Kowalik, J. (2007). Total ghrelin plasma level in patients with the restrictive type of anorexia nervosa. Regulatory Peptides, 140(1-2), 43-6.
Janas-Kozik M, et al. Total Ghrelin Plasma Level in Patients With the Restrictive Type of Anorexia Nervosa. Regul Pept. 2007 Apr 5;140(1-2):43-6. PubMed PMID: 17187877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Total ghrelin plasma level in patients with the restrictive type of anorexia nervosa. AU - Janas-Kozik,Malgorzata, AU - Krupka-Matuszczyk,Irena, AU - Malinowska-Kolodziej,Izabela, AU - Lewin-Kowalik,Joanna, Y1 - 2006/12/21/ PY - 2006/04/26/received PY - 2006/11/06/revised PY - 2006/11/10/accepted PY - 2006/12/26/pubmed PY - 2007/5/22/medline PY - 2006/12/26/entrez SP - 43 EP - 6 JF - Regulatory peptides JO - Regul. Pept. VL - 140 IS - 1-2 N2 - Ghrelin is produced mainly in the stomach and is an essential link of the brain-gut axis. Ghrelin stimulates hunger centers in hypothalamus controlling food intake and body mass gain. The aim of the study is to analyze the total ghrelin plasma level in patients suffering from restrictive type of anorexia nervosa (AN-R). According to DSM-IV classification a group of 30 AN-R patients was investigated before and after 3 and 6 months of therapy. Therapy included normocaloric diet and cognitive-behavioral psychotherapy (CBT). The control group consisted of 20 girls without any eating disorders. Before the therapy the total ghrelin plasma level in AN-R patients was significantly higher than in the control group. After 3 and 6 months of treatment the total ghrelin plasma level in AN-R patients was significantly lower than in the control group. In AN-R patients, the total ghrelin plasma level is connected with the pathological feeding behavior. SN - 0167-0115 UR - https://www.unboundmedicine.com/medline/citation/17187877/Total_ghrelin_plasma_level_in_patients_with_the_restrictive_type_of_anorexia_nervosa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-0115(06)00223-0 DB - PRIME DP - Unbound Medicine ER -