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The relations among putative biorisk markers in schizotypal adolescents: minor physical anomalies, movement abnormalities, and salivary cortisol.
Biol Psychiatry. 2007 May 15; 61(10):1179-86.BP

Abstract

BACKGROUND

Evidence suggests that prenatal insult may play a role in the etiology of psychotic disorders. Minor physical anomalies (MPA) are an indicator of abnormal fetal development and are elevated in individuals at genetic and behavioral risk for psychosis. Yet, there has been little empirical research on the relationships between MPAs and other neurobiological risk indicators. We hypothesized that the frequency of MPAs (an external marker of prenatal central nervous system [CNS] disruption) would be associated with two other biomarkers suggestive of disruptions in fetal neurodevelopment: movement abnormalities (an indicator of striatal abnormalities) and heightened cortisol secretion (an indicator of hypothalamic-pituitary-adrenal [HPA]/hippocampal function).

METHODS

Participants with schizotypal personality disorder (SPD; n = 39) and both normal (n = 47) and other personality disorders (n = 28) control subjects were administered structured diagnostic interviews and assessed for MPAs, movement abnormalities, and salivary cortisol.

RESULTS

Schizotypal personality disorder participants showed significantly greater MPAs and movement abnormalities and higher cortisol than both the normal and other personality disorders groups. Hierarchical linear regression analyses revealed that higher rates of MPAs were linked with greater movement abnormalities and salivary cortisol.

CONCLUSIONS

The findings suggest that MPAs serve as a marker of neurodevelopmental abnormalities that affect striatal and hippocampal regions.

Authors+Show Affiliations

Emory University, Department of Psychology, Atlanta, Georgia 30322, USA. vmittal@emory.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17188254

Citation

Mittal, Vijay A., et al. "The Relations Among Putative Biorisk Markers in Schizotypal Adolescents: Minor Physical Anomalies, Movement Abnormalities, and Salivary Cortisol." Biological Psychiatry, vol. 61, no. 10, 2007, pp. 1179-86.
Mittal VA, Dhruv S, Tessner KD, et al. The relations among putative biorisk markers in schizotypal adolescents: minor physical anomalies, movement abnormalities, and salivary cortisol. Biol Psychiatry. 2007;61(10):1179-86.
Mittal, V. A., Dhruv, S., Tessner, K. D., Walder, D. J., & Walker, E. F. (2007). The relations among putative biorisk markers in schizotypal adolescents: minor physical anomalies, movement abnormalities, and salivary cortisol. Biological Psychiatry, 61(10), 1179-86.
Mittal VA, et al. The Relations Among Putative Biorisk Markers in Schizotypal Adolescents: Minor Physical Anomalies, Movement Abnormalities, and Salivary Cortisol. Biol Psychiatry. 2007 May 15;61(10):1179-86. PubMed PMID: 17188254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relations among putative biorisk markers in schizotypal adolescents: minor physical anomalies, movement abnormalities, and salivary cortisol. AU - Mittal,Vijay A, AU - Dhruv,Shivali, AU - Tessner,Kevin D, AU - Walder,Deborah J, AU - Walker,Elaine F, Y1 - 2006/12/22/ PY - 2006/07/31/received PY - 2006/08/30/revised PY - 2006/08/30/accepted PY - 2006/12/26/pubmed PY - 2007/8/2/medline PY - 2006/12/26/entrez SP - 1179 EP - 86 JF - Biological psychiatry JO - Biol Psychiatry VL - 61 IS - 10 N2 - BACKGROUND: Evidence suggests that prenatal insult may play a role in the etiology of psychotic disorders. Minor physical anomalies (MPA) are an indicator of abnormal fetal development and are elevated in individuals at genetic and behavioral risk for psychosis. Yet, there has been little empirical research on the relationships between MPAs and other neurobiological risk indicators. We hypothesized that the frequency of MPAs (an external marker of prenatal central nervous system [CNS] disruption) would be associated with two other biomarkers suggestive of disruptions in fetal neurodevelopment: movement abnormalities (an indicator of striatal abnormalities) and heightened cortisol secretion (an indicator of hypothalamic-pituitary-adrenal [HPA]/hippocampal function). METHODS: Participants with schizotypal personality disorder (SPD; n = 39) and both normal (n = 47) and other personality disorders (n = 28) control subjects were administered structured diagnostic interviews and assessed for MPAs, movement abnormalities, and salivary cortisol. RESULTS: Schizotypal personality disorder participants showed significantly greater MPAs and movement abnormalities and higher cortisol than both the normal and other personality disorders groups. Hierarchical linear regression analyses revealed that higher rates of MPAs were linked with greater movement abnormalities and salivary cortisol. CONCLUSIONS: The findings suggest that MPAs serve as a marker of neurodevelopmental abnormalities that affect striatal and hippocampal regions. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/17188254/The_relations_among_putative_biorisk_markers_in_schizotypal_adolescents:_minor_physical_anomalies_movement_abnormalities_and_salivary_cortisol_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(06)01084-5 DB - PRIME DP - Unbound Medicine ER -