Tags

Type your tag names separated by a space and hit enter

Pesticide exposure on southwestern Taiwanese with MnSOD and NQO1 polymorphisms is associated with increased risk of Parkinson's disease.
Clin Chim Acta. 2007 Mar; 378(1-2):136-41.CC

Abstract

BACKGROUND

Hypothetic mechanism of the individual vulnerability to oxidative stress through metabolism of environmental xenobiotics and genotypic polymorphisms has been considered to promote the development of Parkinson's disease (PD). In this case-control study, we determined the role of manganese-containing superoxide dismutase (MnSOD) and NAD(P)H: quinone oxidoreductase 1 (NQO1) genes in PD risk in a population with high prevalence of pesticide exposure.

METHODS

From southwestern region of Taiwan, we enrolled 153 patients with idiopathic PD and 155 healthy control subjects matched for age, sex and origin. Detailed questionnaires of face-to-face interviews among these subjects were collected. PCR-based restriction fragment length polymorphism (RFLP) assays were used to determine the genotypes of MnSOD (-9 T>C) and NQO1 (609 C>T) genes.

RESULTS

Exposure to pesticides associated with PD was significant among patients with an increased odds ratio (OR) of 1.69 (95%CI, 1.07-2.65), and this association remained significant after adjustment for age, sex, and cigarette smoking (aOR=1.68, 95%CI, 1.03-2.76, P=0.023). Considering genetic factors, there were no significant differences in frequencies of both genotypes of MnSOD and NQO1 polymorphisms between PD patients and the control subjects (P>0.05). However, this difference in genotype distribution was significant among subjects who had been exposed to pesticide, with aOR of 2.49 (95%CI, 1.18-5.26, P=0.0072) for MnSOD C allele and aOR of 2.42 (95%CI, 1.16-4.76, P=0.0089) for NQO1 T allele, respectively. Moreover, among subjects exposed to pesticide, the combined MnSOD/NQO1 variant genotype was significantly associated with a 4.09-fold increased risk of PD (95%CI, 1.34-10.64, P=0.0052).

CONCLUSION

Susceptible variants of MnSOD and NQO1 genes may interact with occupational pesticide exposure to increase PD risk in southwestern Taiwanese.

Authors+Show Affiliations

Department of Neurology, Buddhist Dalin Tzu Chi General Hospital, Chia-Yi, and National Taiwan University Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17188257

Citation

Fong, Chin-Shih, et al. "Pesticide Exposure On Southwestern Taiwanese With MnSOD and NQO1 Polymorphisms Is Associated With Increased Risk of Parkinson's Disease." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 378, no. 1-2, 2007, pp. 136-41.
Fong CS, Wu RM, Shieh JC, et al. Pesticide exposure on southwestern Taiwanese with MnSOD and NQO1 polymorphisms is associated with increased risk of Parkinson's disease. Clin Chim Acta. 2007;378(1-2):136-41.
Fong, C. S., Wu, R. M., Shieh, J. C., Chao, Y. T., Fu, Y. P., Kuao, C. L., & Cheng, C. W. (2007). Pesticide exposure on southwestern Taiwanese with MnSOD and NQO1 polymorphisms is associated with increased risk of Parkinson's disease. Clinica Chimica Acta; International Journal of Clinical Chemistry, 378(1-2), 136-41.
Fong CS, et al. Pesticide Exposure On Southwestern Taiwanese With MnSOD and NQO1 Polymorphisms Is Associated With Increased Risk of Parkinson's Disease. Clin Chim Acta. 2007;378(1-2):136-41. PubMed PMID: 17188257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pesticide exposure on southwestern Taiwanese with MnSOD and NQO1 polymorphisms is associated with increased risk of Parkinson's disease. AU - Fong,Chin-Shih, AU - Wu,Ruey-Meei, AU - Shieh,Jia-Ching, AU - Chao,Ya-Ting, AU - Fu,Yi-Ping, AU - Kuao,Chiz-Liang, AU - Cheng,Chun-Wen, Y1 - 2006/11/17/ PY - 2006/03/31/received PY - 2006/11/05/revised PY - 2006/11/13/accepted PY - 2006/12/26/pubmed PY - 2007/4/18/medline PY - 2006/12/26/entrez SP - 136 EP - 41 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin Chim Acta VL - 378 IS - 1-2 N2 - BACKGROUND: Hypothetic mechanism of the individual vulnerability to oxidative stress through metabolism of environmental xenobiotics and genotypic polymorphisms has been considered to promote the development of Parkinson's disease (PD). In this case-control study, we determined the role of manganese-containing superoxide dismutase (MnSOD) and NAD(P)H: quinone oxidoreductase 1 (NQO1) genes in PD risk in a population with high prevalence of pesticide exposure. METHODS: From southwestern region of Taiwan, we enrolled 153 patients with idiopathic PD and 155 healthy control subjects matched for age, sex and origin. Detailed questionnaires of face-to-face interviews among these subjects were collected. PCR-based restriction fragment length polymorphism (RFLP) assays were used to determine the genotypes of MnSOD (-9 T>C) and NQO1 (609 C>T) genes. RESULTS: Exposure to pesticides associated with PD was significant among patients with an increased odds ratio (OR) of 1.69 (95%CI, 1.07-2.65), and this association remained significant after adjustment for age, sex, and cigarette smoking (aOR=1.68, 95%CI, 1.03-2.76, P=0.023). Considering genetic factors, there were no significant differences in frequencies of both genotypes of MnSOD and NQO1 polymorphisms between PD patients and the control subjects (P>0.05). However, this difference in genotype distribution was significant among subjects who had been exposed to pesticide, with aOR of 2.49 (95%CI, 1.18-5.26, P=0.0072) for MnSOD C allele and aOR of 2.42 (95%CI, 1.16-4.76, P=0.0089) for NQO1 T allele, respectively. Moreover, among subjects exposed to pesticide, the combined MnSOD/NQO1 variant genotype was significantly associated with a 4.09-fold increased risk of PD (95%CI, 1.34-10.64, P=0.0052). CONCLUSION: Susceptible variants of MnSOD and NQO1 genes may interact with occupational pesticide exposure to increase PD risk in southwestern Taiwanese. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/17188257/Pesticide_exposure_on_southwestern_Taiwanese_with_MnSOD_and_NQO1_polymorphisms_is_associated_with_increased_risk_of_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(06)00719-4 DB - PRIME DP - Unbound Medicine ER -