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Fascinating metabolic pools of Pelargonium sidoides and Pelargonium reniforme, traditional and phytomedicinal sources of the herbal medicine Umckaloabo.
Phytomedicine. 2007; 14 Suppl 6:9-17.P

Abstract

The metabolic pools of Pelargonium sidoides DC and Pelargonium reniforme CURT, associated with the origin of the herbal medicine Umckaloabo, exhibit remarkable diversity and complexity. They comprise a variety of phenolic and polyphenolic compounds, a notable wealth of highly oxygenated simple coumarins and a number of miscellaneous uncommon metabolites. Noteworthy, the roots of both species express conspicuously distinct coumarin variations that facilitate their identification. Of the range of coumarins identified the titled species shared the ubiquitous scopoletin and the unique members 6,7,8-trihydroxycoumarin and 8-hydroxy-5,6,7-trimethoxycoumarin merely. Furthermore, the current data on the coumarin profiles suggest the occurrence of coumarin sulphates and coumarin glycosides to be apparently confined to P. sidoides, while the occurrence of conventional proanthocyanidins was a common chemical feature. An unprecedented diterpene, designated as reniformin, was encountered in the roots of P. reniforme, possessing a novel diterpene skeleton linked to a unique p-oxyphenethansulfonic moiety. Coumarins were less abundant in the aerial parts of both species. These were rich in flavonoids and hydrolysable tannins including a unique series of O-galloyl-C-glucosylflavones (P. sidoides and P. reniforme) and novel ellagitannins with a (1)C(4) glucopyranose core in P. reniforme, trivially named pelargoniins, accompanied by the new 4-allyl-2,5-dimethoxyphenol-1-beta-D-glucoside. These Pelargoniums have thus represented an attractive source of fascinating secondary metabolites. A proprietary extract of the roots of P. sidoides, EPs 7630, has been developed from this traditional herbal medicine and introduced into modern phytotherapy in Europe. Structural examination of EPs 7630 constituents showed excellent agreement of the profile with that of P. sidoides.

Authors+Show Affiliations

Institut für Pharmazie, Pharmazeutische Biologie, Freie Universität Berlin, Berlin, Germany. kolpharm@zedat.fu-berlin.de <kolpharm@zedat.fu-berlin.de>

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17188477

Citation

Kolodziej, Herbert. "Fascinating Metabolic Pools of Pelargonium Sidoides and Pelargonium Reniforme, Traditional and Phytomedicinal Sources of the Herbal Medicine Umckaloabo." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 14 Suppl 6, 2007, pp. 9-17.
Kolodziej H. Fascinating metabolic pools of Pelargonium sidoides and Pelargonium reniforme, traditional and phytomedicinal sources of the herbal medicine Umckaloabo. Phytomedicine. 2007;14 Suppl 6:9-17.
Kolodziej, H. (2007). Fascinating metabolic pools of Pelargonium sidoides and Pelargonium reniforme, traditional and phytomedicinal sources of the herbal medicine Umckaloabo. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 14 Suppl 6, 9-17.
Kolodziej H. Fascinating Metabolic Pools of Pelargonium Sidoides and Pelargonium Reniforme, Traditional and Phytomedicinal Sources of the Herbal Medicine Umckaloabo. Phytomedicine. 2007;14 Suppl 6:9-17. PubMed PMID: 17188477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fascinating metabolic pools of Pelargonium sidoides and Pelargonium reniforme, traditional and phytomedicinal sources of the herbal medicine Umckaloabo. A1 - Kolodziej,Herbert, Y1 - 2006/12/22/ PY - 2006/12/26/pubmed PY - 2007/5/16/medline PY - 2006/12/26/entrez SP - 9 EP - 17 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 14 Suppl 6 N2 - The metabolic pools of Pelargonium sidoides DC and Pelargonium reniforme CURT, associated with the origin of the herbal medicine Umckaloabo, exhibit remarkable diversity and complexity. They comprise a variety of phenolic and polyphenolic compounds, a notable wealth of highly oxygenated simple coumarins and a number of miscellaneous uncommon metabolites. Noteworthy, the roots of both species express conspicuously distinct coumarin variations that facilitate their identification. Of the range of coumarins identified the titled species shared the ubiquitous scopoletin and the unique members 6,7,8-trihydroxycoumarin and 8-hydroxy-5,6,7-trimethoxycoumarin merely. Furthermore, the current data on the coumarin profiles suggest the occurrence of coumarin sulphates and coumarin glycosides to be apparently confined to P. sidoides, while the occurrence of conventional proanthocyanidins was a common chemical feature. An unprecedented diterpene, designated as reniformin, was encountered in the roots of P. reniforme, possessing a novel diterpene skeleton linked to a unique p-oxyphenethansulfonic moiety. Coumarins were less abundant in the aerial parts of both species. These were rich in flavonoids and hydrolysable tannins including a unique series of O-galloyl-C-glucosylflavones (P. sidoides and P. reniforme) and novel ellagitannins with a (1)C(4) glucopyranose core in P. reniforme, trivially named pelargoniins, accompanied by the new 4-allyl-2,5-dimethoxyphenol-1-beta-D-glucoside. These Pelargoniums have thus represented an attractive source of fascinating secondary metabolites. A proprietary extract of the roots of P. sidoides, EPs 7630, has been developed from this traditional herbal medicine and introduced into modern phytotherapy in Europe. Structural examination of EPs 7630 constituents showed excellent agreement of the profile with that of P. sidoides. SN - 0944-7113 UR - https://www.unboundmedicine.com/medline/citation/17188477/Fascinating_metabolic_pools_of_Pelargonium_sidoides_and_Pelargonium_reniforme_traditional_and_phytomedicinal_sources_of_the_herbal_medicine_Umckaloabo_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(06)00196-6 DB - PRIME DP - Unbound Medicine ER -