Tags

Type your tag names separated by a space and hit enter

Effect of nitric oxide generators on ischemia-reperfusion injury and histamine release in isolated perfused guinea pig heart.
Int Arch Allergy Appl Immunol. 1991; 94(1-4):257-8.IA

Abstract

In an ischemia-reperfusion model obtained in isolated perfused guinea pig heart by means of a double ligature of the left anterior descending coronary artery, the reperfusion of the ischemic myocardium leads to a release of lactate dehydrogenase and histamine, related to a decrease in the microdensitometry of cardiac mast cells and to a tissue calcium overload. The perfusion of the heart with L-arginine and with nitric oxide donors significantly reduces the release of histamine, the loss of mast cell metachromasia and calcium overload. These effects were potentiated by superoxide dismutase.

Authors+Show Affiliations

Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1718888

Citation

Masini, E, et al. "Effect of Nitric Oxide Generators On Ischemia-reperfusion Injury and Histamine Release in Isolated Perfused Guinea Pig Heart." International Archives of Allergy and Applied Immunology, vol. 94, no. 1-4, 1991, pp. 257-8.
Masini E, Gambassi F, Bianchi S, et al. Effect of nitric oxide generators on ischemia-reperfusion injury and histamine release in isolated perfused guinea pig heart. Int Arch Allergy Appl Immunol. 1991;94(1-4):257-8.
Masini, E., Gambassi, F., Bianchi, S., Mugnai, L., Lupini, M., Pistelli, A., & Mannaioni, P. F. (1991). Effect of nitric oxide generators on ischemia-reperfusion injury and histamine release in isolated perfused guinea pig heart. International Archives of Allergy and Applied Immunology, 94(1-4), 257-8.
Masini E, et al. Effect of Nitric Oxide Generators On Ischemia-reperfusion Injury and Histamine Release in Isolated Perfused Guinea Pig Heart. Int Arch Allergy Appl Immunol. 1991;94(1-4):257-8. PubMed PMID: 1718888.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of nitric oxide generators on ischemia-reperfusion injury and histamine release in isolated perfused guinea pig heart. AU - Masini,E, AU - Gambassi,F, AU - Bianchi,S, AU - Mugnai,L, AU - Lupini,M, AU - Pistelli,A, AU - Mannaioni,P F, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 257 EP - 8 JF - International archives of allergy and applied immunology JO - Int. Arch. Allergy Appl. Immunol. VL - 94 IS - 1-4 N2 - In an ischemia-reperfusion model obtained in isolated perfused guinea pig heart by means of a double ligature of the left anterior descending coronary artery, the reperfusion of the ischemic myocardium leads to a release of lactate dehydrogenase and histamine, related to a decrease in the microdensitometry of cardiac mast cells and to a tissue calcium overload. The perfusion of the heart with L-arginine and with nitric oxide donors significantly reduces the release of histamine, the loss of mast cell metachromasia and calcium overload. These effects were potentiated by superoxide dismutase. SN - 0020-5915 UR - https://www.unboundmedicine.com/medline/citation/1718888/Effect_of_nitric_oxide_generators_on_ischemia_reperfusion_injury_and_histamine_release_in_isolated_perfused_guinea_pig_heart_ L2 - https://www.lens.org/lens/search?q=citation_id:1718888 DB - PRIME DP - Unbound Medicine ER -