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Antioxidant supplementation lowers exercise-induced oxidative stress in young overweight adults.
Obesity (Silver Spring). 2006 Dec; 14(12):2224-35.O

Abstract

OBJECTIVE

To determine whether antioxidant (AOX) supplementation attenuates post-exercise oxidative stress and contributors to oxidative stress (inflammation, blood lipids) in overweight young adults.

RESEARCH METHODS AND PROCEDURES

This was a randomized, double-blind, controlled study. Overweight (BMI, 33.2 +/- 1.9 kg/m(2)) and comparative normal-weight (BMI, 21.9 +/- 0.5 kg/m(2)) adults 18 to 30 years old (total N = 48) were enrolled. Participants received either daily antioxidant (AOX) treatment (800 IU of vitamin E, 500 mg of vitamin C, 10 mg of beta-carotene) or placebo (PL) for 8 weeks for a total of four groups. All participants completed a standardized 30-minute cycle exercise bout at baseline and 8 weeks. Exercise-induced changes in lipid hydroperoxide (DeltaPEROX), C-reactive protein (DeltaCRP), interleukin-6 (DeltaIL-6), cholesterol subfractions, triglycerides, total AOX status (DeltaTAS), and adiponectin were assessed.

RESULTS

Exercise-induced DeltaPEROX was lower in the overweight-AOX group (0.09 nM/kg per min) compared with PL-treated overweight and normal-weight groups (0.98, 0.53 nM/kg per min) by 8 weeks (p < 0.05). Adiponectin was increased in both overweight and normal-weight AOX groups (22.1% vs. 3.1%; p < 0.05) but reduced in PL groups. DeltaIL-6, Deltatotal cholesterol, and Deltalow-density lipoprotein-cholesterol concentrations during exercise were lower in the AOX-treated groups compared with PL groups (all p < 0.05). After controlling for BMI, the Deltatotal cholesterol, Deltalow-density lipoprotein-cholesterol, Deltaadiponectin, and DeltaTAS explained 59.1% of the variance of the regression model of the DeltaPEROX by 8 weeks (total model R(2) = 0.600; p = 0.015).

DISCUSSION

AOX lowers exercise-induced oxidative stress in overweight adults. Inflammatory and lipid markers may also be attenuated with AOX. Further studies are needed to determine whether AOX may be used in cardiovascular disease prevention in the overweight population.

Authors+Show Affiliations

Center for the Study of Complementary and Alternative Therapies, University of Virginia Health System, Charlottesville, VA 22908-0905, USA. hvincent@adelphia.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17189550

Citation

Vincent, Heather K., et al. "Antioxidant Supplementation Lowers Exercise-induced Oxidative Stress in Young Overweight Adults." Obesity (Silver Spring, Md.), vol. 14, no. 12, 2006, pp. 2224-35.
Vincent HK, Bourguignon CM, Vincent KR, et al. Antioxidant supplementation lowers exercise-induced oxidative stress in young overweight adults. Obesity (Silver Spring). 2006;14(12):2224-35.
Vincent, H. K., Bourguignon, C. M., Vincent, K. R., Weltman, A. L., Bryant, M., & Taylor, A. G. (2006). Antioxidant supplementation lowers exercise-induced oxidative stress in young overweight adults. Obesity (Silver Spring, Md.), 14(12), 2224-35.
Vincent HK, et al. Antioxidant Supplementation Lowers Exercise-induced Oxidative Stress in Young Overweight Adults. Obesity (Silver Spring). 2006;14(12):2224-35. PubMed PMID: 17189550.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant supplementation lowers exercise-induced oxidative stress in young overweight adults. AU - Vincent,Heather K, AU - Bourguignon,Cheryl M, AU - Vincent,Kevin R, AU - Weltman,Arthur L, AU - Bryant,Mary, AU - Taylor,Ann G, PY - 2006/12/26/pubmed PY - 2007/2/21/medline PY - 2006/12/26/entrez SP - 2224 EP - 35 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 14 IS - 12 N2 - OBJECTIVE: To determine whether antioxidant (AOX) supplementation attenuates post-exercise oxidative stress and contributors to oxidative stress (inflammation, blood lipids) in overweight young adults. RESEARCH METHODS AND PROCEDURES: This was a randomized, double-blind, controlled study. Overweight (BMI, 33.2 +/- 1.9 kg/m(2)) and comparative normal-weight (BMI, 21.9 +/- 0.5 kg/m(2)) adults 18 to 30 years old (total N = 48) were enrolled. Participants received either daily antioxidant (AOX) treatment (800 IU of vitamin E, 500 mg of vitamin C, 10 mg of beta-carotene) or placebo (PL) for 8 weeks for a total of four groups. All participants completed a standardized 30-minute cycle exercise bout at baseline and 8 weeks. Exercise-induced changes in lipid hydroperoxide (DeltaPEROX), C-reactive protein (DeltaCRP), interleukin-6 (DeltaIL-6), cholesterol subfractions, triglycerides, total AOX status (DeltaTAS), and adiponectin were assessed. RESULTS: Exercise-induced DeltaPEROX was lower in the overweight-AOX group (0.09 nM/kg per min) compared with PL-treated overweight and normal-weight groups (0.98, 0.53 nM/kg per min) by 8 weeks (p < 0.05). Adiponectin was increased in both overweight and normal-weight AOX groups (22.1% vs. 3.1%; p < 0.05) but reduced in PL groups. DeltaIL-6, Deltatotal cholesterol, and Deltalow-density lipoprotein-cholesterol concentrations during exercise were lower in the AOX-treated groups compared with PL groups (all p < 0.05). After controlling for BMI, the Deltatotal cholesterol, Deltalow-density lipoprotein-cholesterol, Deltaadiponectin, and DeltaTAS explained 59.1% of the variance of the regression model of the DeltaPEROX by 8 weeks (total model R(2) = 0.600; p = 0.015). DISCUSSION: AOX lowers exercise-induced oxidative stress in overweight adults. Inflammatory and lipid markers may also be attenuated with AOX. Further studies are needed to determine whether AOX may be used in cardiovascular disease prevention in the overweight population. SN - 1930-7381 UR - https://www.unboundmedicine.com/medline/citation/17189550/Antioxidant_supplementation_lowers_exercise_induced_oxidative_stress_in_young_overweight_adults_ L2 - https://doi.org/10.1038/oby.2006.261 DB - PRIME DP - Unbound Medicine ER -