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The level of 2-h post-challenge glucose is an independent risk factor of carotid intima-media thickness progression in Korean type 2 diabetic patients.
J Diabetes Complications. 2007 Jan-Feb; 21(1):7-12.JD

Abstract

OBJECTIVE

To evaluate the relationship between the metabolic abnormalities commonly associated with diabetes and the changes in carotid intima-media thickness (IMT) in Korean type 2 diabetic patients who do not have clinically manifest cardiovascular disease (CVD).

DESIGN

In a prospective study, a total of 152 type 2 diabetic patients were recruited from a group of outpatients at the Yonsei University Hospital.

MATERIALS AND METHODS

The carotid IMTs of 152 subjects with type 2 diabetes (mean age 63.5+/-7.0 years) were determined at baseline and after a mean follow-up time of 23.7+/-3.7 months. Fasting plasma glucose, serum total cholesterol (TC), serum triglyceride, high-density lipoprotein cholesterol (HDL-C), HbA1c, oral glucose tolerance test (OGTT) results for 2-h post-challenge glucose (2hPG), and blood pressure measurements were collected every 3 months and averaged.

RESULTS

The highest quartiles of baseline C-peptide and homeostatic model assessment (HOMA) index showed more IMT progression than the lowest quartiles. The change in the mean IMT correlated with average values of HbA1c (r=.219, P=.007), the 2-h post-challenge glucose (r=.239, P=.003), HDL-C (r=-.228, P=.005), LDL-C (r=.175, P=.033), and non-HDL-C (r=.194, P=.016). Multiple regression analysis demonstrated that the independent risk factor for the mean IMT change in diabetic patients was the average 2hPG level (P=.004). The change in the mean IMT of those in the lowest quartile of average 2hPG (<11.1 mmol/l) was 823+/-176 to 841+/-146 microm (P=.276). In the highest quartile (2hPG >15.3 mmol/l), however, the mean IMT increased from 794+/-127 to 882+/-153 microm (P<.001).

CONCLUSION

The 2hPG parameter among the various metabolic parameters exerts the greatest influence upon the prevention of carotid IMT progression in type 2 diabetic subjects. The level of 2hPG is an independent risk factor for the progression of carotid IMT in Korean type 2 diabetic patients.

Authors+Show Affiliations

Division of Endocrinology, Department of Internal Medicine, Kwandong University College of Medicine, Myongji Hospital, Koyang, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17189868

Citation

Kim, Hyeong-Jin, et al. "The Level of 2-h Post-challenge Glucose Is an Independent Risk Factor of Carotid Intima-media Thickness Progression in Korean Type 2 Diabetic Patients." Journal of Diabetes and Its Complications, vol. 21, no. 1, 2007, pp. 7-12.
Kim HJ, Ahn CW, Kang ES, et al. The level of 2-h post-challenge glucose is an independent risk factor of carotid intima-media thickness progression in Korean type 2 diabetic patients. J Diabetes Complicat. 2007;21(1):7-12.
Kim, H. J., Ahn, C. W., Kang, E. S., Myoung, S. M., Cha, B. S., Won, Y. J., Lim, S. K., Kim, K. R., Huh, K. B., & Lee, H. C. (2007). The level of 2-h post-challenge glucose is an independent risk factor of carotid intima-media thickness progression in Korean type 2 diabetic patients. Journal of Diabetes and Its Complications, 21(1), 7-12.
Kim HJ, et al. The Level of 2-h Post-challenge Glucose Is an Independent Risk Factor of Carotid Intima-media Thickness Progression in Korean Type 2 Diabetic Patients. J Diabetes Complicat. 2007 Jan-Feb;21(1):7-12. PubMed PMID: 17189868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The level of 2-h post-challenge glucose is an independent risk factor of carotid intima-media thickness progression in Korean type 2 diabetic patients. AU - Kim,Hyeong-Jin, AU - Ahn,Chul-Woo, AU - Kang,Eun-Seok, AU - Myoung,Sung-Min, AU - Cha,Bong-Soo, AU - Won,Young-Jun, AU - Lim,Sung-Kil, AU - Kim,Kyung-Rae, AU - Huh,Kap-Bum, AU - Lee,Hyun-Chul, PY - 2005/05/19/received PY - 2005/07/15/revised PY - 2005/11/08/accepted PY - 2006/12/27/pubmed PY - 2007/3/7/medline PY - 2006/12/27/entrez SP - 7 EP - 12 JF - Journal of diabetes and its complications JO - J. Diabetes Complicat. VL - 21 IS - 1 N2 - OBJECTIVE: To evaluate the relationship between the metabolic abnormalities commonly associated with diabetes and the changes in carotid intima-media thickness (IMT) in Korean type 2 diabetic patients who do not have clinically manifest cardiovascular disease (CVD). DESIGN: In a prospective study, a total of 152 type 2 diabetic patients were recruited from a group of outpatients at the Yonsei University Hospital. MATERIALS AND METHODS: The carotid IMTs of 152 subjects with type 2 diabetes (mean age 63.5+/-7.0 years) were determined at baseline and after a mean follow-up time of 23.7+/-3.7 months. Fasting plasma glucose, serum total cholesterol (TC), serum triglyceride, high-density lipoprotein cholesterol (HDL-C), HbA1c, oral glucose tolerance test (OGTT) results for 2-h post-challenge glucose (2hPG), and blood pressure measurements were collected every 3 months and averaged. RESULTS: The highest quartiles of baseline C-peptide and homeostatic model assessment (HOMA) index showed more IMT progression than the lowest quartiles. The change in the mean IMT correlated with average values of HbA1c (r=.219, P=.007), the 2-h post-challenge glucose (r=.239, P=.003), HDL-C (r=-.228, P=.005), LDL-C (r=.175, P=.033), and non-HDL-C (r=.194, P=.016). Multiple regression analysis demonstrated that the independent risk factor for the mean IMT change in diabetic patients was the average 2hPG level (P=.004). The change in the mean IMT of those in the lowest quartile of average 2hPG (<11.1 mmol/l) was 823+/-176 to 841+/-146 microm (P=.276). In the highest quartile (2hPG >15.3 mmol/l), however, the mean IMT increased from 794+/-127 to 882+/-153 microm (P<.001). CONCLUSION: The 2hPG parameter among the various metabolic parameters exerts the greatest influence upon the prevention of carotid IMT progression in type 2 diabetic subjects. The level of 2hPG is an independent risk factor for the progression of carotid IMT in Korean type 2 diabetic patients. SN - 1056-8727 UR - https://www.unboundmedicine.com/medline/citation/17189868/The_level_of_2_h_post_challenge_glucose_is_an_independent_risk_factor_of_carotid_intima_media_thickness_progression_in_Korean_type_2_diabetic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1056-8727(05)00154-6 DB - PRIME DP - Unbound Medicine ER -