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Zinagrandinolides A-C, cytotoxic delta-elemanolide-type sesquiterpene lactones from Zinnia grandiflora.
J Nat Prod. 2006 Dec; 69(12):1820-2.JN

Abstract

Three new delta-elemanolide-type sesquiterpene lactones, zinagrandinolides A-C (1-3), and the known delta-elemanolide 4 have been isolated by a bioassay-guided fractionation of a cytotoxic hexane extract of the aerial parts of Zinnia grandiflora. The structures of 1-3 were determined on the basis of high-resolution mass and NMR data. All compounds exhibited strong cytotoxicity against the cancer cell lines NCI-H460, MCF-7, SF-268, and MIA Pa Ca-2 and the normal human fibroblast cell type WI-38, but none showed significant selectivity.

Authors+Show Affiliations

Bashyal BP
SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 E. Valencia Road, Tucson, AZ 85706-6800, USA.
McLaughlin SP
No affiliation info available
Gunatilaka AA
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicArizonaAsteraceaeCells, CulturedDrug Screening Assays, AntitumorHumansLactonesMolecular StructurePlants, MedicinalSesquiterpenesStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17190470

Citation

Bashyal, Bharat P., et al. "Zinagrandinolides A-C, Cytotoxic Delta-elemanolide-type Sesquiterpene Lactones From Zinnia Grandiflora." Journal of Natural Products, vol. 69, no. 12, 2006, pp. 1820-2.
Bashyal BP, McLaughlin SP, Gunatilaka AA. Zinagrandinolides A-C, cytotoxic delta-elemanolide-type sesquiterpene lactones from Zinnia grandiflora. J Nat Prod. 2006;69(12):1820-2.
Bashyal, B. P., McLaughlin, S. P., & Gunatilaka, A. A. (2006). Zinagrandinolides A-C, cytotoxic delta-elemanolide-type sesquiterpene lactones from Zinnia grandiflora. Journal of Natural Products, 69(12), 1820-2.
Bashyal BP, McLaughlin SP, Gunatilaka AA. Zinagrandinolides A-C, Cytotoxic Delta-elemanolide-type Sesquiterpene Lactones From Zinnia Grandiflora. J Nat Prod. 2006;69(12):1820-2. PubMed PMID: 17190470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zinagrandinolides A-C, cytotoxic delta-elemanolide-type sesquiterpene lactones from Zinnia grandiflora. AU - Bashyal,Bharat P, AU - McLaughlin,Steven P, AU - Gunatilaka,A A Leslie, PY - 2006/12/28/pubmed PY - 2007/2/1/medline PY - 2006/12/28/entrez SP - 1820 EP - 2 JF - Journal of natural products JO - J Nat Prod VL - 69 IS - 12 N2 - Three new delta-elemanolide-type sesquiterpene lactones, zinagrandinolides A-C (1-3), and the known delta-elemanolide 4 have been isolated by a bioassay-guided fractionation of a cytotoxic hexane extract of the aerial parts of Zinnia grandiflora. The structures of 1-3 were determined on the basis of high-resolution mass and NMR data. All compounds exhibited strong cytotoxicity against the cancer cell lines NCI-H460, MCF-7, SF-268, and MIA Pa Ca-2 and the normal human fibroblast cell type WI-38, but none showed significant selectivity. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/17190470/Zinagrandinolides_A_C_cytotoxic_delta_elemanolide_type_sesquiterpene_lactones_from_Zinnia_grandiflora_ DB - PRIME DP - Unbound Medicine ER -