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Inhibitory effect of MY-1250 on histamine release from rat peritoneal mast cells and guinea pig lung fragments: the elucidation of the mechanism.
Immunopharmacol Immunotoxicol. 1991; 13(3):341-56.II

Abstract

When the effect of MY-1250 (5,6-dihydro-7,8-dimethyl-4,5-dioxo-4 H-pyrano [3,2-c] quinoline-2-carboxylic acid) on histamine release from rat peritoneal mast cells induced by compound 48/80 was studied, MY-1250 caused a significant inhibition of histamine release at concentrations higher than 3 microM. Furthermore, the compound inhibited not only 45C a uptake into the mast cells but also Ca2+ release from the intracellular Ca store at a concentration of 10 microM in both cases. By contrast, MY-1250 did not affect either histamine release from permeabilized mast cells induced by TPA, IP3 and GTP gamma S or Ca2+ release from the endoplasmic reticulum induced by IP3. In the chopped lung preparations, MY-1250 at doses of 10 and 100 microM caused a significant inhibition in histamine release from the pieces of actively sensitized guinea pigs exposed to antigen and simultaneously prevented a decrease in intracellular cAMP contents taking place in association with antigen-antibody reaction. No significant changes were effected by MY-1250 in alpha-chymotrypsin activity and phospholipase A2 activity. Also, no antagonistic effects on LTD4 and PAF were observed.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1719061

Citation

Kamei, C, et al. "Inhibitory Effect of MY-1250 On Histamine Release From Rat Peritoneal Mast Cells and Guinea Pig Lung Fragments: the Elucidation of the Mechanism." Immunopharmacology and Immunotoxicology, vol. 13, no. 3, 1991, pp. 341-56.
Kamei C, Mio M, Izushi K, et al. Inhibitory effect of MY-1250 on histamine release from rat peritoneal mast cells and guinea pig lung fragments: the elucidation of the mechanism. Immunopharmacol Immunotoxicol. 1991;13(3):341-56.
Kamei, C., Mio, M., Izushi, K., Yoshii, N., Fujisawa, K., & Tasaka, K. (1991). Inhibitory effect of MY-1250 on histamine release from rat peritoneal mast cells and guinea pig lung fragments: the elucidation of the mechanism. Immunopharmacology and Immunotoxicology, 13(3), 341-56.
Kamei C, et al. Inhibitory Effect of MY-1250 On Histamine Release From Rat Peritoneal Mast Cells and Guinea Pig Lung Fragments: the Elucidation of the Mechanism. Immunopharmacol Immunotoxicol. 1991;13(3):341-56. PubMed PMID: 1719061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effect of MY-1250 on histamine release from rat peritoneal mast cells and guinea pig lung fragments: the elucidation of the mechanism. AU - Kamei,C, AU - Mio,M, AU - Izushi,K, AU - Yoshii,N, AU - Fujisawa,K, AU - Tasaka,K, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 341 EP - 56 JF - Immunopharmacology and immunotoxicology JO - Immunopharmacol Immunotoxicol VL - 13 IS - 3 N2 - When the effect of MY-1250 (5,6-dihydro-7,8-dimethyl-4,5-dioxo-4 H-pyrano [3,2-c] quinoline-2-carboxylic acid) on histamine release from rat peritoneal mast cells induced by compound 48/80 was studied, MY-1250 caused a significant inhibition of histamine release at concentrations higher than 3 microM. Furthermore, the compound inhibited not only 45C a uptake into the mast cells but also Ca2+ release from the intracellular Ca store at a concentration of 10 microM in both cases. By contrast, MY-1250 did not affect either histamine release from permeabilized mast cells induced by TPA, IP3 and GTP gamma S or Ca2+ release from the endoplasmic reticulum induced by IP3. In the chopped lung preparations, MY-1250 at doses of 10 and 100 microM caused a significant inhibition in histamine release from the pieces of actively sensitized guinea pigs exposed to antigen and simultaneously prevented a decrease in intracellular cAMP contents taking place in association with antigen-antibody reaction. No significant changes were effected by MY-1250 in alpha-chymotrypsin activity and phospholipase A2 activity. Also, no antagonistic effects on LTD4 and PAF were observed. SN - 0892-3973 UR - https://www.unboundmedicine.com/medline/citation/1719061/Inhibitory_effect_of_MY_1250_on_histamine_release_from_rat_peritoneal_mast_cells_and_guinea_pig_lung_fragments:_the_elucidation_of_the_mechanism_ L2 - https://www.tandfonline.com/doi/full/10.3109/08923979109019709 DB - PRIME DP - Unbound Medicine ER -