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A genotype of exceptional longevity is associated with preservation of cognitive function.
Neurology 2006; 67(12):2170-5Neur

Abstract

OBJECTIVE

To test whether cholesterol ester transfer protein (CETP) genotype (VV homozygosity for I405V) is associated with preservation of cognitive function in addition to its association with exceptional longevity.

METHODS

We studied Ashkenazi Jews with exceptional longevity (n = 158; age 99.2 +/- 0.3 years) for the associations of CETP VV genotype and lipoprotein phenotype, using the Mini-Mental State Examination (MMSE). To confirm the role of CETP in a younger cohort, we studied subjects from the Einstein Aging Study (EAS) for associations between CETP VV and cognitive impairment.

RESULTS

Subjects with MMSE > 25 were twice as likely to have the CETP VV genotype (29% vs 14%, p = 0.02), and those with the VV genotype were more likely (61% vs 30%, p = 0.02) to have MMSE > 25. Subjects with the VV genotype had lower levels of CETP (1.73 +/- 0.11 vs 2.12 +/- 0.10 mug/mL, p = 0.01), higher high-density lipoprotein (HDL) levels (p = 0.02), and larger lipoprotein particles (p = 0.03). In the EAS cohort, an approximately fivefold increase in the VV genotype (21% vs 4%, p = 0.02), higher HDL levels, and larger lipoprotein particle sizes were associated with less dementia and improved memory.

CONCLUSIONS

Using two independent cohorts, we implicate the longevity CETP gene as a modulator of age-related cognitive function. A specific CETP genotype is associated with lower CETP levels and a favorable lipoprotein profile. It has not been determined whether modulation of this gene prevents age-related decline or AD.

Authors+Show Affiliations

Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. barzilai@aecom.yu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17190939

Citation

Barzilai, N, et al. "A Genotype of Exceptional Longevity Is Associated With Preservation of Cognitive Function." Neurology, vol. 67, no. 12, 2006, pp. 2170-5.
Barzilai N, Atzmon G, Derby CA, et al. A genotype of exceptional longevity is associated with preservation of cognitive function. Neurology. 2006;67(12):2170-5.
Barzilai, N., Atzmon, G., Derby, C. A., Bauman, J. M., & Lipton, R. B. (2006). A genotype of exceptional longevity is associated with preservation of cognitive function. Neurology, 67(12), pp. 2170-5.
Barzilai N, et al. A Genotype of Exceptional Longevity Is Associated With Preservation of Cognitive Function. Neurology. 2006 Dec 26;67(12):2170-5. PubMed PMID: 17190939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A genotype of exceptional longevity is associated with preservation of cognitive function. AU - Barzilai,N, AU - Atzmon,G, AU - Derby,C A, AU - Bauman,J M, AU - Lipton,R B, PY - 2006/12/28/pubmed PY - 2007/1/17/medline PY - 2006/12/28/entrez SP - 2170 EP - 5 JF - Neurology JO - Neurology VL - 67 IS - 12 N2 - OBJECTIVE: To test whether cholesterol ester transfer protein (CETP) genotype (VV homozygosity for I405V) is associated with preservation of cognitive function in addition to its association with exceptional longevity. METHODS: We studied Ashkenazi Jews with exceptional longevity (n = 158; age 99.2 +/- 0.3 years) for the associations of CETP VV genotype and lipoprotein phenotype, using the Mini-Mental State Examination (MMSE). To confirm the role of CETP in a younger cohort, we studied subjects from the Einstein Aging Study (EAS) for associations between CETP VV and cognitive impairment. RESULTS: Subjects with MMSE > 25 were twice as likely to have the CETP VV genotype (29% vs 14%, p = 0.02), and those with the VV genotype were more likely (61% vs 30%, p = 0.02) to have MMSE > 25. Subjects with the VV genotype had lower levels of CETP (1.73 +/- 0.11 vs 2.12 +/- 0.10 mug/mL, p = 0.01), higher high-density lipoprotein (HDL) levels (p = 0.02), and larger lipoprotein particles (p = 0.03). In the EAS cohort, an approximately fivefold increase in the VV genotype (21% vs 4%, p = 0.02), higher HDL levels, and larger lipoprotein particle sizes were associated with less dementia and improved memory. CONCLUSIONS: Using two independent cohorts, we implicate the longevity CETP gene as a modulator of age-related cognitive function. A specific CETP genotype is associated with lower CETP levels and a favorable lipoprotein profile. It has not been determined whether modulation of this gene prevents age-related decline or AD. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/17190939/A_genotype_of_exceptional_longevity_is_associated_with_preservation_of_cognitive_function_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=17190939 DB - PRIME DP - Unbound Medicine ER -