Tags

Type your tag names separated by a space and hit enter

A genotype of exceptional longevity is associated with preservation of cognitive function.

Abstract

OBJECTIVE

To test whether cholesterol ester transfer protein (CETP) genotype (VV homozygosity for I405V) is associated with preservation of cognitive function in addition to its association with exceptional longevity.

METHODS

We studied Ashkenazi Jews with exceptional longevity (n = 158; age 99.2 +/- 0.3 years) for the associations of CETP VV genotype and lipoprotein phenotype, using the Mini-Mental State Examination (MMSE). To confirm the role of CETP in a younger cohort, we studied subjects from the Einstein Aging Study (EAS) for associations between CETP VV and cognitive impairment.

RESULTS

Subjects with MMSE > 25 were twice as likely to have the CETP VV genotype (29% vs 14%, p = 0.02), and those with the VV genotype were more likely (61% vs 30%, p = 0.02) to have MMSE > 25. Subjects with the VV genotype had lower levels of CETP (1.73 +/- 0.11 vs 2.12 +/- 0.10 mug/mL, p = 0.01), higher high-density lipoprotein (HDL) levels (p = 0.02), and larger lipoprotein particles (p = 0.03). In the EAS cohort, an approximately fivefold increase in the VV genotype (21% vs 4%, p = 0.02), higher HDL levels, and larger lipoprotein particle sizes were associated with less dementia and improved memory.

CONCLUSIONS

Using two independent cohorts, we implicate the longevity CETP gene as a modulator of age-related cognitive function. A specific CETP genotype is associated with lower CETP levels and a favorable lipoprotein profile. It has not been determined whether modulation of this gene prevents age-related decline or AD.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. barzilai@aecom.yu.edu

    , , ,

    Source

    Neurology 67:12 2006 Dec 26 pg 2170-5

    MeSH

    Age Distribution
    Age Factors
    Aged, 80 and over
    Cholesterol Ester Transfer Proteins
    Cognition
    Cognition Disorders
    Female
    Genetic Predisposition to Disease
    Genotype
    Humans
    Jews
    Longevity
    Male
    New York
    Polymorphism, Single Nucleotide
    Prevalence
    Risk Assessment
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17190939

    Citation

    Barzilai, N, et al. "A Genotype of Exceptional Longevity Is Associated With Preservation of Cognitive Function." Neurology, vol. 67, no. 12, 2006, pp. 2170-5.
    Barzilai N, Atzmon G, Derby CA, et al. A genotype of exceptional longevity is associated with preservation of cognitive function. Neurology. 2006;67(12):2170-5.
    Barzilai, N., Atzmon, G., Derby, C. A., Bauman, J. M., & Lipton, R. B. (2006). A genotype of exceptional longevity is associated with preservation of cognitive function. Neurology, 67(12), pp. 2170-5.
    Barzilai N, et al. A Genotype of Exceptional Longevity Is Associated With Preservation of Cognitive Function. Neurology. 2006 Dec 26;67(12):2170-5. PubMed PMID: 17190939.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A genotype of exceptional longevity is associated with preservation of cognitive function. AU - Barzilai,N, AU - Atzmon,G, AU - Derby,C A, AU - Bauman,J M, AU - Lipton,R B, PY - 2006/12/28/pubmed PY - 2007/1/17/medline PY - 2006/12/28/entrez SP - 2170 EP - 5 JF - Neurology JO - Neurology VL - 67 IS - 12 N2 - OBJECTIVE: To test whether cholesterol ester transfer protein (CETP) genotype (VV homozygosity for I405V) is associated with preservation of cognitive function in addition to its association with exceptional longevity. METHODS: We studied Ashkenazi Jews with exceptional longevity (n = 158; age 99.2 +/- 0.3 years) for the associations of CETP VV genotype and lipoprotein phenotype, using the Mini-Mental State Examination (MMSE). To confirm the role of CETP in a younger cohort, we studied subjects from the Einstein Aging Study (EAS) for associations between CETP VV and cognitive impairment. RESULTS: Subjects with MMSE > 25 were twice as likely to have the CETP VV genotype (29% vs 14%, p = 0.02), and those with the VV genotype were more likely (61% vs 30%, p = 0.02) to have MMSE > 25. Subjects with the VV genotype had lower levels of CETP (1.73 +/- 0.11 vs 2.12 +/- 0.10 mug/mL, p = 0.01), higher high-density lipoprotein (HDL) levels (p = 0.02), and larger lipoprotein particles (p = 0.03). In the EAS cohort, an approximately fivefold increase in the VV genotype (21% vs 4%, p = 0.02), higher HDL levels, and larger lipoprotein particle sizes were associated with less dementia and improved memory. CONCLUSIONS: Using two independent cohorts, we implicate the longevity CETP gene as a modulator of age-related cognitive function. A specific CETP genotype is associated with lower CETP levels and a favorable lipoprotein profile. It has not been determined whether modulation of this gene prevents age-related decline or AD. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/17190939/A_genotype_of_exceptional_longevity_is_associated_with_preservation_of_cognitive_function_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=17190939 DB - PRIME DP - Unbound Medicine ER -