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The effect of borderline diabetes on the risk of dementia and Alzheimer's disease.

Abstract

To verify the hypothesis that borderline diabetes may increase the risk of dementia and Alzheimer's disease, a community-based cohort of 1,173 dementia- and diabetes-free individuals aged >or=75 years was longitudinally examined three times to detect patients with dementia and Alzheimer's disease (Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition criteria). Borderline diabetes was defined as a random plasma glucose level of 7.8-11.0 mmol/l. Data were analyzed using Cox proportional hazards models. During the 9-year follow-up, 397 subjects developed dementia, including 307 Alzheimer's cases. At baseline, 47 subjects were identified with borderline diabetes. Borderline diabetes was associated with adjusted hazard ratios (95% CIs) of 1.67 (1.04-2.67) for dementia and 1.77 (1.06-2.97) for Alzheimer's disease; the significant associations were present after additional adjustment for future development of diabetes. Stratified analysis suggested a significant association between borderline diabetes and Alzheimer's disease only among noncarriers of APOE epsilon4 allele. There was an interaction between borderline diabetes and severe systolic hypertension on the risk of Alzheimer's disease (P = 0.04). We conclude that borderline diabetes is associated with increased risks of dementia and Alzheimer's disease; the risk effect is independent of the future development of diabetes. Borderline diabetes may interact with severe systolic hypertension to multiply the risk of Alzheimer's disease.

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  • Authors+Show Affiliations

    ,

    Aging Research Center, Karolinska Institutet, Stockholm, Sweden. weili.xu@ki.se

    , ,

    Source

    Diabetes 56:1 2007 Jan pg 211-6

    MeSH

    Aged, 80 and over
    Alzheimer Disease
    Apolipoprotein E4
    Blood Pressure
    Body Mass Index
    Dementia
    Diabetes Complications
    Diabetes Mellitus
    Female
    Humans
    Incidence
    Male
    Proportional Hazards Models
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17192484

    Citation

    Xu, Weili, et al. "The Effect of Borderline Diabetes On the Risk of Dementia and Alzheimer's Disease." Diabetes, vol. 56, no. 1, 2007, pp. 211-6.
    Xu W, Qiu C, Winblad B, et al. The effect of borderline diabetes on the risk of dementia and Alzheimer's disease. Diabetes. 2007;56(1):211-6.
    Xu, W., Qiu, C., Winblad, B., & Fratiglioni, L. (2007). The effect of borderline diabetes on the risk of dementia and Alzheimer's disease. Diabetes, 56(1), pp. 211-6.
    Xu W, et al. The Effect of Borderline Diabetes On the Risk of Dementia and Alzheimer's Disease. Diabetes. 2007;56(1):211-6. PubMed PMID: 17192484.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The effect of borderline diabetes on the risk of dementia and Alzheimer's disease. AU - Xu,Weili, AU - Qiu,Chengxuan, AU - Winblad,Bengt, AU - Fratiglioni,Laura, PY - 2006/12/29/pubmed PY - 2007/3/27/medline PY - 2006/12/29/entrez SP - 211 EP - 6 JF - Diabetes JO - Diabetes VL - 56 IS - 1 N2 - To verify the hypothesis that borderline diabetes may increase the risk of dementia and Alzheimer's disease, a community-based cohort of 1,173 dementia- and diabetes-free individuals aged >or=75 years was longitudinally examined three times to detect patients with dementia and Alzheimer's disease (Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition criteria). Borderline diabetes was defined as a random plasma glucose level of 7.8-11.0 mmol/l. Data were analyzed using Cox proportional hazards models. During the 9-year follow-up, 397 subjects developed dementia, including 307 Alzheimer's cases. At baseline, 47 subjects were identified with borderline diabetes. Borderline diabetes was associated with adjusted hazard ratios (95% CIs) of 1.67 (1.04-2.67) for dementia and 1.77 (1.06-2.97) for Alzheimer's disease; the significant associations were present after additional adjustment for future development of diabetes. Stratified analysis suggested a significant association between borderline diabetes and Alzheimer's disease only among noncarriers of APOE epsilon4 allele. There was an interaction between borderline diabetes and severe systolic hypertension on the risk of Alzheimer's disease (P = 0.04). We conclude that borderline diabetes is associated with increased risks of dementia and Alzheimer's disease; the risk effect is independent of the future development of diabetes. Borderline diabetes may interact with severe systolic hypertension to multiply the risk of Alzheimer's disease. SN - 0012-1797 UR - https://www.unboundmedicine.com/medline/citation/17192484/The_effect_of_borderline_diabetes_on_the_risk_of_dementia_and_Alzheimer's_disease_ L2 - http://diabetes.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=17192484 DB - PRIME DP - Unbound Medicine ER -