Tags

Type your tag names separated by a space and hit enter

Phytochemical evaluation of selected antioxidant-containing medicinal plants for use in the preparation of a herbal formula--a preliminary study.
Chem Biodivers. 2005 Jul; 2(7):917-22.CB

Abstract

Oxidative damage is implicated in the pathogenesis of a number of diseases. Scientific research shows positive links between accumulated free-radical damage and age-related diseases such as atherosclerosis, Alzheimer, and osteoarthritis. There are reports that plant-derived phenolic compounds such as flavonoids have antioxidant properties capable of reducing the risk of developing these diseases. This work aims to evaluate the antioxidant activity of selected medicinal plants traditionally used by herbalists, in particular for the treatment of arthritis, with a view to developing a formula for treating age and age-related diseases. Thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC) analyses of each plant confirmed the presence of a number of flavonoids reported in the literature, as well as unidentified compounds. The antioxidant activities of these plants were determined by DPPH (= '1,1-diphenyl-2-picryl-hydrazyl') radical scavenging, and by inhibition of linoleic acid peroxidation. All the crude plant extracts showed marked antioxidant activities in both assays. The extracts' inhibitory effects on linoleic acid peroxidation was concentration-dependent, with the highest activity shown at 0.1% (w/v). These results suggest that the phenolic compounds, particularly the flavonoids, may, in part, be responsible for the antioxidant activity of traditional plant extracts.

Authors+Show Affiliations

Department of Herbal Medicine, Human and Exercise Science Academic Group, School of Health, Queensway, Enfield, Middlesex, EN3 4SA, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17193182

Citation

Pendry, Barbara, et al. "Phytochemical Evaluation of Selected Antioxidant-containing Medicinal Plants for Use in the Preparation of a Herbal Formula--a Preliminary Study." Chemistry & Biodiversity, vol. 2, no. 7, 2005, pp. 917-22.
Pendry B, Busia K, Bell CM. Phytochemical evaluation of selected antioxidant-containing medicinal plants for use in the preparation of a herbal formula--a preliminary study. Chem Biodivers. 2005;2(7):917-22.
Pendry, B., Busia, K., & Bell, C. M. (2005). Phytochemical evaluation of selected antioxidant-containing medicinal plants for use in the preparation of a herbal formula--a preliminary study. Chemistry & Biodiversity, 2(7), 917-22.
Pendry B, Busia K, Bell CM. Phytochemical Evaluation of Selected Antioxidant-containing Medicinal Plants for Use in the Preparation of a Herbal Formula--a Preliminary Study. Chem Biodivers. 2005;2(7):917-22. PubMed PMID: 17193182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytochemical evaluation of selected antioxidant-containing medicinal plants for use in the preparation of a herbal formula--a preliminary study. AU - Pendry,Barbara, AU - Busia,Kofi, AU - Bell,Celia M, PY - 2006/12/29/pubmed PY - 2007/2/9/medline PY - 2006/12/29/entrez SP - 917 EP - 22 JF - Chemistry & biodiversity JO - Chem Biodivers VL - 2 IS - 7 N2 - Oxidative damage is implicated in the pathogenesis of a number of diseases. Scientific research shows positive links between accumulated free-radical damage and age-related diseases such as atherosclerosis, Alzheimer, and osteoarthritis. There are reports that plant-derived phenolic compounds such as flavonoids have antioxidant properties capable of reducing the risk of developing these diseases. This work aims to evaluate the antioxidant activity of selected medicinal plants traditionally used by herbalists, in particular for the treatment of arthritis, with a view to developing a formula for treating age and age-related diseases. Thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC) analyses of each plant confirmed the presence of a number of flavonoids reported in the literature, as well as unidentified compounds. The antioxidant activities of these plants were determined by DPPH (= '1,1-diphenyl-2-picryl-hydrazyl') radical scavenging, and by inhibition of linoleic acid peroxidation. All the crude plant extracts showed marked antioxidant activities in both assays. The extracts' inhibitory effects on linoleic acid peroxidation was concentration-dependent, with the highest activity shown at 0.1% (w/v). These results suggest that the phenolic compounds, particularly the flavonoids, may, in part, be responsible for the antioxidant activity of traditional plant extracts. SN - 1612-1880 UR - https://www.unboundmedicine.com/medline/citation/17193182/Phytochemical_evaluation_of_selected_antioxidant_containing_medicinal_plants_for_use_in_the_preparation_of_a_herbal_formula__a_preliminary_study_ L2 - https://doi.org/10.1002/cbdv.200590068 DB - PRIME DP - Unbound Medicine ER -