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Synthesis of indenes by the transition metal-mediated carboannulation of alkynes.
J Org Chem. 2007 Jan 05; 72(1):251-62.JO

Abstract

The synthesis of highly substituted indenes has been achieved by three different transition metal-mediated methods. The first method involves the palladium-catalyzed carboannulation of internal alkynes. The second method utilizes a two-step approach, which involves first the palladium/copper-catalyzed cross-coupling of terminal alkynes with appropriately functionalized aryl halides, followed by copper-catalyzed intramolecular cyclization. The third method involves intermolecular palladium-catalyzed arylation of the arylalkynes formed in the first step of the second method.

Authors+Show Affiliations

Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17194107

Citation

Zhang, Daohua, et al. "Synthesis of Indenes By the Transition Metal-mediated Carboannulation of Alkynes." The Journal of Organic Chemistry, vol. 72, no. 1, 2007, pp. 251-62.
Zhang D, Liu Z, Yum EK, et al. Synthesis of indenes by the transition metal-mediated carboannulation of alkynes. J Org Chem. 2007;72(1):251-62.
Zhang, D., Liu, Z., Yum, E. K., & Larock, R. C. (2007). Synthesis of indenes by the transition metal-mediated carboannulation of alkynes. The Journal of Organic Chemistry, 72(1), 251-62.
Zhang D, et al. Synthesis of Indenes By the Transition Metal-mediated Carboannulation of Alkynes. J Org Chem. 2007 Jan 5;72(1):251-62. PubMed PMID: 17194107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis of indenes by the transition metal-mediated carboannulation of alkynes. AU - Zhang,Daohua, AU - Liu,Zhijian, AU - Yum,Eul K, AU - Larock,Richard C, PY - 2006/12/30/pubmed PY - 2007/2/14/medline PY - 2006/12/30/entrez SP - 251 EP - 62 JF - The Journal of organic chemistry JO - J Org Chem VL - 72 IS - 1 N2 - The synthesis of highly substituted indenes has been achieved by three different transition metal-mediated methods. The first method involves the palladium-catalyzed carboannulation of internal alkynes. The second method utilizes a two-step approach, which involves first the palladium/copper-catalyzed cross-coupling of terminal alkynes with appropriately functionalized aryl halides, followed by copper-catalyzed intramolecular cyclization. The third method involves intermolecular palladium-catalyzed arylation of the arylalkynes formed in the first step of the second method. SN - 0022-3263 UR - https://www.unboundmedicine.com/medline/citation/17194107/Synthesis_of_indenes_by_the_transition_metal_mediated_carboannulation_of_alkynes_ L2 - https://doi.org/10.1021/jo0620563 DB - PRIME DP - Unbound Medicine ER -